Promising Immunomodulatory Effects of Selected Strains of Dairy Propionibacteria as Evidenced In Vitro and In Vivo

Abstract

Immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (PBMCs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (IL-10). Two selected strains of Propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria.

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

“…Other dairy P. freudenreichii strains also showed promising immunomodulatory properties by strongly inducing the synthesis of anti-inflammatory IL-10 by human PBMCs and could be helpful in the treatment of inflammatory conditions or diseases [171].…”

“…It has been demonstrated that consumption of either isolated BGS or P. freudenreichii strains ameliorate experimental colitis in mice and human ulcerative colitis [171,[189][190][191][192]. The mechanism proposed for this effect was restoring of microbiota intestinal balance and suppressing inflammatory lymphocyte infiltration.…”

“…The mechanism proposed for this effect was restoring of microbiota intestinal balance and suppressing inflammatory lymphocyte infiltration. In this respect, it has been proposed that some surface compounds should be involved in immunomodulatory effects of propionibacteria since removal of surface layer proteins decreased the in vitro induction of anti-inflammatory cytokines [171]. By their side, Michel et al [193] demonstrated that colonic infusion with P. acidipropionici reduced the severity of TNBS induced colitis in rats whereas Kajander et al [194] reported that the multispecies probiotic mixture containing…”

Probiotics in Dairy Fermented Products

“…lactis (Santos-Rocha et al, 2012), as well as Lactobacillus helveticus (Guglielmetti et al, 2010). Modulation of colon cancer cell growth was also reported in vitro and/or in animal models for P. freudenreichii (Cousin et al, 2010;Lan et al, 2008), when the cells were exposed to yogurt containing S. thermophilus and L. bulgaricus (Narushima et al, 2010;Perdigon et al, 2002) and L. helveticus (de Moreno et al, 2010). Future trends may thus include the development of specific fermented dairy products designed for specific population.…”

“…For example, immunomodulatory anti-inflammatory properties were described in certain strains of Propionibacterium freudenreichii (Foligné et al, 2010;Deutsch et al, 2012), Streptococcus thermophilus (Ogita et al, 2011), Lactobacillus delbrueckii subsp. bulgaricus and subsp.…”