Prolonged suppression of tinnitus after peripheral nerve block using bupivacaine and lidocaine

Weinmeister, Kent P.

doi:10.1016/s1098-7339(00)80013-9

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…A notable exception is local anaesthetics: in 1935, Bárány noted that intravenous injection of procaine temporarily alleviated tinnitus in most patients. 60 Lidocaine 61 and bupivacaine 62 also have this eff ect. Subsequent work has shown that the alleviation occurs within the central auditory pathways of the brain, 63 although an additional cochlear eff ect cannot be excluded.…”

Section: Drug Treatmentsmentioning

confidence: 97%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

1,063

911

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Tinnitus is a common medical symptom that can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury, and depression. At presentation, the possibilities of otological disease, anxiety, and depression should be considered. No eff ective drug treatments are available, although much research is underway into mechanisms and possible treatments. Surgical intervention for any otological pathology associated with tinnitus might be eff ective for that condition, but the tinnitus can persist. Available treatments include hearing aids when hearing loss is identifi ed (even mild or unilateral), wide-band sound therapy, and counselling. Cognitive behavioural therapy (CBT) is indicated for some patients, but availability of tinnitus-specifi c CBT in the UK is poor. The evidence base is strongest for a combination of sound therapy and CBT-based counselling, although clinical trials are constrained by the heterogeneity of patients with tinnitus.

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Section: Drug Treatmentsmentioning

confidence: 97%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

1,063

911

View full text Add to dashboard Cite

show abstract

“…Weinmeister [5] published in 2000 regarding Prolonged suppression of tinnitus after peripheral nerve block using bupivacaine and lidocaine. The local anesthetic lidocaine has been shown to suppress tinnitus, albeit very temporarily, when administered intravenously.…”

Section: Relief Of Tinnitus With Bupivacainementioning

confidence: 99%

Intratympanic bupivacaine instillation for tinnitus treatment?

Eldor¹

2013

J Anesthesiol Clin Sci

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Tinnitus is an early diagnostic sign of an inadvertent intravenous injection of bupivacaine epidural test dose. However, Bupivacaine can also relieve tinnitus. For example, a 57-year-old man undergoing facet and sacroiliac infiltration with lidocaine and bupivacaine experienced symptoms of systemic local anesthetic toxicity. He described significant perioral numbness. Shortly after this the patient noted that his long-standing and severe tinnitus was completely gone. Another study of a total of 50 young soldiers hospitalized for high frequency hearing loss and tinnitus following exposure to gun impulse noise was studied in order to ascertain the effects of two kinds of medical treatment. In a 17 subjects gangliosides were associated with subcutaneous infiltration of bupivacaine chlorhydrate (0.5%). An improvement in hearing threshold (= greater than 20 dB at 4-8 kHz) and a consistent relief of tinnitus was respectively found in 66% of the treated subjects.

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“…Subsequently, the effects of lidocaine on tinnitus have been con rmed by double-blind studies (3,4). Recently, Weinmeister (5) reported a case of prolonged suppression of tinnitus after peripheral nerve block using a combination of lidocaine and bupivacaine. Sanchez et al (6) evaluated the response to i.v.…”

Section: Introductionmentioning

confidence: 96%

Effects of Lidocaine on Basilar Membrane Vibration in the Guinea Pig

Maruyama

Kobayashi²,

Sugimoto³

et al. 2001

Acta Oto-Laryngologica

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The effects of lidocaine on basilar membrane (BM) vibration and compound action potential (CAP) were studied in guinea pigs in order to elucidate the site of lidocaine action in the cochlea. BM vibration was measured with a laser Doppler vibrometer through an opening made in the lateral bony wall of the scala tympani at the basal turn. Ten min after local administration of lidocaine (250 microg) into the scala tympani, the velocity of BM vibration and the CAP amplitude decreased significantly at around the characteristic frequency of the stimulus sound (p < 0.05). The maximum decreases were 4 dB in the velocity of the BM vibration and 40 dB in the CAP amplitude. In contrast, such changes were not observed after i.v. injection of lidocaine (1.5 mg/kg). These results suggest that when lidocaine is administered locally in the cochlea it acts not only on the cochlear nerve but also on the outer hair cells.

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Prolonged suppression of tinnitus after peripheral nerve block using bupivacaine and lidocaine

Cited by 4 publications

References 7 publications

Tinnitus

Tinnitus

Intratympanic bupivacaine instillation for tinnitus treatment?

Effects of Lidocaine on Basilar Membrane Vibration in the Guinea Pig

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