Prominent lymphoid infiltrate with a pseudolymphoma‐like morphology: a new histological finding of injectable liquid silicone

Michaels, B.D.; Michaels, Jason; Mobini, Narciss

doi:10.1111/j.1600-0560.2009.01328.x

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…35 Indeed, chronic stimulation of B cells by the silicone implants may lead to the formation of pseudo-lymphoma which precede the development of the well-defined non-Hodgkin lymphoma. 36,37 . Most of the autoimmune diseases and especially noted in Sjögren’s disease are associated with higher rates of non-Hodgkin.…”

Section: Asia Syndrome and Siliconementioning

confidence: 99%

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome) – An update

Watad

Quaresma

Brown

et al. 2017

Lupus

133

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been widely described in many studies conducted thus far. The syndrome incorporates five immune-mediated conditions, all associated with previous exposure to various agents such as vaccines, silicone implants and several others. The emergence of ASIA syndrome is associated with individual genetic predisposition, for instance those carrying HLA-DRB1*01 or HLA-DRB4 and results from exposure to external or endogenous factors triggering autoimmunity. Such factors have been demonstrated as able to induce autoimmunity in both animal models and humans via a variety of proposed mechanisms. In recent years, physicians have become more aware of the existence of ASIA syndrome and the relationship between adjuvants exposure and autoimmunity and more cases are being reported. Accordingly, we have created a registry that includes at present more than 300 ASIA syndrome cases that have been reported by different physicians worldwide, describing various autoimmune conditions induced by diverse adjuvants. In this review, we have summarized the updated literature on ASIA syndrome and the knowledge accumulated since 2013 in order to elucidate the association between the exposure to various adjuvant agents and its possible clinical manifestations. Furthermore, we especially referred to the relationship between ASIA syndrome and systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS).

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Section: Asia Syndrome and Siliconementioning

confidence: 99%

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome) – An update

Watad

Quaresma

Brown

et al. 2017

Lupus

133

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“…У пациентов с грудными имплантатами силикон может стимулировать развитие аутоиммунных заболеваний во многом за счет дисрегуляции гуморального иммунного ответа. В итоге J. Cohen Tervaert и R. Kappel [28][29][30] подчеркнули, что имплантаты сами по себе безвредны, но перед их установкой необходимо тщательное обследование больных для исключения возможных противопоказаний, которые впоследствии будут определяющими при развитии ASIA. Авторы пришли к выводу, что силиконсодержащие грудные имплантаты могут увеличивать риск развития аутоиммунных заболеваний и состояний иммунодефицита.…”

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Autoimmune/inflammatory syndrome induced by adjuvants

Раденска-Лоповок

Volkova

2018

Arkh. patol.

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Аутоиммунный/воспалительный синдром, вызванный адъювантами (ASIA-Autoimmune/Inflammatory Syndrome Induced by Adjuvants), впервые описан в 2011 г. Y. Shoenfeld и N. Agmon-Levin [1] в связи с необходимостью объединить ряд заболеваний, характеризующихся общим механизмом развития и вызванных различными адъювантами. В литературе это состояние также называют синдромом Шонфельда (Shoenfeld's syndrome). Выделение ASIA позволило впервые сгруппировать специфические состояния, в основе патогенеза которых лежит гиперергическая реакция иммунной системы в ответ на различные адъюванты. К подобным состояниям относят силиконоз, макрофагальный миофасциальный синдром, синдром Персидского залива, синдром «больных» зданий, и поствакцинальный феномен и др. [2, 3]. С момента введения ASIA было диагностировано более 4000 клинических случаев [4]. Большинство из них ассоциировано с введением различных вакцин (вакцины против папилломавируса человека, гриппа и др.), а также с установкой силиконовых имплантатов и использованием косметических филлеров, содержащих минеральные масла [5-7]. Адъюванты-это вещества, стимулирующие, ускоряющие и пролонгирующие иммунный ответ при совмест

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications

Seida

Alrais

Seida

et al. 2023

Clinical and Experimental Immunology

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Summary Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning as when added to vaccines they are meant to boost the effect and strongly stimulate the immune system. The response of the immune system can be unpredictable, and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed to address possible adverse reactions of an autoimmune and inflammatory type that may be caused by adjuvants. While ASIA, as a syndrome, was coined and defined in 2011; reports describing patients with vague and nonspecific clinical symptoms following vaccinations appeared much earlier. In other words, ASIA came to define, arrange, and unite the variety of symptoms, related to autoimmunity, caused not by the vaccine itself, rather by the adjuvant part of the vaccine such as aluminum, among others. Accordingly, the introduction of ASIA enabled better understanding, proper diagnosis, and early treatment of the disorder. Furthermore, ASIA was shown to be associated with almost all body systems and various rheumatic and autoimmune diseases such as SLE, APS, and systemic sclerosis. In addition, the correlation between COVID-19 and ASIA was noticed during the pandemic. In this review, we summarized the reported effects of adjuvants and medical literature before and after ASIA was defined, the several ways ASIA can manifest and impact different systems of the body, and the incidences of ASIA during the COVID-19 pandemic. It is important to clarify, that vaccines are among, if not the, most effective means of fighting infectious diseases however, we believe that vaccines manufacturing is not above criticism, particularly when it comes to added substances possessing a risk of side effects.

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Prominent lymphoid infiltrate with a pseudolymphoma‐like morphology: a new histological finding of injectable liquid silicone

Cited by 3 publications

References 8 publications

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome) – An update

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome) – An update

Autoimmune/inflammatory syndrome induced by adjuvants

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications

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