Prominent Eye Movements During NREM Sleep and REM Sleep Behavior Disorder Associated with Fluoxetine Treatment of Depression and Obsessive-Compulsive Disorder

Abstract

Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive.

The Effects of Fluoxetine on the Polysomnogram of Depressed Outpatients: A Pilot Study

“…The duration of REM sleep and REM latency, as well as REM density, may also be affected by FLU (Nicholson and Pascoe 1988;von Bardeleben et al 1989;Nicholson et al 1989; Bakalian and Fernstrom 1990;Hanzel et al 1991;Saletu et al 1991). These effects likely depend upon both the dose and duration of FLU treatment.Changes in polysomnogram (PSG) measures as sociated with chronic FLU treatment in depressed sub jects have been incompletely studied (Schenck et al 1992). Relationships among PSG measures and serum concentrations of FLU and its active metabolite norflu oxetine (NFLU) have not been previously reported in depressed patients.…”

“…Changes in polysomnogram (PSG) measures as sociated with chronic FLU treatment in depressed sub jects have been incompletely studied (Schenck et al 1992). Relationships among PSG measures and serum concentrations of FLU and its active metabolite norflu oxetine (NFLU) have not been previously reported in depressed patients.…”

Effects of Prior Fluoxetine Treatment on ? Sleep in Women with Recurrent Depression

“…Uncontrolled studies have noted eye movements during NREM sleep which may persist for as long as 19 months after fluoxetine discontinuation (Schenck et al 1992;Winkelman et al 1992). Such changes could be viewed as persistent neuronal adaptations to acute changes in serotonergic transmission caused by fluoxetine administration.…”

“…Fluoxetine is also associated with modest reductions in sleep efficiency, rapid eye movement (REM) sleep percentage, and stage 3/4 nonrapid eye movement (NREM) sleep percentage, and with increases in wakefulness, Stage 1 NREM sleep percentage, and the number of eye movements during REM sleep (Armitage et al 1997a;Gillin et al 1997;Stokes 1995;Hendrickse et al 1994;Kerkhofs et al 1990). Other PSG effects noted with fluoxetine include periodic limb movements and prominent eye movements during NREM sleep (Schenck et al 1992;Armitage et al 1995;Dorsey et al 1996). …”

“…Uncontrolled studies have indeed suggested that some PSG effects of fluoxetine may persist for up to 19 months after discontinuation (Schenck et al 1992;Winkelman et al 1992), but no controlled studies have been performed. It is difficult to know from these reports whether sleep changes associated with prior fluoxetine treatment actually represent persistent effects of the drug, discontinuation effects, or some form of neuroadaptation caused by prior drug administration.…”