Prolonged release of metformin by SiO2 nanoparticles pellets for type II diabetes control

Patiño‐Herrera, Rosalba; Louvier-Hernández, José Francisco; Escamilla‐Silva, Eleazar M.; Chaumel, Julie; Palestino, Gabriela; Pérez, Elı́as

doi:10.1016/j.ejps.2019.02.003

Cited by 40 publications

(23 citation statements)

References 29 publications

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“…Ibuprofen non‐steroidal anti‐inflammatory drugs were loaded into the pores of two mesoporous silica MCM‐41, and it was found that ibuprofen could be released slowly in mesoporous silica 7 . Silica can extend the release of metformin and be used to control Type 2 diabetes 8 . Therefore, in the field of biomedicine, the application of mesoporous silica has rapidly become the focus of medical materials research.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Zhao

Zhang

et al. 2021

Environmental Toxicology

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Mesoporous silica is widely used because of its unique and excellent properties, especially it can be used as a drug carrier and gene carrier in the biomedical field. After the mesoporous silica is put into clinical use, it is more likely to be exposed in human body. Therefore, the effect of mesoporous silica on human body cannot be ignored. The injury of vascular endothelial cells is a prerequisite for the occurrence of many cardiovascular diseases. As a drug and gene carrier, mesoporous silica increases its contact with vascular endothelial cells, so its toxic effect on cardiovascular system cannot be ignored. In this study, amino (NH2) and carboxyl (COOH) were modified on mesoporous silica SBA‐15 by post‐grafting. The results showed that it still maintained the one‐dimensional hexagonal mesoporous structure of SBA‐15 and had typical mesoporous structure. Then human umbilical vein endothelial cells (HUVECs) were infected with SBA‐15, NH2‐SBA‐15, and COOH‐SBA‐15. The results showed that the functionalized mesoporous silica SBA‐15 had cytotoxicity to HUVECs and damaged the cell membrane, but compared with the unmodified mesoporous silica SBA‐15 the cytotoxicity of functionalized mesoporous silica SBA‐15 was lower and the toxicity of carboxyl modified group was the lowest. By comparing the cell inhibition rate and the expression level of lactate dehydrogenate and reactive oxygen species induced by the three materials, oxidative damage and cell membrane damage may be two mechanisms of cytotoxicity. Mesoporous silica SBA‐15 has an effect on cardiovascular system by inducing the high expression of nitric oxide, intercellular adhesive molecule‐1 and vascular cell adhesive molecule‐1 in HUVECs. In summary, our results show that mesoporous silica is toxic to vascular endothelial cells.

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Zhao

Zhang

et al. 2021

Environmental Toxicology

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“…As a result, low dose of MET-loaded alginate NPs (46.8 mg/kg) produced comparable hypoglycaemic effects with high dose of free MET (150 mg/kg) (Kumar et al 2017). The advantages of METloaded nano-DDS for oral drug delivery should be attributed to the sustained drug release and enhanced gastrointestinal permeability, resulting in significant decrease dosage of MET (Cui et al 2018;Patiño-Herrera et al 2019).…”

Section: Met-encapsulated Nano-dds For Oral Deliverymentioning

confidence: 99%

Emerging nanoparticulate drug delivery systems of metformin

Chen

Shan

Luo

et al. 2020

J. Pharm. Investig.

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Background Driving the conventional drug in new applications has emerged as a research hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of type II diabetes. It has also been found to be a versatile molecule with wide biological functions, such as losing weight. anti-aging and anticancer activity. Rational design of nanoparticulate drug delivery systems (nano-DDS) could significantly improve drug delivery efficiency. Recently, a wide range of nano-DDS has been developed to improve the delivery efficacy of MET or to perform as versatile nanoplatforms for efficient drug delivery. Area covered In this review, we outline the emerging trends in advanced nano-DDS of MET, focusing on nano-DDS of MET for diabetes therapy, nano-DDS of MET for anticancer therapeutics, and nano-DDS of MET for other therapeutic aims. Expert opinion Despite the great progression in nano-DDS of MET, there's still a long way to truly put the conventional drug in new applications. Several important issues should be fully taken into consideration, such the manufacturing cost and economic burdens for patients, the biocompatibility and long-term toxicity of carrier materials, scale-up preparation difficulties, as well as the species gap between human beings and animal models.

