Promising New <sup>18</sup>F-Labeled Tracers for PET Myocardial Perfusion Imaging

Brunken, Richard C.

doi:10.2967/jnumed.115.161661

Cited by 12 publications

(13 citation statements)

References 9 publications

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“…Lower HU densities in these segments have previously been documented in MPI studies (Burrell & MacDonald, 2006;Dvorak et al, 2011;Brunken, 2015). The lowest values were detected in the inferoseptal segments.…”

Section: Figuresupporting

confidence: 64%

“…The lowest values were detected in the inferoseptal segments. Lower HU densities in these segments have previously been documented in MPI studies (Burrell & MacDonald, 2006;Dvorak et al, 2011;Brunken, 2015). Studies investigating the diagnostic accuracy of TPR have reported a threshold <0.99 to be sensitive for detection of myocardial ischaemia due to haemodynamically significant stenosis (George et al, 2009;Ko et al, 2012).…”

Section: Figurementioning

confidence: 77%

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Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

Bechsgaard

Gustafsson

Linde

et al. 2018

Clin Physio Funct Imaging

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CT perfusion; myocardial perfusion reserve; non-invasive imaging; reference population; stress testing; transmural perfusion ratio Purpose Combined coronary CT angiography and CT perfusion (CTP) is a novel, non-invasive, 'one-stop' diagnostic tool to rule out ischaemia in patients suspected for coronary artery disease (CAD). However, the normal myocardial perfusion pattern by static CTP in humans is poorly described. We aimed to investigate global and regional myocardial perfusion during rest and adenosine-induced hyperaemia in asymptomatic women without history of coronary heart disease (CHD). Methods Using a 320-row CT scanner with a static protocol, semi-quantitative assessment of rest and stress CTP was performed in 34 asymptomatic middle-aged women without obstructive CAD (<50% stenosis) or history of CHD, and with normal exercise stress test and left ventricular (LV) function. Using a 16-segment model, we assessed global and regional values of LV myocardial perfusion reserve (MPR) and transmural perfusion ratio (TPR). Results MeanAESD age was 56 AE 13 years. Resting and hyperaemic myocardial perfusion was heterogeneously distributed throughout the LV myocardium. During hyperaemia, global MPR increased by median (IQR) 158% (144-176) with the highest increase in the right coronary artery territory (171%; P<0.02). Rest and stress segmental TPR values ranged between 0.93-1.26 and 0.99-1.13, respectively, with the lowest values detected in the inferoseptal segments. No differences in perfusion parameters were found between participants with normal epicardial arteries and participants with non-significant epicardial atheromatosis (all P>0.05). Global perfusion parameters were not associated with age or menopausal status (all P>0.05). Conclusions This descriptive study presents data on global and regional myocardial perfusion in a cohort of healthy middle-aged women.CT assessed myocardial perfusion in healthy women, D. F. Bechsgaard et al. Figure 9Bland-Altman plot of interobserver variability for (a) attenuation density during rest; (b) attenuation density during hyperemia; (c) transmural perfusion ratio during rest; and (d) transmural perfusion ratio during hyperemia.

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Section: Figuresupporting

confidence: 64%

Section: Figurementioning

confidence: 77%

Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

Bechsgaard

Gustafsson

Linde

et al. 2018

Clin Physio Funct Imaging

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“…1; Suppl. Figure 1) [13–15]. It was also shown that 18 F-FPTP has greater first-pass myocardial extraction than 13 N-ammonia in isolated perfused rat heart, indicating the suitability of 18 F-FPTP as a quantitative myocardial PET imaging agent [14, 15].…”

Section: Introductionmentioning

confidence: 99%

“…Figure 1) [13–15]. It was also shown that 18 F-FPTP has greater first-pass myocardial extraction than 13 N-ammonia in isolated perfused rat heart, indicating the suitability of 18 F-FPTP as a quantitative myocardial PET imaging agent [14, 15]. In addition, no metabolite was detected in the serum of mice 30 min after intravenous injection of 18 F-FPTP, implying that the metabolite correction would not be necessary in the kinetic analysis of 18 F-FPTP myocardial PET data [13].…”

Section: Introductionmentioning

confidence: 99%

“…There was also a strong correlation between myocardial defect size measured by 18 F-FPTP PET and the hypoperfused area measured by quantitative 2,3,5-triphenyltetrazolium chloride staining in a rat myocardial infarction (MI) model [16]. Rapid washout from the liver is another merit of 18 F-FPTP, which is advantageous during the evaluation of lateral myocardial wall uptake [2, 5, 15, 16].

