Promising influences of zingerone against natural and chemical toxins: A comprehensive and mechanistic review

Shamsabadi, Shahnam; Nazer, Yazdan; Ghasemi, Javad; Mahzoon, Erfan; Baradaran Rahimi, Vafa; Ajiboye, Basiru O.; Askari, Vahid Reza

doi:10.1016/j.toxicon.2023.107247

Cited by 12 publications

(4 citation statements)

References 92 publications

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“…Medicinal plants are widely recognized as safe treatment options, providing protective efects against a broad spectrum of toxic agents, whether natural or synthetic [20,21]. Tese agents not only neutralize the negative efects of toxicants [22] but also play a crucial role in adjusting immunity-related genes, thereby boosting the body's defense against infections and infestations [23, 24] Among these, P. granatum has garnered extensive attention due to its constituents' involvement in various biological and pharmacological activities, contributing to overall health benefts [25].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Punica granatum and Isolated Compounds: Evidence-Based Advances to Treat Bacterial Infections

Mendes,

Gomes Fontoura,

Rodrigues

et al. 2023

International Journal of Microbiology

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Punica granatum Linn has been known for its nutritional and medicinal value since ancient times and is used in the treatment of various pathologies owing to its antibacterial properties. This review reports the results of the most recent studies on the antibacterial effects of P. granatum and its isolated compounds on bacteria of clinical interest. A search in the PubMed, Scopus, Science Direct, and Science Citation Index Expanded (Web of Science) databases was performed, which included articles that evaluated the antibacterial activity of P. granatum extracts and excluded articles that analyzed other microorganisms or nonpathogenic bacteria, as well as theses, dissertations, duplicate articles, and those not fully available. The literature suggests that P. granatum extracts can act on bacteria, such as methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Streptococcus mutans, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. In addition, fruit peel was the most commonly used pharmacogen and methanol, ethanol, and water were the most common solvents for the extraction of bioactive compounds. The antibacterial potential of the methanolic extract of pomegranate peel could be attributed to the presence of active compounds, such as 5-hydroxymethylfurfural, punicic acid, gallic acid, and punicalagin. Thus, there is evidence that these plant extracts, having high polyphenol content, can disrupt the bacterial plasma membrane and inhibit the action of proteins related to antimicrobial resistance. P. granatum shows antibacterial activity against Gram-positive and Gram-negative bacteria, with great potential against multidrug-resistant strains. Further research is needed to clarify the mechanism of action related to this biological activity and investigate the isolated substances that may be responsible for the antibacterial effects.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Punica granatum and Isolated Compounds: Evidence-Based Advances to Treat Bacterial Infections

Mendes,

Gomes Fontoura,

Rodrigues

et al. 2023

International Journal of Microbiology

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“…There are countries where cuisines and beverages widely use various herbs and spices. Many of the phytochemicals included in these cuisines possess anti-inflammatory and antioxidant effects (for example zingerone of ginger [27,28] and curcumin of turmeric [28,29]), and some may bind to the SARS-CoV-2 that causes COVID-19 as well (for example carvacrol in oregano and thyme [17,30], cinnamaldehyde in cinnamon [30], geraniol in lemongrass, lavender, rose and others [30], curcumin in turmeric [30][31][32] and others [33]). It is possible that depending on the traditional cuisines in each country, there are differences in the type and amount of these phytochemicals consumed, and that may have produced the differences in the infection, severity, and recovery from COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Koyama,

Shields,

Heinbockel

et al. 2024

Preprint

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PurposeThere have been large geographical differences in the infection and death rates of COVID-19. Foods and beverages containing high amounts of phytochemicals with bioactive properties were suggested to prevent contracting, to limit the severity of, and to facilitate recovery from COVID-19. The goal of our study was to determine the correlation of the type of foods/beverages people consumed and the risk reduction of contracting COVID-19 and the recovery from COVID-19.MethodsWe developed an online survey that asked the participants whether they contracted COVID-19, their symptoms, time to recover, and their frequency of eating various types of foods/beverages. The survey was first developed in English and then translated into 10 different languages.ResultsThe participants who did not contract COVID-19 consumed vegetables, herbs/spices, and fermented foods/beverages significantly more than the participants who contracted COVID-19 and those who were not tested but became sick most likely from COVID-19. The geographic location of participants corresponded with the language of the survey, except for the English version, thus, nine out of the 10 language versions represented a country. Among the six countries (India, Iran, Italy, Japan, Russia, Spain) with over one hundred participants, we found that in India and Japan the people who contracted COVID-19 showed significantly shorter recovery time, and greater daily intake of vegetables, herbs/spices, and fermented foods/beverages was associated with faster recovery.ConclusionOur results suggest that phytochemical compounds included in the vegetables may have contributed in not only preventing contraction of COVID-19, but also accelerating their recovery. (249 words; EJN limit is 250 words)

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“…It is used in the food industry as a flavoring agent ( 11 ). Zingerone has different health medicinal benefits, including antibacterial and anti-biofilm ( 12 ). In this study, to enhance the antibacterial and antibiofilm activities of zingeron, zingeron loaded niosomes were synthetized.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antibiofilm activities of zingerone and niosomal zingerone against methicillin-resistant Staphylococcus aureus (MRSA)s

Larijanian,

Shafiei,

Pirbalouti

et al. 2024

IJM

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Background and Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial and community acquired infections. Nanoparticles are considered as proper tools to overcome the therapeutic problem of anti- microbial-resistant infections because of the drug concentration increment at the desired location and protection from enzy- matic degradation. The goal of this study was to evaluate the effect of the antibacterial and antibiofilm activities of zingerone and niosome containing zingerone against pre-formed biofilm of MRSA isolates. Materials and Methods: 62 MRSA isolates cultured from patients with diabetic ulcers were investigated. Niosomes were synthesized and characterized by X- ray diffraction, zeta potential and scanning electron microscopy (SEM). The size of niosomal particles measured by SEM and zetasizer. Results: The surface charge of prepared niosomes was about -37 mV. The effect of the zingerone and noisome containing zingerone was evaluated against biofilms of MRSA isolates. Also, the antibiofilm activity of prepared niosomes on gene expression of MRSA biofilms was evaluated using Real Time PCR. Our results demonstrated that the niosome containing zingerone had a diameter of 196.1 nm and a -37.3-mV zeta potential. Zingerone removed one and three-day old biofilms of MRSA at the concentration of 1000 µg/ml, while the zingerone-laoded niosomes removed 1, 3- and 5-days old biofilms at the concentration of 250 µg/ml, 250 µg/ml, and 500 µg/ml. Conclusion: The results indicated that niosome containing zingerone eliminated MRSA and its biofilms faster compared with free zingerone and it suggested that zingerone-encapsulated niosomes could be considered as a promising treatment against MRSA and its biofilms.

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Promising influences of zingerone against natural and chemical toxins: A comprehensive and mechanistic review

Cited by 12 publications

References 92 publications

Therapeutic Potential of Punica granatum and Isolated Compounds: Evidence-Based Advances to Treat Bacterial Infections

Therapeutic Potential of Punica granatum and Isolated Compounds: Evidence-Based Advances to Treat Bacterial Infections

Possible roles of phytochemicals with bioactive properties in the prevention of and recovery from COVID-19

Antibacterial and antibiofilm activities of zingerone and niosomal zingerone against methicillin-resistant Staphylococcus aureus (MRSA)s

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