Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro

Coşkun, Melis Debreli; Arı, Ferda; Oral, Arzu Yilmaztepe; Sarimahmut, Mehmet; Kutlu, Hatice Mehtap; Yılmaz, Veysel T.; Ulukaya, Engin

doi:10.1016/j.bmc.2013.05.023

Cited by 58 publications

(27 citation statements)

References 32 publications

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“…[137][138][139] Metal-based chemotherapeutic agents and especially platinum complexes are more effective. 141,142 The results suggested a marked improvement in the cytotoxicity of complex 52. 141,142 The results suggested a marked improvement in the cytotoxicity of complex 52.…”

Section: View Article Onlinementioning

confidence: 91%

Anti-cancer palladium complexes: a focus on PdX₂L₂, palladacycles and related complexes

2014

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Much success has been achieved with platinum-based chemotherapeutic agents, i.e. through interactions with DNA. The long-term application of Pt complexes is thwarted by issues, leading scientists to examine other metals such as palladium which could exhibit complementary modes of action (given emphasis wherever known). Over the last 10 years several research groups have focused on the application of an eclectic array of palladium complexes (of the type PdX2L2, palladacycles and related structures) as potential anti-cancer agents. This review therefore provides readers with an up to date account of the advances that have taken place over the past several decades.

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Section: View Article Onlinementioning

confidence: 91%

Anti-cancer palladium complexes: a focus on PdX₂L₂, palladacycles and related complexes

2014

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“…As an example, Pd (II) saccharinate complexes with bis (2-pyridylmethyl) amine induce cell death by apoptosis in human breast cancer cells in vitro [17]. A Pd (II)-saccharinate complex containing terpyridine powerfully inhibits the growth of fibrosarcoma cells by inducing apoptosis [18]. In gastric cancer cells, [PdCl2 (L)] is a potent chemotherapeutic agent for Cisplatin-resistant gastric cancer and may have clinical applications [19].…”

Section: Discussionmentioning

confidence: 99%

Antitumor activity of a Trans-thiosemicarbazone schiff base palladium (II) complex on human gastric adenocarcinoma cells

Zhang

Luo

et al. 2017

Oncotarget

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The development of transition-metal-based antitumor drug candidates increases the metallopharmaceuticals study dramatically. Two trans-thiosemicarbazone-based, Schiff base palladium (Pd) (II) complexes, DMABTSPd (TSPd) and DMABPTSPd (PTSPd), were prepared and characterized as described in our previous study. Here, we investigated whether the two complexes have antitumor effect on human gastric adenocarcinoma cell lines, BGC-823 and SGC-7901, compared with normal human gastric mucosal epithelial cell line, Ges-1. The results show that the Pd complex with the bare amino group (DMABTSPd(TSPd)) can inhibit cell viabilities and induce apoptosis in human gastric carcinoma cells, rather than the Pd complex without the bare amino group (DMABPTSPd (PTSPd)). This occurs via a mitochondrial-related pathway by down-regulating the level of Bcl-2 expression and up-regulating the level of Bid expression. Meanwhile, DMABTSPd (TSPd) suppressed tumor growth via a mitochondrial-related pathway in a nude mouse tumor xenograft model derived from BGC-823 cells. These findings demonstrate that DMABTSPd (TSPd) is worthy of further structural optimization and representing a promising Pd complex for the development of a new antitumor therapeutic agent.

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“…4 Moreover, other recent study of ours with the same complex again, we reported the IC 50 values being as low as 0.64 and 0.57 lM against fibrosarcoma (5RP7 and NIH/3T3 cell lines), respectively. 22 …”

Section: Cytotoxic Activities Of the Pd(ii) Complex By The Mtt And Atmentioning

confidence: 97%

“…[21][22][23][24] Indeed, we found that the Pd(II) complex had a significant anti-growth effect against MCF-7 and MDA-MB-231 human breast cancer cell lines in a dose dependent manner. In a previous study, in which a Pd(II)-derived complex was used against MCF-7 breast cancer cells, it was reported that the IC 50 value was 25.6 lM.…”

Section: Cytotoxic Activities Of the Pd(ii) Complex By The Mtt And Atmentioning

confidence: 99%

Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo

Arı

Cevatemre

Armutak

et al. 2014

Bioorganic & Medicinal Chemistry

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Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro

Cited by 58 publications

References 32 publications

Anti-cancer palladium complexes: a focus on PdX₂L₂, palladacycles and related complexes

Anti-cancer palladium complexes: a focus on PdX₂L₂, palladacycles and related complexes

Antitumor activity of a Trans-thiosemicarbazone schiff base palladium (II) complex on human gastric adenocarcinoma cells

Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo

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Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro

Cited by 58 publications

References 32 publications

Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes

Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes

Antitumor activity of a Trans-thiosemicarbazone schiff base palladium (II) complex on human gastric adenocarcinoma cells

Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo

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Product

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Anti-cancer palladium complexes: a focus on PdX₂L₂, palladacycles and related complexes

Anti-cancer palladium complexes: a focus on PdX₂L₂, palladacycles and related complexes