Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy

Klein, Amber; He, Xiaoying; Roche, Maria; Mallett, A.; Duska, Linda; Supko, Jeffrey G.; Seiden, Michael V.

doi:10.1016/j.ygyno.2005.08.006

Cited by 20 publications

(14 citation statements)

References 17 publications

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“…In the placebo group, an increase in appetite loss was detected under chemo-and radiation therapy from 41.8% to 70.9 % (Figure 26). This study was conducted in China, but similar results were obtained in the USA at Harvard Medical School [44].…”

Section: Figure 23supporting

confidence: 66%

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Can Plants’ Ability for DNA Repair and Stress Defense be Used against Patients’ Circulating Tumor Cells?

Rohr¹,

Volko²

2015

J. Pharm. Nutr. Sci.

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Introduction: It was suggested that specific plants may reduce cancer's resistance to chemotherapy. Resistance inhibits apoptosis, as well as other fundamental anti-cancer protective mechanisms. Soy bean has been found to reduce cellular stress and repair DNA damage caused by drought or parasites, and can transfer this defense mechanism to other plant species as well. The aim of this study is therefore to conduct a systematic comparison of the effect of soy bean formulation (FSWW08) on gene expression in in vitro human breast cancer cell line, and in in vivo in blood circulating tumor cells (CTC), after oral consumption of FSWW08 by patients suffering from breast-, ovarian-, and prostate cancer. Method: In vitro gene expressions studies were conducted with the human breast cancer cell line BT-474 that was exposed to doxorubicin or FSWW08, either alone or in combination. Ovarian-, prostate-, and breast cancer patients received FSWW08 for 30 days. CTC were extracted from their blood according to an established protocol. Gene expression evaluations were conducted before and after treatment. Results: In vitro, the multi-drug resistance (MDR) protein was reduced by FSWW08, but was increased by doxorubicin. The combination of FSWW08 and doxorubicin, however, showed a protective effect against the increase of MDR in physiologic concentrations, increased, however, also in high experimental concentrations of both agents. The expression of several cancer-related protective genes, such as tumor suppressor factors p21, p38 and p53, was improved by FSWW08 in vitro and in vivo, which helped cell differentiation and new tissue formation. Additionally, the BAX/Bcl2 ratio was improved, in vitro, as well as gene expression of estrogen receptor beta, NF-B, MAP kinase, c-JUN, and matrix metalloproteinase 9, together with an increase of VEGF expression in vivo in CTC. Conclusion: It was demonstrated that FSWW08 improved the gene functions related to DNA repair and stress in human blood CTC and resistance marker, in vitro, when applied in combination with doxorubicin. As such, larger in vitro and in vivo clinical studies that investigate single botanical compounds from other plants, are warranted.

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Section: Figure 23supporting

confidence: 66%

“…All in vitro procedures determining the gene expression determination have been described before [24,39,40,44]…”

Section: B In Vitro Gene Expression Investigationmentioning

confidence: 99%

Can Plants’ Ability for DNA Repair and Stress Defense be Used against Patients’ Circulating Tumor Cells?

Rohr¹,

Volko²

2015

J. Pharm. Nutr. Sci.

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“…Furthermore, an in vivo research concerning the 7,12-dimethylbenz[ a ]anthracene (DMBA)-induced rat ovarian carcinogenesis confirmed the anti-tumor activity of genistein in vitro [70]. In addition, a recent clinical report described that a woman with platinum-refractory ovarian cancer entered into a phase of prolonged disease stabilization after a long-term intake of a soy beverage which contained rich of isoflavones, providing a strong support that phytoestrogens exerted a potential inhibitory effect on the human ovarian cancer [71]. These facts from the in vitro , in vivo and clinical research indicate that phytoestrogen might play a potential role to suppress the invasion, metastasis and growth of ovarian cancers.…”

Section: Discussionmentioning

confidence: 99%

Phytoestrogen Biological Actions on Mammalian Reproductive System and Cancer Growth

Zhao

Mu²

2011

Sci. Pharm.

