Prolonged, Recurrent, and Periodic Fever Syndromes

Long, Sarah S.; Edwards, Kathryn M.

doi:10.1016/b978-0-7020-3468-8.50023-7

Cited by 7 publications

(6 citation statements)

References 148 publications

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“…It was a prospective observational study and evaluated the clinical profile and etiological spectrum of fever beyond 2 weeks duration in children aged 2 months to 12 years without an obvious diagnosis at presentation after a detailed history and clinical examination, which fulfils the definition of FUO as defined by Long and Edwards. 1 Children with a documented recurrent fever and periodic fever syndromes were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

“…Fever beyond 2 weeks or for the practical purposes, FUO still remains the daunting challenge for any pediatrician. 1 The term fever of unknown origin came into light after the publication by Petersdorf and Beeson among the adult population and defined it as temperature >38.3 o C on several occasions and lasting longer than 3 weeks with a diagnosis which remain uncertain after 1 week of investigations in the hospital. 2 Since then various studies had been conducted across the globe among different age groups to evaluate etiologies of FUO, which again revealed variations based on several epidemiological factors.…”

Section: Introductionmentioning

confidence: 99%

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Clinical profile and etiological spectrum of fever of unknown origin in children aged 2 months to 12 years

Govindarajulu

Kalyanasundaram

Pyarejan

et al. 2017

Int J Contemp Pediatr

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Background: Fever of unknown origin is one of the leading etiologies for morbidity and mortality among children worldwide and their spectrum keeps changing constantly from time to time. The objective of this study was to study the clinical profile and etiological spectrum of fever beyond 2 weeks duration in children aged 2 months to 12 years admitted in a tertiary care hospital. Methods: A prospective observational study, done in tertiary care centre over six month period (May 2016 to October 2016). Children aged 2 months to 12 years presenting with fever beyond 2 weeks duration fulfilling the inclusion criteria were included in the study and evaluated further. Initial investigations include complete blood count including peripheral smear for MP/malignancy, urine routine, chest X-ray, mantoux, CRP, blood and urine cultures were done followed by specific serology tests and further relevant investigations. The etiological outcomes were mainly analysed. Results: The etiological outcomes of the study were classified into 5 groups as infections, malignancies, connective tissue disorder, miscellaneous and undiagnosed. Among the study population, infection emerged as the major etiological outcome constituting 69.1% followed by malignancies (16.7%), connective tissue disorder (5%), miscellaneous (5.8%) and undiagnosed (3.4%). Conclusions: Infections, especially enteric fever still remains the leading etiology of fever beyond 2 weeks duration or FUO in children aged 2months to 12 years. Irrational usage of antibiotics has been highlighted in general practice which needs to be amended by periodic discussions and epidemiological surveys to prevent the emergence of drug resistance.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical profile and etiological spectrum of fever of unknown origin in children aged 2 months to 12 years

Govindarajulu

Kalyanasundaram

Pyarejan

et al. 2017

Int J Contemp Pediatr

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“…These authors assigned their case a Naranjo score of 3 (‘possible’) [ 2 ]. Drug-induced fever starts within a few days of beginning dexmedetomidine and dissipates entirely in a 3-5 half-life of elimination [ 8 ]. It has a distribution half-life of six minutes and an elimination half-life of two hours [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine-Induced Fever in a 66-Year-Old Male With Pneumonia and Pleural Effusion

Imtiaz¹,

Prasad²,

Marin³

et al. 2022

Cureus

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Drug-induced fever is a significant adverse effect as many commonly used medications can cause this. The incidence of drug fever is even higher in critical care settings because multiple medications are being administered simultaneously. This poses a serious problem in critical care settings as any new fever in these settings also implies any new infection or worsening of preexisting conditions. This may lead to a detailed investigation for the cause of fever, which can be time-consuming, invasive, costly, and may also increase the duration of stay along with an associated increase in morbidity and mortality. We want to highlight an adverse drug event through a documented case of Dexmedetomidine-induced fever in a critical care patient with multiple pathologies.

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“…Fever of unknown origin continues to be a complicated problem since its diagnosis depends on geographical regions, socioeconomic conditions and the experience of the clinicians evaluating the patient. Another reason further complicating the diagnosis is the lack of a generally accepted diagnostic algorithm in spite of the developments in the diagnostic methods 3,4,6 . In developing and developed countries, the most common cause of the fever of unknown origin is infectious diseases.…”

Section: Discussionmentioning

confidence: 99%

Nedeni bilinmeyen ateş: 30 çocuk hastanın değerlendirilmesi

Gündeşli̇oğlu

Kocabaş

Alhan³

et al. 2019

Cukurova Medical Journal

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The aim of this retrospective study is to evaluate the etiology clinical and laboratory features of fever of unknown origin (FUO) diagnosed in 30 pediatric patients. Materials and Methods: The clinical data including the etiology, diagnostic approaches and clinical characteristics were retrospectively analysed in 30 pediatric patients with FUO who presented to our clinic in oneyear period. Results: The median age of the patients was 63 (6-192) months. Among the patients, 12 were male (40%), while 18 were female (60%). The median duration of the fever was 22.5 (3-60) days during hospital admission. The most common physical findings were hepatomegaly and splenomegaly, which were observed in 53. 3 and 40 patients, respectively. The cause of the FUO was detected to be infection in 14 patients (46.6%), connective tissuevascular diseases in 8 patients (26.7%), malignancies in 5 patients (16.7%), and miscellaneous diseases in 1 patient (3.3%). In two patients (6.6%) the etiology could not be identified. Leishmaniasis, tuberculosis and Brucellosis were the most commonly identified infections, whereas juvenile rheumatoid arthritis and acute lymphoblastic leukemia were the most common non-infectious causes. Conclusion: The most common cause of FUO in our study was infection diseases. Connective-vascular tissue diseases and malignancies are also important causes of FUO. In our opinion, detailed patient history, carefully physical examination and close clinical follow-up may reduce the number of the invasive procedures and noninvasive tests.

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Prolonged, Recurrent, and Periodic Fever Syndromes

Cited by 7 publications

References 148 publications

Clinical profile and etiological spectrum of fever of unknown origin in children aged 2 months to 12 years

Clinical profile and etiological spectrum of fever of unknown origin in children aged 2 months to 12 years

Dexmedetomidine-Induced Fever in a 66-Year-Old Male With Pneumonia and Pleural Effusion

Nedeni bilinmeyen ateş: 30 çocuk hastanın değerlendirilmesi

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