Prolonged survival after resection of a malignant melanoma metastatic to the stomach

Pector, Jean Claude; Crokaert, Françoise; Lejeune, Ferdinand; A, Gerard

doi:10.1002/1097-0142(19880515)61:10<2134::aid-cncr2820611033>3.0.co;2-y

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…It has been shown that successful complete resection of digestive tract metastases of malignant melanoma is beneficial. It offers good palliation with improvement of the global survival [30,54,[56][57][58][59]61,63,64]. Our present small series shows the advantage of complete resection of GI malignant melanoma metastases, when practicable.…”

Section: Discussionmentioning

confidence: 83%

Surgical management of distant melanoma metastases

Lejeune

Líénard

Salès

et al. 1992

Seminars in Surgical Oncology

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Disseminated melanoma remains a tumour that is poorly responsive to chemotherapy and radiotherapy. However, this review demonstrates that surgical removal of visceral metastases such as at the, lung or digestive sites, as well as the brain, yields consistent median survivals, often longer than 12 months, and long-term survivors. Such surgery is followed by little complication cost and low perioperative mortality. Our experience tends to confirm that complete debulking offers longer survivors as compared to partial. Also, one site of metastases, whatever its anatomical location, when operated on, gives a better chance for survival than when there are multiple sites.

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Section: Discussionmentioning

confidence: 83%

Surgical management of distant melanoma metastases

Lejeune

Líénard

Salès

et al. 1992

Seminars in Surgical Oncology

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“…On the other hand, in cases of metastatic tu-Longterm survival after resection of a gastric metastasis from transverse colon cancer : a case report mors arising from melanoma, Pector et al 25) reported the case of a patient who remained alive for >6 years after subtotal gastrectomy for gastric metastasis from malignant melanoma. Ihde and Coit 26) recommended that palliative surgery be considered for metastatic gastrointestinal tumors from melanoma because it was associated with low rates of operative mortality and morbidity.…”

Section: Discussionmentioning

confidence: 99%

Long-term survival after resection of a gastric metastasis from transverse colon cancer: a case report

Terashima

Watanabe

Kogure

et al. 2019

FJMS

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Metastatic neoplasms in the stomach from remote primary tumors are uncommon, and gastric metastases of colorectal origin are rare. We herein report a case of gastric metastasis originating from transverse colon cancer in a 61 -yearold female patient. Curative right extended hemicolectomy and partial gastrectomy were performed. Histologically, both the colon and stomach tumors were moderately to poorly differentiated adenocarcinoma with similar features. The postoperative TNM classification was stage IV disease (T4N0M1). The patient received 7 cycles of postoperative bevasizumab+FOLFOX (oxaliplatin plus an infusion of 5 -fluorouracil/levofolinate) therapy and 4 cycles of additional chemotherapy with bevacizumab+FOLFIRI (irinotecan plus an infusion of 5 -fluorauracil/levofolinate). The patient has a good quality of life with no signs of recurrence at seven years and four months after surgery.

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“…Surgery for melanoma lesions that are metastatic to the gastrointestinal tract is quite effective for controlling symptoms but it rarely leads to long-term survival [8,9]. …”

Section: Discussionmentioning

confidence: 99%

A patient with metastatic melanoma presenting with gastrointestinal perforation after dacarbazine infusion: a case report

et al. 2010

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IntroductionWe report a rare case of gastrointestinal perforation following dacarbazine infusion for metastatic melanoma. The condition is attributed to a responding malignant melanoma in the gastrointestinal tract.Case presentationA 52-year-old Caucasian man presented with abdominal pain and distension, malaise, night sweats, dysphagia and early satiety. A computed tomography scan showed massive ascites, lymphadenopathy and liver lesions suspect for metastases. An upper gastrointestinal endoscopy was performed and revealed multiple dark lesions of 5 mm to 10 mm in his stomach and duodenum.When his skin was re-examined, an irregular pigmented lesion over the left clavicle measuring 15 mm × 8 mm with partial depigmentation was found. Histological examination of a duodenal lesion was consistent with a diagnosis of metastatic melanoma. The patient deteriorated and his level of lactate dehydrogenase rapidly increased. The patient was started on systemic treatment with dacarbazine 800 mg/m2 every three weeks and he was discharged one day after the first dose. On the sixth day he was readmitted with severe abdominal pain. A chest X-ray showed the presence of free intraperitoneal air that was consistent with gastrointestinal perforation. His lactate dehydrogenase level had fallen from 6969U/L to 1827U/L, supporting the conclusion that the response of gastrointestinal metastases to dacarbazine had resulted in the perforation of the patient's bowel wall. A laparotomy was discussed with the patient and his family but he decided to go home with symptomatic treatment. He died 11 days later.ConclusionMelanoma can originate in, as well as metastasize to, the gastrointestinal tract. Gastrointestinal perforations due to responding tumors are a well-known complication of systemic treatment of gastrointestinal lymphomas. However, as the response rate of metastatic melanoma to dacarbazine is only 10% to 20%, and responses are usually only partial, perforation due to treatment response in metastatic melanoma is rare.Medical oncologists should be aware of the risk of bowel perforation after starting cytotoxic chemotherapy on patients with gastrointestinal metastases.

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Prolonged survival after resection of a malignant melanoma metastatic to the stomach

Abstract: A man who presented with a secondary gastric melanoma was alive more than 6 years after surgery.

Cited by 13 publications

References 4 publications

Surgical management of distant melanoma metastases

Surgical management of distant melanoma metastases

Long-term survival after resection of a gastric metastasis from transverse colon cancer: a case report

A patient with metastatic melanoma presenting with gastrointestinal perforation after dacarbazine infusion: a case report

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