Prominent role of low HDL-cholesterol in explaining the high prevalence of the metabolic syndrome in polycystic ovary syndrome

Gambineri, Alessandra; Repaci, Andrea; Patton, Laura; Grassi, Ilaria; Pocognoli, Patrizia; Cognigni, G.E.; Pasqui, Francesca; Pagotto, Uberto; Pasquali, Renato

doi:10.1016/j.numecd.2009.01.007

Cited by 43 publications

(51 citation statements)

References 35 publications

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“…9,10,[25][26][27] Prevalence of the MetS using three criteria within our PCOS women was in the range of 16.2 to 19.4% and is similar to the prevalence in other Europid populations. 10,26,28 There is a universally established relationship obesity and the MetS.…”

Section: Discussionsupporting

confidence: 80%

“…However, analyzed PCOS subjects were predominantly overweight or obese. [8][9][10] Although excessive weight predominates among PCOS women assessed for the presence of MetS, it is assumed that PCOS women have an increased risk for the metabolic syndrome that is independent of insulin resistance or obesity. 10,11 As the diagnosis of MetS is established from the combination of anthropometric and laboratory measures, there is a need for the simplest and the most accurate method of assessment of risk factors to which PCOS women are exposed during the long period of transition from subclinical to overt cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

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Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome

Macut¹,

Antić²,

Bjekić-Macut³

et al. 2015

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oBJectIVe: there is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (Pcos). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that yield an estimation of lipid overaccumulation. we aimed to determine whether LAP is associated with metabolic syndrome (Mets) in caucasian women with Pcos. desIGn: we studied 222 women with Pcos who were diagnosed using the Rotterdam criteria. In all the subjects and controls, LAP was determined and the Mets was assessed using three different international criteria, nceP-AtP III, Idf, and JIs. Roc curve and logistic regression analyses were performed to determine and analyze associations with the Mets. ResuLts: In the study population the prevalence of Mets was 16.2-19.4%. the cut-off value of 25.9 determined that LAP has the strongest association with Mets whichever international criteria are used, followed by HdL (nceP-AtP III and JIs) and glucose (Idf). concLusIons: LAP is used as an independent clinical indicator for Mets in our Pcos women of caucasian origin. the high diagnostic accuracy of LAP is superseding the need for the use of multiple clinical indicators for the assessment of lipid accumulation as a prerequisite for diagnosis of metabolic and cardiovascular diseases in Pcos women.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome

Macut¹,

Antić²,

Bjekić-Macut³

et al. 2015

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“…Usually, women with classic PCOS are characterised by higher body weight, but when comparisons were made between groups matched for age and BMI, it was obvious that the degree of dyslipidaemia, central adiposity, insulin resistance and metabolic syndrome prevalence was significantly higher in women with the classic (or more severe) PCOS phenotype. The prevalence of metabolic syndrome and degree of insulin resistance in the milder phenotype (oligo-anovulatory patients with PCOm but without hyperandogenaemia), although elevated (28), are closer to control subjects than to the other three phenotypes (29). Specifically, women with this phenotype usually display normal insulin sensitivity and a metabolic profile similar to ageand BMI-matched normal women.…”

Section: The Debate On the Definition Of Pcosmentioning

confidence: 90%

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology

Conway¹,

Dewailly²,

Diamanti-Kandarakis³

et al. 2014

European Journal of Endocrinology

576

492

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Polycystic ovary syndrome (PCOS) is the most common ovarian disorder associated with androgen excess in women, which justifies the growing interest of endocrinologists. Great efforts have been made in the last 2 decades to define the syndrome. The presence of three different definitions for the diagnosis of PCOS reflects the phenotypic heterogeneity of the syndrome. Major criteria are required for the diagnosis, which in turn identifies different phenotypes according to the combination of different criteria. In addition, the relevant impact of metabolic issues, specifically insulin resistance and obesity, on the pathogenesis of PCOS, and the susceptibility to develop earlier than expected glucose intolerance states, including type 2 diabetes, has supported the notion that these aspects should be considered when defining the PCOS phenotype and planning potential therapeutic strategies in an affected subject. This paper offers a critical endocrine and European perspective on the debate on the definition of PCOS and summarises all major aspects related to aetiological factors, including early life events, potentially involved in the development of the disorder. Diagnostic tools of PCOS are also discussed, with emphasis on the laboratory evaluation of androgens and other potential biomarkers of ovarian and metabolic dysfunctions. We have also paid specific attention to the role of obesity, sleep disorders and neuropsychological aspects of PCOS and on the relevant pathogenetic aspects of cardiovascular risk factors. In addition, we have discussed how to target treatment choices based according to the phenotype and individual patient's needs. Finally, we have suggested potential areas of translational and clinical research for the future with specific emphasis on hormonal and metabolic aspects of PCOS.

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“…Aromatase deficiency, a rare disorder in which affected individuals cannot synthesize endogenous estrogen, is associated with metabolic abnormalities including obesity in humans (Jones et al 2007). In women, it is well known that hyperandrogenism is often associated with increased intra-abdominal fat accumulation and the metabolic syndrome (as for the case of polycystic ovary syndrome; Gambineri et al 2009), and the decline of estrogen after menopause is known to determine an increase in intraabdominal fat mass (Lobo 2008). In men, testosterone deficiency in hypogonadic individuals is associated with a significant change in body composition (especially featured by an increase in fat mass) and with the frequent presence of dysmetabolisms (Barrett-Connor 1992, Barud et al 2002, Grossmann et al 2010, Traish et al 2011.…”

Section: Brown Adipose Tissue and Obesitymentioning

confidence: 99%

Role of sex hormones in modulation of brown adipose tissue activity

Quarta

Mazza²,

Pasquali³

et al. 2012

Journal of Molecular Endocrinology

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The recent demonstration that metabolically active brown adipose tissue (BAT) is present with a high prevalence in humans undoubtedly represents one of the major advancements in the field of metabolic research in the last few years. The increasing interest in BAT is justified by preclinical observations highlighting an important role of this tissue in energy dissipation and metabolic clearance of substrates from the blood. These findings imply that stimulation of BAT activity may represent a new therapeutic approach for obesity and associated comorbidities. However, before proposing BAT as a target organ for therapeutics in a clinical setting, many further notions about BAT function and modulation need to be explored. Keeping in mind the importance of sex dimorphism in energy metabolism control under physiological and pathological conditions, sex hormones may play a relevant role in the regulation of BAT activity in both males and females. Much of the evidence acquired in the past supports the concept of an important role for different sex hormones in BAT thermogenesis and indicates that this tissue mediates the ability of sex hormones to modulate energy balance. These findings make it plausible that a modified interaction between BAT and sex hormones may contribute to the development and the maintenance of obesity and associated metabolic complications.Journal of Molecular Endocrinology (2012) 49, R1-R7

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Prominent role of low HDL-cholesterol in explaining the high prevalence of the metabolic syndrome in polycystic ovary syndrome

Cited by 43 publications

References 35 publications

Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome

Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology

Role of sex hormones in modulation of brown adipose tissue activity

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