Prolonged Tp-e interval and Tp-e/QT correlates well with modified Rodnan skin severity score in patients with systemic sclerosis

Okutucu, Sercan; Karakulak, Uğur Nadir; Aksoy, Hakan; Şabanoğlu, Cengiz; Hekimsoy, Vedat; Şahiner, Levent; Kaya, Ergün Barış; Akdoğan, Ali; Kabakçı, Giray; Aytemir, Kudret; Tokgözoğlu, Lâle; Oto, Ali̇

doi:10.5603/cj.a2016.0021

Cited by 19 publications

(10 citation statements)

References 30 publications

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“…In addition, significant correlations between modified Rodnan skin severity score (used to assess extent and severity of skin involvement in systemic sclerosis) and Tp-e as well as Tp-e/QT ratio were demonstrated. 35 However, in our SLE patients, both uncorrected and corrected Tp-e and Tp-e/QT values were not associated with SLICC/ACR-DI.…”

Section: Discussioncontrasting

confidence: 58%

Influence of disease severity and cardiac autonomic tone on ventricular repolarization and dispersion in electrocardiographic assessment of patients with systemic lupus erythematosus

Bienias

Ciurzyński

Kisiel

et al. 2020

Lupus

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Background There are no data on the influence of disease severity and cardiac autonomic tone on ventricular repolarization and dispersion in 24-hour Holter monitoring in systemic lupus erythematosus (SLE). Methods Consecutive 92 SLE and 51 healthy subjects were studied. The standard 12-lead electrocardiography (ECG), Holter monitoring with heart rate turbulence (HRT) and QT, Tp-e and Tp-e/QT ratio assessment (including corrected values) were performed. Subjects with conditions causing repolarization abnormalities or insufficient number of beats suitable for QT evaluation were excluded (17 SLE and 8 controls). Results Finally, 75 SLE and 43 sex- and age-matched controls were included to the study. In SLE patients, the median disease severity score (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR-DI)) was 3.0. The mean values of QTc, cTp-e and cTp-e/QTc were significantly higher in SLE patients than in controls. QTc ≥ 460 ms was observed in 18.7% of patients using standard ECG and in 58.7% using Holter monitoring. With Holter monitoring, patients with SLICC/ACR-DI >3.0 presented longer QTc than those with SLICC/ACR-DI ≤3.0 (418±15 vs. 409 ± 16, p = 0.04), while cTp-e and cTp-e/QTc values were similar. Patients with abnormal HRT presented longer cTp-e and higher cTp-e/QTc than those with normal HRT (92 ± 52 vs. 71 ± 16 ms, p = 0.04; 0.244 ± 0.126 vs. 0.187 ± 0.035, p = 0.03), while QTc values were similar. No differences in QT and Tp-e parameters were observed according to disease duration. Conclusion In SLE patients, Holter monitoring revealed QTc prolongation more frequently than standard ECG. Longer QTc values were observed in patients with more advanced disease, while increased cTp-e and cTp-e/QTc were related to cardiac autonomic dysfunction expressed by abnormal HRT.

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Section: Discussioncontrasting

confidence: 58%

Influence of disease severity and cardiac autonomic tone on ventricular repolarization and dispersion in electrocardiographic assessment of patients with systemic lupus erythematosus

Bienias

Ciurzyński

Kisiel

et al. 2020

Lupus

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“…21 Cardiac disease in SSc has been shown to be associated with skin fibrosis. 22,23 More patients with diffuse versus limited SSc demonstrate heart disease attributable to SSc. 24,25 Moreover, incident cardiomyopathy, symptomatic pericarditis, or an arrhythmia requiring treatment developed in 15% of 953 SSc patients with diffuse skin disease during a mean follow-up of 10 years.…”

Section: Introductionmentioning

confidence: 99%

Diffuse cardiac fibrosis quantification in early systemic sclerosis by magnetic resonance imaging and correlation with skin fibrosis

Lee¹,

Hinchcliff²,

Sarnari

et al. 2018

Journal of Scleroderma and Related Disorders

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“…We found that the patients with systemic sclerosis had a prolonged Tp-e interval and Tp-e/QT ratio compared with healthy subjects. Furthermore, this prolongation was well correlated with clinical severity score among patients with systemic sclerosis [2].…”

mentioning

confidence: 79%

“…We would like to thank the authors for the letter [1] regarding our manuscript entitled "Prolonged Tp-e interval and Tp-e/QT correlates well with modified Rodnan skin severity score in patients with systemic sclerosis" [2] published in "Cardiology Journal". We would also like to thank the Editor for the opportunity to respond to this letter.…”

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confidence: 99%

Pericardial effusion: The key point is the underlying etiology. Authors’ reply

et al. 2016

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Prolonged Tp-e interval and Tp-e/QT correlates well with modified Rodnan skin severity score in patients with systemic sclerosis

Abstract: Background: Ventricular arrhythmias can be seen in systemic sclerosis (SSc) p = 0.032) and p = 0.007, respectively) p = 0.001) and p = 0.001). p = 0.001) and CRP (b = 2.273, p = 0.027) were found to be significant independent predictors of p = 0.001) (Cardiol J 2016; 23, 3: 242-249)

Cited by 19 publications

References 30 publications

Influence of disease severity and cardiac autonomic tone on ventricular repolarization and dispersion in electrocardiographic assessment of patients with systemic lupus erythematosus

Influence of disease severity and cardiac autonomic tone on ventricular repolarization and dispersion in electrocardiographic assessment of patients with systemic lupus erythematosus

Diffuse cardiac fibrosis quantification in early systemic sclerosis by magnetic resonance imaging and correlation with skin fibrosis

Pericardial effusion: The key point is the underlying etiology. Authors’ reply

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