PROMETHEUS: an observational, cross-sectional, retrospective study of hypertriglyceridemia in Russia

IuA, Karpov; Khomitskaya, Yunona

doi:10.1186/s12933-015-0268-2

Cited by 33 publications

(22 citation statements)

References 54 publications

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“…Additionally, hypertriglyceridemia was independently associated with diabetes mellitus. A similar association between hypertriglyceridemia and HbA1c was reported in a Russian study [ 17 ].…”

Section: Discussionsupporting

confidence: 86%

The Prevalence of Dyslipidemia among Jordanians

et al. 2018

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Background Dyslipidemia is one of the major modifiable risk factors for the development of cardiovascular disease and type two diabetes mellitus. Knowing the current prevalence of dyslipidemia is an important step for increasing awareness of the problem and for proper planning of health programs for prevention of its negative clinical effects. Methods A national population based household sample was selected from north, middle, and south regions of Jordan in 2017. A total sample of 4,056 aged between 18 and 90 years were included. Selected individuals were interviewed using a structured questionnaire and fasting blood samples were collected for biochemical measurements. Results The prevalence rates of hypercholesterolemia, hypertriglyceridemia, high LDL, and low HDL were 44.3%, 41.9% 75.9%, and 59.5%, respectively. Hypercholesterolemia in Jordan almost doubled from 23.0% in 1994 to 44.3% in 2017, and hypertriglyceridemia increased from 23.8% in 1994 to 41.9% in 2017. All lipid abnormalities decreased after the age of 60 years. Hypertension, diabetes, and obesity were all independently associated with hypercholesterolemia and hypertriglyceridemia. Conclusions Results of this study show that dyslipidemia is a widely prevalent health problem among adult Jordanian population and that the problem has substantially increased since 1994. Encouraging healthy lifestyle and healthy diet are the basis for prevention of dyslipidemia.

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Section: Discussionsupporting

confidence: 86%

The Prevalence of Dyslipidemia among Jordanians

et al. 2018

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“…The risk of AP in patients with serum triglycerides > 1000 and >2000 mg/dL is ~5% and 10% to 20%, respectively [ 18 ]. The prevalence of HTG is high in developed countries such as the United States and Russia but with rare severe ones [ 19 , 20 ]. A common cause of HTG is seen in conditions with insulin resistance, such as metabolic syndrome (MetS) and type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Etiology of Acute Pancreatitis in Urban and Suburban Areas in Shanghai: A Retrospective Study

Fan

Ding

Lǚ

et al. 2018

Gastroenterology Research and Practice

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Aim To investigate the epidemiology, etiology, and severity of acute pancreatitis (AP) in urban and suburban areas of Shanghai in 2011 and 2016. Methods A retrospective study of patients admitted to Shanghai General Hospital (urban and suburban campuses) with AP in 2011 and 2016 was undertaken. Patients were divided into acute biliary pancreatitis (ABP), hypertriglyceridemic pancreatitis (HTGP), alcoholic pancreatitis, and pancreatitis of other causes according to etiology. Severity of AP was divided into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP). Results AP patients in the suburban area increased more rapidly than those in the urban area. The mean onset age of AP in the urban area in 2016 was older than that in the suburban area (p < 0.05). The suburban patients in 2016 have significantly younger mean onset age than those in 2011 (p < 0.05). HTGP incidence in suburban patients increased from 2011 to 2016, which changed little in the urban area. Urban females were more likely to develop HTGP than suburban ones in 2011, which reversed in 2016. As to the male patients, the incidence of HTGP increased in both urban and suburban areas. Nonelderly (<60 years old) patients had higher HTGP incidence than elderly ones in both 2011 and 2016. The descending trend of SAP in the suburban area was more obvious than that in the urban area. The length of hospitalization decreased from 2011 to 2016, especially in SAP patients. Conclusions AP patients increased more rapidly in the suburban area of Shanghai with younger onset age. The incidence of HTGP increased significantly in the suburban area, reminding of the prevention and screening of HTG.

