Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions

Panda, Mrunmaya Kumar; Paul, Manish; Singdevsachan, Sameer Kumar; Tayung, Kumananda; Das, Swagat Kumar; Thatoi, Hrudayanath

doi:10.2174/1389201021666201008164056

Cited by 7 publications

(3 citation statements)

References 186 publications

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“…Specifically, several epidemiological studies indicated that mushroom intake can protect against cancer, in particular, gastrointestinal and breast cancer. Furthermore, mushrooms have been used as therapeutic agents for different types of cancer, including breast cancer [ 31 , 58 , 153 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Gariboldi,

Marras,

Ferrario

et al. 2023

IJMS

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Edible/medicinal mushrooms have been traditionally used in Asian countries either in the cuisine or as dietary supplements and nutraceuticals. In recent decades, they have aroused increasing attention in Europe as well, due to their health and nutritional benefits. In particular, among the different pharmacological activities reported (antibacterial, anti-inflammatory, antioxidative, antiviral, immunomodulating, antidiabetic, etc.), edible/medicinal mushrooms have been shown to exert in vitro and in vivo anticancer effects on several kinds of tumors, including breast cancer. In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action. In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus. We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Gariboldi,

Marras,

Ferrario

et al. 2023

IJMS

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“…Later on, edible mushrooms got popular due to their health benefits (Baruah, 1998;Chatterjee, 2017;Li, 2021). Other studies were also undertaken on glucans from mushrooms (Roy, 2009;Ojha, 2010;Sen, 2013), anticancer therapeutics (Panda, 2021), lignocellulosic degradation of the spent mushroom substrate (Devi, 2020).…”

Section: Introductionmentioning

confidence: 99%

Study of Vitamin D2 accumulation potential of two edible mushrooms from North-East India

Begum¹,

Ghosh²,

Saikia³

2022

EEC

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Vitamin D is a fat-soluble vitamin that plays an important role in calcium absorption from the intestinecontributing to bone health and many other functions leading to health improvement. There are mainlytwo forms of Vitamin D, namely Vitamin D3 (Cholecalciferol) and Vitamin D2 (Ergocalciferol). Ergocalciferol(Vitamin D2) is a form of Vitamin D found in food, especially mushrooms. Mushrooms contain ergosterolin their cell membrane; exposure to sunlight/ultraviolet (UV) light causes a photochemical reaction thatisomerizes ergosterol to Vitamin D2. Mushrooms are extensively grown in North-East India from timeimmemorial by the ethnic people. In this study, Vitamin D2 from fruiting bodies of two Oyster Mushroomspecies, namely Pleurotus florida and Pleurotus cornucopiae, is quantified using a spectrophotometer at 264nm.This study aimed to determine the Vitamin D2 accumulation potential of both the species and to select thebest species with the highest Vitamin D2 accumulation potential. Fresh cultures of P. florida and P. cornucopiaewere maintained in CSIR-North East Institute of Science &Technology (CSIR-NEIST) Mushroom GermplasmUnit, Jorhat, Assam, India and cultivated in the cultivation unit. A total of 24 treatments were given to eachsample by exposing it to UV rays ranging from UV-A (365nm and 395nm) and UV-B (280nm and 310nm)for different time periods. It was observed that Vitamin D2 levels varied with different wavelengths used.In both the species, Vitamin D2 levels increased in the UV-B range than in the UV-A range. Moreover,between the two species under study, P. florida showed the highest Vitamin D2 accumulation potential at280nm when exposed for 120 minutes. The level of Vitamin D2 increased to an optimum level at 120 minutesof UV exposure and then declined upon the increase in the time period. The recommended daily allowanceof Vitamin D is 400-800 IU/day according to WHO. In this study, post-UV treatment, the Vitamin D2 levelsdrastically increased to a range of 1000-6000 IU approximately which is safe and can be used in thepreparation of Vitamin D supplements in future.

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“…It is believed that structural complexity of polysaccharides contributes to its bioactive potential. Medicinal mushrooms have demonstrated anti-proliferative effects from multiple studies Blagodatski et al, 2018;Shnyreva, Shnyreva, Espinoza, Padrón, & Trigos, 2018;Panda et al, 2020;Souilem et al, 2017;.…”

Section: Introductionmentioning

confidence: 99%

Bioactive polysaccharides and small molecules from the native North American fungus Echinodontium tinctorium

Zeb¹

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Mushrooms, the fruiting bodies of fungi, are known to be powerful sources of nutraceuticals and pharmaceuticals but there are limited studies focusing on exploring the medicinal value of mushrooms native to North America. Here, I describe the isolation of two novel bioactive polysaccharides from the aqueous extracts of the fungus Echinodontium tinctorium: an immunostimulatory complex polysaccharide (EtISPFa) of 1354 kDa, and a growth-inhibitory β-glucan of 275 kDa. In addition, six small molecules including a phenol derivative, a new diphenylmethane derivative and three lanostane-type triterpenes were isolated from the organic extracts of E. tinctorium. The molar mass of these isolated small molecules (labelled 1-6) was determined to be 124, 260, 506, 498, 496, and 440 g/mol respectively.Phase separation, Sephadex LH-20 size exclusion, Sephadex DEAE ion exchange chromatography, Sephacryl S-500 HR size exclusion, silica column chromatography, and HPLC were used for bioactivity-guided purification. Chemical structures and linkages of EtISPFa and EtGIPL1a polysaccharides were determined by gas chromatography mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Final structures of small molecules were determined by Fourier transform infrared spectroscopy (FTIR), electrospray ionization mass spectrometry (ESI-MS), NMR, and X-ray crystallography.Immuno-stimulatory activity of EtISPFa was assessed by immunoassay in Raw 264.7 murine macrophage cells and growth-inhibitory activity of EtGIPL1a and small molecules were assessed by MTT growth-inhibitory assay in cancer cell lines. The mechanism of growth inhibition was assessed via apoptosis and cell cycle assays. EtISPFa stimulated the immune response by inducing TNF-α and other inflammatory cytokines in murine macrophage cells. In contrast, EtGIPL1a showed promising anti-proliferative activity against U251 glioblastoma cells and on iii ten other cancer cell lines. EtGIPL1a induced apoptosis in U251 cells with an increased cleaved caspase-3 apoptotic marker and significant DNA fragmentation in cell cycle analysis. Amongst the small molecules, compounds (2), (4) and (5) caused growth-inhibition in U251 cells; compound (4) also showed promising effects on multiple other cancer cell lines; all its bioactivities are reported here for the first time. The crystal structures of compounds (2), (4) and(5) have also been reported for the first time. Molecular targets of (1), ( 2), (4) and (5) by MolTarPred were predicted and warrants further experimental investigation. iv PREFACE This current PhD dissertation has yielded two manuscripts where Chapter 1 and Chapter 2 have been published as:

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Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions

Cited by 7 publications

References 186 publications

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Study of Vitamin D2 accumulation potential of two edible mushrooms from North-East India

Bioactive polysaccharides and small molecules from the native North American fungus Echinodontium tinctorium

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