Prolonged University Outbreak of Meningococcal Disease Associated With a Serogroup B Strain Rarely Seen in the United States

Mandal, Sema; Wu, Henry M.; MacNeil, Jessica R.; Machesky, Kimberly; García, José Manuel Menéndez; Plikaytis, Brian D.; Quinn, Kim; King, Larry D.; Schmink, Susanna; Wang, Xin; Mayer, Leonard W.; Clark, Thomas A.; Gaskell, James R.; Messonnier, Nancy E.; DiOrio, Mary; Cohn, Amanda C.

doi:10.1093/cid/cit243

Cited by 67 publications

(44 citation statements)

References 17 publications

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“…There is now growing evidence that outbreaks of meningococcus group B are different from meningococcus C outbreaks as they may be prolonged [13]. Our outbreak fits this pattern and highlights that guidance that is predominantly based on experience of meningococcus C outbreaks may not always be appropriate for serogroup B outbreaks.…”

Section: Discussionsupporting

confidence: 62%

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Four-month outbreak of invasive meningococcal disease caused by a rare serogroup B strain, identified through the use of molecular PorA subtyping, England, 2013

et al. 2014

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Molecular PorA subtyping provides information that increasingly requires the adaptation of standard public health approaches to outbreak management. We report an outbreak of a rare subtype of meningococcal infection not previously identified in the United Kingdom (UK). The outbreak occurred in the Warwickshire area in England between February and June 2013. Molecular subtyping allowed the identification of additional cases, prompting an enhanced public health response that included efforts to identify potential social networks that might benefit from chemoprophylaxis. It also prompted swabbing to define nasopharyngeal carriage in the focal nursery and helped explain the unusual epidemiological pattern. Without subtyping to identify a link, the additional cases would have been managed as sporadic cases in accordance with current UK guidance.

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Section: Discussionsupporting

confidence: 62%

“…The authors concluded that it was likely that the strain was reintroduced by a regular non-household contact or unidentified close contact [12]. In addition, Mandal et al reported an outbreak of 13 cases between January 2008 and November 2010 [13].…”

Section: Introductionmentioning

confidence: 99%

Four-month outbreak of invasive meningococcal disease caused by a rare serogroup B strain, identified through the use of molecular PorA subtyping, England, 2013

et al. 2014

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“…The clinical presentation of Meningococcal sepsis with central nervous system's involvement is typical, but sometimes the classic symptoms may be absent or difficult to notice. Widespread petechial rash is an early typical finding [5]. The reported case 1 illustrates such a clinical presentation with a favorable outcome.…”

Section: Discussionmentioning

confidence: 75%

Two Cases of Meningococcal Sepsis Caused By Neisseria Meningitidis Serogroup B

Pekova¹

2016

Ann Clin Anal Med

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Thirteen serogroups of bacterium Neisseria meningitidis (N. meningitidis) have been identified, but 5 of them -A, B, C, W-135 and Y -are responsible for majority of the infections worldwide. Serogroup B meningococcus is uncommon in Bulgaria. In 2014 two cases of meningococcal sepsis caused by N. meningitidis serogroup B were diagnosed and treated in the Clinic of Infectious Diseases of University Hospital of Stara Zagora, Bulgaria. They were 10-months old female and 1-year old male. The diagnosis was based on the clinical, epidemiological, laboratorial, microbiological and molecular-genetic analysis. Both cases presented with a sudden oncet of fever, marked asthenia, refusing feeds and hemorrhagic-necrotic skin rash. In the first case the disease evolved to meningococcal sepsis with meningitis with a favorable outcome. The second case rapidly developed fulminant meningococcal sepsis without meningitis with a lethal outcome. In both cases N. meningitidis serogroup B as etiological agent was confirmed.

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“…While outbreaks of IMD are more commonly associated with serogroup C disease [5,21], prolonged community based and institutional outbreaks of serogroup B disease have been described [22,23]. Control measures in these outbreaks differed.…”

Section: Discussionmentioning

confidence: 99%

A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013

O’Connor¹,

Ward²,

Bennett

et al. 2015

Eurosurveillance

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Prolonged University Outbreak of Meningococcal Disease Associated With a Serogroup B Strain Rarely Seen in the United States

Cited by 67 publications

References 17 publications

Four-month outbreak of invasive meningococcal disease caused by a rare serogroup B strain, identified through the use of molecular PorA subtyping, England, 2013

Four-month outbreak of invasive meningococcal disease caused by a rare serogroup B strain, identified through the use of molecular PorA subtyping, England, 2013

Two Cases of Meningococcal Sepsis Caused By Neisseria Meningitidis Serogroup B

A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013

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