Promising Hydrogels-Based Dressings for Optimal Treatment of Cutaneous Lesions

Abstract

Worldwide, cutaneous lesions care represents a daily challenge for the medical system, with an increasing prevalence from year to year (from ~5 million in 2005 to about 8 million in 2018) and high costs for their treatment (between ~$28 billion and ~$97 billion). Injuries are the most frequent and destructive form of skin damage, affecting patients’ quality of life. To promote wound healing, an ideal treatment involves proper dressings that can manage the local pain, inflammation, or infection. Passive or dry traditional dressings, such as cotton, gauze, or lint, have limited therapeutic actions and demand periodic replacement of the dressing. Therefore, an optimal alternative for advanced wound care is represented by hydrogels, one of the five classes of modern dressings, which assure excellent local moisture, due to their high ability to absorb a large volume of water inside their three-dimensional networks. Moreover, hydrogels possess suitable biocompatibility, biodegradability, porosity, elasticity, flexibility, and biological properties similar to the extracellular matrix. This chapter presents the main characteristics of the hydrogels and the recent research regarding the development of new hydrogel dressings, based on natural, semi-synthetic, or synthetic biopolymers, loaded with varied therapeutic agents to stimulate the tissue regeneration of different etiologies cutaneous lesions.

Chitosan-Based Hydrogel in the Management of Dermal Infections: A Review

“…Furthermore, research and development efforts in crosslinking techniques for hydrogels aim to enhance their mechanical properties, control degradation rates, improve biocompatibility, and explore innovative approaches that minimize the potential toxicity associated with crosslinkers [34]. Reproduced with permission from [35] under CC BY 3.0.…”

“…Gulafshan et al fabricated a PVA-alginate hydrogel for accelerated wound healing [39]. Reproduced with permission from [35] under CC BY 3.0.…”

“…Figure 2. Hydrogels' molecular composition without bioactive (a) and fortified with bioactive (b).Reproduced with permission from[35] under CC BY 3.0.…”