Promising effects of gingerol against toxins: A review article

Yahyazadeh, Roghayeh; Rahimi, Vafa Baradaran; Yahyazadeh, Ahmad; Mohajeri, Seyed Ahmad; Askari, Vahid Reza

doi:10.1002/biof.1779

Cited by 25 publications

(33 citation statements)

References 212 publications

(186 reference statements)

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“…The ELISA assay evaluated the IL-1 β , IL-6, TNF- α , and PGE2 levels as inflammatory mediators, which were carried out in accordance with the manufacturers' protocol, IBL company [ 6 , 7 , 24 , 26 , 28 ], USA. In summary, 1.5 × 10 6 cells were cultured in a 6-well plate overnight, and they were treated according to the experimental grouping section.…”

Section: Methodsmentioning

confidence: 99%

“…The nitrite oxide metabolite levels were measured based on the measurement of nitrite (NO −2 ) as the stable and the final NO product by the Griess method described elsewhere [ 30 ]. The NO levels were assessed in the supernatant at 540 nm by using the standard curve of different nitrite concentrations [ 6 , 7 , 24 , 26 – 28 ].…”

Section: Methodsmentioning

confidence: 99%

“…Sepsis is a lethal condition caused by an overreaction of the immune system to infection that can lead to tissue damage, multiple organ failure, and even death [ 1 – 4 ]. Myocardial dysfunction is one of the prominent sepsis features that has proved to be associated with a high mortality risk for septic patients [ 5 , 6 ]. Many studies have reported the crucial role of proinflammatory cytokines in myocardial oxidative damage that commonly occurs in the course of sepsis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is consequently necessary to consider efficient therapeutic interventions to prevent sepsis-induced cardiomyopathy. There is growing evidence on natural compounds, especially plants' secondary metabolites, are capable of representing optimal therapeutic effects in alleviating LPS-induced cardiotoxicity [ 6 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Taherzadeh

Rahimi

Amiri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Acetyl-11-keto-beta-boswellic acid (AKBA), the major component of Boswellia serrata, exhibits anti-inflammatory activities. This in vitro study investigated the protective effects of AKBA against lipopolysaccharide (LPS)-induced cardiac dysfunction. In this study, the H9C2 cardiomyocytes were pretreated with AKBA (2.5, 5, and 10 μM for 24 h), and then cotreated with LPS for another 24 h. The MTT assay, ELISA test kits, and quantitative real-time PCR analysis assessed the cell viability, levels of proinflammatory factors (IL-β, IL-6, TNF- α, and PGE2), and the gene expression of IL-β, IL-6, TNF- α, iNOS, and COX-2, respectively. The nitric oxide (NO) and thiol levels were also measured using a biochemical assay. The results indicated that LPS exposure markedly reduced cell viability and total thiol content, but increased the inflammatory cytokines, NO metabolites, and gene expression of proinflammatory mediators in H9C2 cells. AKBA pretreatment significantly altered the mentioned factors induced by LPS. Our results demonstrated that AKBA might be a promising therapeutic agent for treating sepsis-related cardiac dysfunction in the future.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Taherzadeh

Rahimi

Amiri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…(6)-gingerol has also been proven to impede hamster buccal pouch carcinogenesis associated with chemically-induced inflammation and cell proliferation via the modulation of Nrf2 signaling ( Sun et al, 2021 ). Gingerol elicits its protective activity through different mechanisms and cell signaling pathways, of which, MAPK, NF-κB, Wnt/β-catenin, Nrf2/ARE, TGF-β1/Smad3, and ERK/CREB are prominent ( Yahyazadeh et al, 2021 ).…”

Section: Gingerolmentioning

confidence: 99%

Cancer Chemoprevention: A Strategic Approach Using Phytochemicals

Swetha

Keerthana

et al. 2022

Front. Pharmacol.

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Cancer chemoprevention approaches are aimed at preventing, delaying, or suppressing tumor incidence using synthetic or natural bioactive agents. Mechanistically, chemopreventive agents also aid in mitigating cancer development, either by impeding DNA damage or by blocking the division of premalignant cells with DNA damage. Several pre-clinical studies have substantiated the benefits of using various dietary components as chemopreventives in cancer therapy. The incessant rise in the number of cancer cases globally is an issue of major concern. The excessive toxicity and chemoresistance associated with conventional chemotherapies decrease the success rates of the existent chemotherapeutic regimen, which warrants the need for an efficient and safer alternative therapeutic approach. In this scenario, chemopreventive agents have been proven to be successful in protecting the high-risk populations from cancer, which further validates chemoprevention strategy as rational and promising. Clinical studies have shown the effectiveness of this approach in managing cancers of different origins. Phytochemicals, which constitute an appreciable proportion of currently used chemotherapeutic drugs, have been tested for their chemopreventive efficacy. This review primarily aims to highlight the efficacy of phytochemicals, currently being investigated globally as chemopreventives. The clinical relevance of chemoprevention, with special emphasis on the phytochemicals, curcumin, resveratrol, tryptanthrin, kaempferol, gingerol, emodin, quercetin genistein and epigallocatechingallate, which are potential candidates due to their ability to regulate multiple survival pathways without inducing toxicity, forms the crux of this review. The majority of these phytochemicals are polyphenols and flavanoids. We have analyzed how the key molecular targets of these chemopreventives potentially counteract the key drivers of chemoresistance, causing minimum toxicity to the body. An overview of the underlying mechanism of action of these phytochemicals in regulating the key players of cancer progression and tumor suppression is discussed in this review. A summary of the clinical trials on the important phytochemicals that emerge as chemopreventives is also incorporated. We elaborate on the pre-clinical and clinical observations, pharmacokinetics, mechanism of action, and molecular targets of some of these natural products. To summarize, the scope of this review comprises of the current status, limitations, and future directions of cancer chemoprevention, emphasizing the potency of phytochemicals as effective chemopreventives.

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Promising influences of gingerols against metabolic syndrome: A mechanistic review

2022

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Metabolic syndrome is an inflammatory disorder characterized by diabetes, obesity, atherosclerosis, and hypertension. Globally, this disease is increasing, especially in developed countries. Supposedly, herbal treatments for this disease likely have fewer adverse effects than chemical medications. Thus, they can be suitable options among the available chemical treatments. Ginger has been used as a spice and medicinal plant in traditional medicine and cooking. This herbal compound and its derivatives, such as 6‐gingerol, have shown promising effects on various molecular aspects of metabolic syndrome. In this study, we reviewed and discussed the significant impacts of gingerol, a derivative of ginger, on metabolic syndrome through various mechanisms. The benefits of 6‐gingerol include its effects on AMP‐activated protein kinase (AMPK), which prevent diabetes, lipid regulating effect (peroxisome proliferator‐activated receptors, PPARs), as well as its effects on enzymes and proteins preventing hyperlipidemia caused by a high‐fat diet. In addition, 6‐gingerol has anti‐atherosclerosis and anti‐hypertension effects through several molecular mechanisms. The current review will discuss various effects of 6‐gingerol on molecular pathways involved in diabetes, obesity, atherosclerosis, and hypertension as characterizing features of metabolic syndrome and suggests that 6‐gingerol can be a potential treatment agent for metabolic syndrome and shed light on a higher requirement for more pre‐clinical and clinical investigations.

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Promising effects of gingerol against toxins: A review article

Cited by 25 publications

References 212 publications

Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Cancer Chemoprevention: A Strategic Approach Using Phytochemicals

Promising influences of gingerols against metabolic syndrome: A mechanistic review

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