Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice

Dong, Zhao; Brown, Allison A.; Wagner, Denisa D.

doi:10.1161/01.cir.101.19.2290

Cited by 241 publications

(172 citation statements)

References 47 publications

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“…In case -control studies, soluble P-selectin concentrations are elevated in conditions of accelerated atherosclerosis and thrombosis (Blann et al, 2000;Frijns et al, 1997;Tsakiris et al, 1999;Xu et al, 1998). Furthermore, results of animal studies suggest that P-selectin plays a critical role in atherogenesis (Dong et al, 1998(Dong et al, , 2000. Although P-selectin is expressed on both endothelial cells and platelets, soluble P-selectin is unlikely to arise from the endothelium, and is more likely to be released from activated platelets (Blann et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans

et al. 2001

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Objective: To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules. Design: Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the duration of the study. During a 4-week baseline period all subjects drank 5 cups=day (250 ml) of hot water. The effects of 5 cups=day of black tea for 4 weeks were then compared with hot water. Platelet aggregation in response to three doses of collagen and ADP, plasma concentrations of coagulation and fibrinolytic factors (fibrinogen, factor VII, tPA, PAI-1) and plasma concentrations of cell adhesion molecules (soluble P-selectin, E-selectin, ICAM-1, VCAM-1) were assessed twice, one week apart, at the end of each period. Twenty-four hour urinary concentration of 4-O-methylgallic acid (4OMGA), assessed once at the end of each period, was used as a marker of black tea polyphenol intake. Results: The 24 h urinary excretion of 4OMGA was increased during regular ingestion of black tea in comparison to hot water (P<0.0001). Black tea resulted in lower soluble P-selectin (P ¼ 0.01) in comparison to hot water, but did not influence other adhesion molecules. Soluble P-selectin was significantly correlated with mean collagenstimulated platelet aggregation at baseline (r ¼ 0.61, P ¼ 0.003), and during regular ingestion of hot water (r ¼ 0.70, P<0.0001) and black tea (r ¼ 0.51, P ¼ 0.01). However, platelet aggregation was not different between the black tea and hot water periods for collagen-or ADP-stimulated aggregation at any dose. Coagulation and fibrinolytic factors were also not different between periods. Conclusions: The effect of black tea on soluble P-selectin provides a potential mechanism for cardiovascular benefits of regular ingestion of tea.

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Section: Discussionmentioning

confidence: 99%

Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans

et al. 2001

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“…Inhibition of leukocyte recruitment slows development of atherosclerosis. Indeed, P-selectin knockout mice have smaller lesions than control animals (Dong et al, 2000). NF-κB regulates expression of P-selectin and other inflammation-related genes including E-selectin, ICAM-1, VCAM-1, and MCP-1 (Cominacini et al, 1997).…”

Section: Nf-κb Response To Oxldl and Atherosclerosismentioning

confidence: 99%

Role of Oxidized Lipids in Atherosclerosis

Garelnabi¹,

Kakumanu²,

Litvinov³

2012

Oxidative Stress and Diseases

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“…It has been suggested that P-selectin may be involved in atherosclerosis because P-selectin deficiency delays and reduces atherosclerotic lesion formation. 7,8 Much interest has also been given to soluble P-selectin since this was first proposed to be a marker of platelet activation in 1997. 9 Recent evidence suggests that soluble P-selectin may play a key role in hemostasis and thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP

Cleator

Zhu

Vaughan

et al. 2006

Blood

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Thrombin-mediated endothelial-cell release of von Willebrand factor (VWF) and P-selectin functionally links proteaseactivated receptors (PARs) to thrombosis and inflammation. VWF release can be stimulated by both Ca 2؉ and cAMP, and, although both VWF and P-selectin are found in Weibel-Palade bodies (WPBs), we found that their release could be differentially regulated. In these studies, human umbilical vein endothelial cells stimulated with cAMP or PAR2-AP led to a delayed release of VWF and significantly less P-selectin release compared with histamine, thrombin, or PAR1-AP. Doseresponse studies revealed that PAR2-AP was significantly less efficacious in promoting the release of P-selectin compared with VWF. PAR2-AP-induced robust stimulation of intracellular Ca 2؉ coupled with a significantly greater inhibitory effect of calcium chelation on release of VWF compared with cell-surface expression of P-selectin, suggests an additional Ca 2؉ -independent pathway involved in release of P-selectin. PAR2-AP failed to increase global cAMP levels; however, inhibition of protein kinase A

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Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice

Cited by 241 publications

References 47 publications

Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans

Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans

Role of Oxidized Lipids in Atherosclerosis

Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP

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