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“…The Prevalence of Mixed Dyslipidemia and Severe Hypertriglyceridemia in the Russian Population (PROMETHEUS) study found that almost one-third of Russians have hypertriglyceridemia, defined as a triglyceride level ≥ 1.7 mmol/l, and identified correlations between levels of triglycerides and those of TC, LDL-C, high-density lipoprotein cholesterol (HDL-C), and HbA1c [ 9 ]. A further observational, cross-sectional study of Russian participants, the Centralized Survey on the Undertreatment of Hypercholesterolemia in Russia (CEPHEUS), was conducted between October 2010 and March 2011, and assessed the use and effectiveness of lipid-lowering drugs in 1000 individuals [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Suboptimal control of lipid levels: results from the non-interventional Centralized Pan-Russian Survey of the Undertreatment of Hypercholesterolemia II (CEPHEUS II)

Boytsov

Логунова²,

Khomitskaya³

2017

Cardiovasc Diabetol

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BackgroundElevated levels of low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin (HbA1c) are risk factors for cardiovascular complications. This study evaluated LDL-C goal attainment in Russian clinical practice among patients with moderate to very high cardiovascular risk. The study also assessed LDL-C goal attainment in patients prescribed lipid-lowering therapy for primary compared with secondary cardiovascular disease (CVD) prevention, predictors of LDL-C goal attainment, and the proportion of individuals with diabetes mellitus who achieved HbA1c < 7%.MethodsThe Centralized Pan-Russian Survey on the Undertreatment of Hypercholesterolemia in Russia II (CEPHEUS II) was a multicenter, non-interventional, cross-sectional study conducted in the Russian Federation from September 2014 to November 2015. Participants were aged ≥ 18 years, were receiving a stable dose of lipid-lowering medication and had a moderate to very high cardiovascular risk. The primary variable was the proportion of patients reaching LDL-C goals established by the Fifth Joint European Task Force guidelines. Secondary analyses used McNemar and χ2 tests.ResultsData from 2703 patients were analyzed; 91.2% had a very high cardiovascular risk and 24.0% had been diagnosed with diabetes mellitus. Overall, 17.4% of patients (95% confidence interval [CI] 15.9–18.8%) achieved LDL-C goals. Investigators estimated this proportion at 21.8% (95% CI 20.3–23.4%). LDL-C goals were achieved by more patients in the primary CVD prevention subgroup than in the secondary CVD prevention subgroup (19.7% vs 16.1%, p = 0.017). Patient-related factors associated with a decreased likelihood of achieving LDL-C goals included having ischemic heart disease or a family history of premature coronary heart disease, forgetting to take hypercholesterolemia treatment or considering it acceptable to miss prescribed doses more than once per week, and dissatisfaction with or concern about lipid-lowering therapy. Overall, 367/593 (61.9%) patients with diabetes mellitus and interpretable HbA1c results achieved HbA1c < 7%.ConclusionsHypercholesterolemia management is suboptimal in patients with moderate to very high cardiovascular risk in Russian clinical practice. Substantial opportunity remains to improve treatment target attainment and reduce the risk of cardiovascular complications. Lipid-modifying strategies may need to be intensified to reduce CVD risk in this setting. Trial registration ClinicalTrials.gov: NCT02230241 (registered 26 August 2014)Electronic supplementary materialThe online version of this article (10.1186/s12933-017-0641-4) contains supplementary material, which is available to authorized users.

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PROMETHEUS: an observational, cross-sectional, retrospective study of hypertriglyceridemia in Russia

Cited by 33 publications

References 54 publications

The Prevalence of Dyslipidemia among Jordanians

The Prevalence of Dyslipidemia among Jordanians

Epidemiology and Etiology of Acute Pancreatitis in Urban and Suburban Areas in Shanghai: A Retrospective Study

Suboptimal control of lipid levels: results from the non-interventional Centralized Pan-Russian Survey of the Undertreatment of Hypercholesterolemia II (CEPHEUS II)

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