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“…The diameter of the mesoporous silica nanoparticles ranges from 2 to 50 nm. Patiño-Herrera., et al [10] formulated metformin by SiO2 nanoparticles pellets for the gradual release of the drug. Metformin Hcl is one of the most widely used drugs for the treatment of diabetes mellitus.…”

Section: Conventional Antidiabetic Drugs In Marketmentioning

confidence: 99%

A Smart Drug Delivery Silica Nanoparticles System for Diabetes Mellitus Disease Treatment

Elaty¹,

Fakhry²

2019

Act Scie Pharma

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Type 2 diabetes makes up approximately 85% of all diabetic cases and it is linked to approximately one-third of all hospitalizations.Diabetes mellitus is a metabolic disorder that can lead to complications such as kidney failure, blindness, ketoacidosis, stroke and heart diseases. Types of diabetes mellitus are Type 1 diabetes mellitus, Type 2 diabetes mellitus and Gestational diabetes mellitus.Drugs used in the treatment of diabetes are insulin, sulphonylureas, biguanides, thiazolidinediones, α-glcosidase inhibitors and dipeptidyl peptidase IV inhibitors. Newer therapies with long-acting biologics such as glucagon-like peptide-1 (GLP-1) analogues have been promising in managing the disease, but they cannot reverse the pathology of the disease. Additionally, their parenteral administration is often associated with high healthcare costs and risk of infections. .Oral delivery of these compounds would significantly improve patient compliance; however, poor enzymatic stability and low permeability across the gastrointestinal tract makes this task challenging. Nanotechnology is the use of nanomaterial's which are smaller than 100 nm either be natural or manmade. Silica nanoparticles possess numerous advantages including optimum biocompatibility and bio distribution. Silica nanoparticles (SNPs) are emerging functional inorganic nanomaterials which offer an alternative to traditional carriers for oral delivery of peptides and drugs ; Modification of SNPs with appropriate functional groups improves control over the loading/release of payload for oral delivery. Metformin was loaded by SiO2 nanoparticles to release the drug gradually, glimepiride was loaded on both MCM-41 and Hollow mesoporous silica nanoparticles for the improvement of solubility and insulin was loaded on the mesoporous silica nano particles to control its release. MSNs like MCM-41, MCM-48, SBA-1, SBA-3, SBA-15, SBA-16 are tested to drugs delivery for different diseases e.g. inflammation, cancer, diabetes, neurological disorders and even as a carriers in gene therapy or biosensor in diagnosis. The reasons of their popularity are that these materials have a several advantages, such as unique ordered structure of high specific area and pore volume and consequently high sorption capacity. Moreover production of these materials is relatively simple, inexpensive and easy controllable. Finally, they are nontoxic and biocompatible which are the key requirements.Szablewski [1] cited that diabetes mellitus is a metabolic disorder that lasts for the lifetime of a person and can lead to complications such as kidney failure, blindness, ketoacidosis, stroke and heart disease. Symptoms of diabetes mellitus include polydipsia, Diabetes mellituspolyuria, polyphagia, blurred vision, fatigue and poor wound healing. Type 1 diabetes mellitus is an organ specific autoimmune disease that is attributed to the specific adaptive immunity against the antigens of the β cells. Despite the fact that type 1 diabetes mellitus occur at any age, it is diagnosed in most of the cases befor...

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Prolonged release of metformin by SiO2 nanoparticles pellets for type II diabetes control

Cited by 40 publications

References 29 publications

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Emerging nanoparticulate drug delivery systems of metformin

A Smart Drug Delivery Silica Nanoparticles System for Diabetes Mellitus Disease Treatment

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