Prolonged Remission of Upper Urinary Tract Urothelial Carcinoma With Prominent Choriocarcinomatous Differentiation: A Case Report

Msaouel, Pavlos; Zhang, Miao; Tu, Shi Ming

doi:10.1016/j.clgc.2016.08.025

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Urothelial carcinoma with trophoblastic differentiation (UCTD) is a rare and specific subtype of high-grade infiltrating urothelial carcinoma (HGUC) with syncytiotrophoblastic cells and positive immunohistochemical (IHC) staining for β-hCG. However, to our knowledge, most reported cases are from the urinary bladder, with only seven original reports concerning this specific subtype of renal pelvis UC reported in English literature (1)(2)(3)(4)(5)(6)(7). Herein, we report another case of a 55-year-old man with UCTD involving the renal pelvis.…”

Section: Introductionmentioning

confidence: 86%

Case report: Urothelial carcinoma of the renal pelvis with trophoblastic differentiation: A rare case report and review of literature

Wang¹,

Wang²,

Zhang³

et al. 2023

Pathol. Oncol. Res.

View full text Add to dashboard Cite

We report a rare case of urothelial carcinoma (UC) of the renal pelvis with trophoblastic differentiation that occurred in a 55-year-old male patient. The patient presented with gross hematuria and paroxysmal lumbago pain 5 months ago. The enhanced computed tomography (CT) scan demonstrated a large space occupying lesion in the left kidney and multiple retroperitoneal lymph node enlargements. Histologically, high-grade infiltrating urothelial carcinoma (HGUC) contained giant cells which were positive for beta-human chorionic gonadotropin (β-hCG). Three weeks after resection, positron emission tomography and computed tomography (PET-CT) scan showed multiple nodules of metastasis in the left renal region, extensive systemic muscle, bone, lymph node, liver and bilateral lung metastases. The patient underwent bladder perfusion chemotherapy and gemcitabine combined with cisplatin chemotherapy regimens. This is the eighth documented case of UC of the renal pelvis with trophoblastic differentiation. Due to its rarity and extremely poor prognosis, it is important to clarify the characteristics of the disease and make an accurate and prompt diagnosis.

show abstract

Section: Introductionmentioning

confidence: 86%