Promising Anti-atherosclerotic Effect of Berberine: Evidence from In Vitro, In Vivo, and Clinical Studies

Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management

“…lipidemic, anti-inflammatory and immunosuppressive effects. [14][15][16][17][18][19] There is growing evidence that berberine can ameliorate adjuvant-induced arthritis (AIA) and/or collagen-induced arthritis (CIA) in experimental animals witnessed through the immunomodulatory effects and the suppression of numbers of inflammatory signalling cascades involved in the joint inflammation and bone destruction.…”

Effects of Berberine on Atherosclerosis

“…Many traditional herbs inhibit the phenotype switching of VSMCs in atherosclerosis; examples include chocolate vine, garlic, and mountain asparagus (Saleh Al-Shehabi et al, 2016). Numerous studies have shown that berberine inhibited VSMCs proliferation and migration induced by multiple stimuli (Fatahian et al, 2020;Wu et al, 2020;Zhang et al, 2021), but whether berberine could inhibit the switching of VSMCs from contractile to synthetic phenotypes to reduce atherosclerosis has not been reported and must be explored.…”

Berberine as a promising natural compound for the treatment of periodontal disease: A focus on anti‐inflammatory properties

“… 18 Studies over the past two decades have provided important evidence on the polytrophic pharmacological effects of BBR including anti‐microbial, anti‐oxidant, anti‐tumour, and anti‐inflammatory, and anti‐diabetic activities. 14 , 19 , 20 , 21 Interestingly, a considerable amount of research studies have been published on the immunomodulatory effects of BBR in the immune system. 19 , 22 These studies have confirmed that BBR’s anti‐inflammatory effect arises from its interaction with different types of immune cells including keratinocytes, epithelial cells, DCs, macrophages, mast cells, and T and B cells.…”

“…The past two decades have seen increasingly rapid advances in the field of pharmacology using naturally occurring medicine. 13 , 14 , 15 , 16 In this regard, mounting evidence has addressed the potential anti‐inflammatory properties of berberine (BBR), a bioactive alkaloid compound isolated from Coptidis rhizoma , in controlling or treating several inflammatory diseases. For the first, this paper provides an overview of BBR’s anti‐inflammatory effects and its therapeutic potential for the treatment of periodontitis.…”