Prolonged release of ciprofloxacin hydrochloride from chitosan/gelatin/poly (vinyl alcohol) composite films

Lian, Ruizhe; Cao, Jinxing; Rogachev, A.V.

doi:10.1016/j.mtcomm.2021.102219

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…This result was expected since CS, Gel, and PVA are reported as nontoxic compounds. Lian et al who synthesized films with CS, Gel, and PVA found no sign of toxic impacts on the cells . Similar results were also reported to by Shamloo et al who prepared the CS–Gel–PVA hydrogel for wound healing applications …”

Section: Resultssupporting

confidence: 80%

“…Lian et al who synthesized films with CS, Gel, and PVA found no sign of toxic impacts on the cells. 77 Similar results were also reported to by Shamloo et al who prepared the CS−Gel−PVA hydrogel for wound healing applications. 78 Additionally, it was found that PCG loaded with LEV did not affect the cytotoxicity of the scaffold.…”

Section: Structural Characterizationsupporting

confidence: 85%

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3D-Printed Chitosan-Based Hydrogels Loaded with Levofloxacin for Tissue Engineering Applications

Koumentakou,

Noordam,

Michopoulou

et al. 2023

Biomacromolecules

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Section: Resultssupporting

confidence: 80%

Section: Structural Characterizationsupporting

confidence: 85%

3D-Printed Chitosan-Based Hydrogels Loaded with Levofloxacin for Tissue Engineering Applications

Koumentakou,

Noordam,

Michopoulou

et al. 2023

Biomacromolecules

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“…Similarly, the ZOI diameters of F3D and F4D were similar (p > 0.05). The antibacterial activity of CPH-loaded PVA films synthesized by Lian et al (2021) [77] and David et al (2021) [78] showed results similar to the obtained results.…”

Section: Antimicrobial Studysupporting

confidence: 85%

Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Rawooth

Habibullah²,

Qureshi

et al. 2022

Polymers

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The current study aims to evaluate the effect of tamarind gum (TG) on the optical, mechanical, and drug release potential of poly(vinyl alcohol) (PVA)-based films. This involves preparing PVA-TG composite films with different concentrations of TG through a simple solvent casting method. The addition of TG has enhanced the phase separation and aggregation of PVA within the films, and it becomes greater with the increase in TG concentration. Brightfield and polarized light micrographs have revealed that aggregation is favored by forming crystalline domains at the PVA-TG interface. The interconnected network of PVA-TG aggregates influenced the swelling and drying properties of the films. Using Peleg’s analysis, the mechanical behavior of films was determined by their stress relaxation profiles. The addition of TG has made no significant changes to the firmness and viscoelastic properties of films. However, long-durational relaxation times indicated that the interconnected network might break down in films with higher TG concentration, suggesting their brittleness. The controlled release of ciprofloxacin in HCl solution (0.5% (w/v)) appears to decrease with the increase in TG concentration. In fact, TG has inversely affected the impedance and altered the ionic conductivity within the films. This seems to have directly influenced the drug release from the films as the mechanism was found to be non-Fickian diffusion (based on Korsmeyer–Peepas and Peppas–Sahlin kinetic models). The antimicrobial study using Escherichia coli was carried out to evaluate the activity of the drug-loaded films. The study proves that TG can modulate the properties of PVA films and has the potential to fine-tune the controlled release of drugs from composite films.

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“…For example, a mixture of PVA with basil leaf extract helps increase the antioxidant and antimicrobial properties of the film [45]. Some other materials that have been studied to improve the antibacterial properties of the film include tomato pulp [46], zinc oxide nanoparticles [47], bacterial cellulose nanowhiskers [48] and ciprofloxacin hydrochloride [49]. These show that gelatin and PVA can be mixed or incorporated together with many other materials to improve not only the antioxidant properties but also antimicrobial properties.…”

Section: Biomaterials For the Filmmentioning

confidence: 99%

Gelatin-Polyvinyl Alcohol Film for Tissue Engineering: A Concise Review

Zulkiflee

2021

Biomedicines

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The field of biomaterials has been steadily expanding as a large number of pharmaceutical and manufacturing companies invest in research in order to commercialize biomaterial products. Various three-dimensional biomaterials have been explored including film, hydrogel, sponge, microspheres etc., depending on different applications. Thus, gelatin and polyvinyl alcohol (PVA) are widely used as a natural- and synthetic-based biomaterial, respectively, for tissue engineering and clinical settings. The combination of these materials has proven its synergistic effects in wound-healing applications. Therefore, this review aims to highlight the hybrid gelatin and PVA thin film development and evaluate its potential characteristics for tissue engineering applications from existing published evidence (within year 2010–2020). The primary key factor for polymers mixing technology might improve the quality and the efficacy of the intended polymers. This review provides a concise overview of the current knowledge for hybrid gelatin and PVA with the method of fabricating and mixing technology into thin films. Additionally, the findings guided to an optimal fabrication method and scrutinised characterisation parameters of fabricated gelatin-PVA thin film. In conclusion, hybrid gelatin-PVA thin film has higher potential as a treatment for various biomedical and clinical applications.

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Prolonged release of ciprofloxacin hydrochloride from chitosan/gelatin/poly (vinyl alcohol) composite films

Cited by 7 publications

References 38 publications

3D-Printed Chitosan-Based Hydrogels Loaded with Levofloxacin for Tissue Engineering Applications

3D-Printed Chitosan-Based Hydrogels Loaded with Levofloxacin for Tissue Engineering Applications

Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Gelatin-Polyvinyl Alcohol Film for Tissue Engineering: A Concise Review

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