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Phytoestrogens are a family of diverse polyphenolic compounds derived from nature plant that structurally or functionally mimic circulating estrogen in the mammalian reproductive system. They induce estrogenic and anti-estrogenic effects in the brain-pituitary-gonad axis (a principal endocrine system involving in reproductive regulation) and peripheral reproductive organs. The dichotomy of phytoestrogen-mediated actions elucidates that they play the biological activities via complex mechanisms and belong to various chemical classes. In comparison with their unobvious physiological functions in normal reproductive tissues, there are increasing investigations showing that phytoestrogen induces significant inhibitory effects on the growth of breast and ovarian cancers through different signaling pathways. This review summarized the results of the previous studies regarding principal signaling transductions for mediating the growth of the ovarian and breast cancers. Phytoestrogen potentially modulates the signaling molecules via: (1) blocking the nuclear and membrane estrogen receptors (ER), (2) interfering with the growth factor receptor, (3) inhibiting the G protein-coupled receptor in ER-deficient cells, (4) activating apoptosis and nullifying anti-apoptotic signals.

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“…There is a clinical report, where a prolonged stabilization of platinum resistant ovarian cancer was obtained when consuming fermented soy (146). In the future, plant extracts, such as fermented soy, can help to avoid chemosensitization.…”

Section: Antiproliferative Effects Of Soy Isoflavones Via Nf-kb On CImentioning

confidence: 99%

Cancer protection of soy resembles cancer protection during pregnancy

Rohr¹,

Gocan²,

Bachg³

et al. 2010

Hormone Molecular Biology and Clinical Investigation

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It has been established that carrying a pregnancy to full-term at an early age can protect against contracting cancer by up to 50% in later life. The trophoblast theory of cancer states that trophoblast and cancer tissue are very similar. New findings suggest that the loss of fetal cells during pregnancy resemble those cells responsible for causing metastasis in cancer. Fetal cells and spreading cancer cells are highly proliferative. They are similar to stem cells, exhibiting no or low hormone receptor expression, and require a hormone receptor independent mechanism for control. Control of membrane stability during pregnancy is of vital importance for a successful pregnancy and is mediated by androstenediol and 2-methoxyestradiol. 2-Methoxyestradiol has no hormone receptor affinity and elicits strong anticancer effects particularly against cancer stem cells and fetal cells, for which currently no treatment has yet been established. There is a discussion whether pregnancy reduces cancer stem cells in the breast. Soy isoflavones are structurally similar to both hormones, and elicit strong anticancer effects and antiangiogenesis via inhibition of NF-κB, even in hormone receptor independent breast cancers seen in epidemiologic studies. The trophoblast theory of cancer could help to explain why soy baby nutrition formulas have no effect on baby physiology, other than the nutritional aspect, although soy elicits many effects on the adult immune system. To survive the immune system of the mother, the immune system of the fetus has to be separated; otherwise, the reduction of the immune system in the mother, a necessary feature for the blastocyst to grow, would immediately reduce the immunity for the fetus and endanger its survival. Similar to a fetus, newly born babies show immune insensitive to Th1 and Th2 cytokines, which are necessary and crucial for regulating the immune system of the mother, thus raising the risk of the baby of developing allergies and neurodermatitis. Gene expression studies in vitro as well as in circulating tumor cells from patients consuming a fermented soy product support the antiangiogenic as well as antiproliferative effects of soy.

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Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy

Cited by 20 publications

References 17 publications

Can Plants’ Ability for DNA Repair and Stress Defense be Used against Patients’ Circulating Tumor Cells?

Can Plants’ Ability for DNA Repair and Stress Defense be Used against Patients’ Circulating Tumor Cells?

Phytoestrogen Biological Actions on Mammalian Reproductive System and Cancer Growth

Cancer protection of soy resembles cancer protection during pregnancy

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