2013
DOI: 10.1515/nanoph-2012-0026
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Promises and challenges of nanoplasmonic devices for refractometric biosensing

Abstract: Optical biosensors based on surface plasmon resonance (SPR) in metallic thin films are currently standard tools for measuring molecular binding kinetics and affinities – an important task for biophysical studies and pharmaceutical development. Motivated by recent progress in the design and fabrication of metallic nanostructures, such as nanoparticles or nanoholes of various shapes, researchers have been pursuing a new generation of biosensors harnessing tailored plasmonic effects in these engineered nanostruct… Show more

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Cited by 88 publications
(76 citation statements)
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References 138 publications
(189 reference statements)
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“…While our sensitivity and FOM calculations are consistent with literature and comparable to other plasmonic sensors 6,27,42 , further optimization is desirable and possible 58 . In our case, the buried surface of the sensor is still an as-deposited rough metal film (in contrast to the ultrasmooth sensing surface), which could account for a loss of sensitivity ( i.e.…”
Section: Resultssupporting
confidence: 85%
“…While our sensitivity and FOM calculations are consistent with literature and comparable to other plasmonic sensors 6,27,42 , further optimization is desirable and possible 58 . In our case, the buried surface of the sensor is still an as-deposited rough metal film (in contrast to the ultrasmooth sensing surface), which could account for a loss of sensitivity ( i.e.…”
Section: Resultssupporting
confidence: 85%
“…The physicochemical properties of nanomaterials influenced by protein corona include surface properties, aggregation properties and hydrodynamic size charge; in the meantime, the adhered proteins can endure conformational alternation, functionality changes, unmasking of new epitopes and alternations in avidity and affinity effects (Cedervall et al, 2007; Luyts et al, 2013; Nel et al, 2009). In contrast to using centrifugation, a conventional method that likely disturbs protein–NP complexes, a number of methodologies, including size-exclusion chromatography gel filtration, ITC, surface plasmon resonance (SPR), have been proposed for measuring dynamic and equilibrium parameters of the protein–NP interactions and estimating the potential of NP-associated risks (Cedervall et al, 2007; Dahlin et al, 2013). …”
Section: Characterization Of Nanomaterialsmentioning
confidence: 99%
“…[ 20,35 ] (Around one for the HEHB mode, which is higher than for the corresponding structure with a single Au fi lm. [ 4 ] For instance, one can operate in fl ow-through confi guration [ 16 ] and direct binding to the interior of the pores. [ 43 ] Thus, from a performance point of view, the MIM nanopores seem suitable although not superior for refractometric sensing applications.…”
Section: Refractive Index Sensingmentioning
confidence: 99%