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Section: Introductionmentioning

confidence: 99%

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Comparative evaluation of the algorithms for parametric mapping of the novel myocardial PET imaging agent 18F-FPTP

et al. 2017

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Objective(18F-fluoropentyl)triphenylphosphonium salt (18F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of 18F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken.Methods 18F-FPTP dynamic PET (18 min) and CT images were acquired from rats with myocardial infarction (MI) (n = 12). Regions of interest (ROIs) were on the left ventricle, normal myocardium, and MI region. Two-compartment (K 1 and k 2; 2C2P) and three-compartment (K 1–k 3; 3C3P) models with irreversible uptake were compared for goodness-of-fit. Partial volume and spillover correction terms (V a and α = 1 − V a) were also incorporated. LLS and BFM were applied to ROI- and voxel-based kinetic parameter estimations. Results were compared with the standard ROI-based nonlinear least-squares (NLS) results of the corresponding compartment model. A simulation explored statistical properties of the estimation methods.ResultsThe 2C2P model was most suitable for describing 18F-FPTP kinetics. Average K 1, k 2, and V a values were, respectively, 6.8 (ml/min/g), 1.1 (min−1), and 0.44 in normal myocardium and 1.4 (ml/min/g), 1.1 (min−1), and 0.32, in MI tissue. Ten minutes of data was sufficient for the estimation. LLS and BFM estimations correlated well with NLS values for the ROI level (K 1: y = 1.06x + 0.13, r 2 = 0.96 and y = 1.13x + 0.08, r 2 = 0.97) and voxel level (K 1: y = 1.22x − 0.30, r 2 = 0.90 and y = 1.26x + 0.00, r 2 = 0.92). Regional distribution of kinetic parametric images (αK 1, K 1, k 2, V a) was physiologically relevant. LLS and BFM showed more robust characteristics than NLS in the simulation.ConclusionsFast kinetics and highly specific uptake of 18F-FPTP by myocardium enabled quantitative analysis with the 2C2P model using only the initial 10 min of data. LLS and BFM were feasible for estimating voxel-wise parameters. These two methods will be useful for quantitative evaluation of 18F-FPTP distribution in myocardium and in further studies with different conditions, disease models, and species.Electronic supplementary materialThe online version of this article (doi:10.1007/s12149-017-1171-6) contains supplementary material, which is available to authorized users.

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Synthesis and Evaluation of [¹⁸F]‐Ammonium BODIPY Dyes as Potential Positron Emission Tomography Agents for Myocardial Perfusion Imaging

Chansaenpak

Wang

et al. 2016

Chemistry A European J

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Recently, we demonstrated the potential of a [(18) F]-trimethylammonium BODIPY dye for cardiac imaging. This is the first example of the use of the [(18) F]-ammonium BODIPY dye for positron emission tomography (PET) myocardial perfusion imaging (MPI). In this report, we extend our study to other ammonium BODIPY dyes with different nitrogen substituents. These novel ammonium BODIPY dyes were successfully prepared and radiolabeled by the SnCl4 -assisted (18) F-(19) F isotopic exchange method. The microPET results and the biodistribution data reveal that nitrogen substituent changes have a significant effect on the in vivo and pharmacological properties of the tracers. Of the novel [(18) F]-ammonium BODIPY dyes prepared in this work, the [(18) F]-dimethylethylammonium BODIPY is superior in terms of myocardium uptake and PET imaging contrast. These results support our hypothesis that the ammonium BODIPY dyes have a great potential for use as PET/optical dual-modality MPI probes.

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Promising New ¹⁸F-Labeled Tracers for PET Myocardial Perfusion Imaging

Cited by 12 publications

References 9 publications

Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

Comparative evaluation of the algorithms for parametric mapping of the novel myocardial PET imaging agent 18F-FPTP

Synthesis and Evaluation of [¹⁸F]‐Ammonium BODIPY Dyes as Potential Positron Emission Tomography Agents for Myocardial Perfusion Imaging

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Promising New 18F-Labeled Tracers for PET Myocardial Perfusion Imaging

Cited by 12 publications

References 9 publications

Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

Comparative evaluation of the algorithms for parametric mapping of the novel myocardial PET imaging agent 18F-FPTP

Synthesis and Evaluation of [18F]‐Ammonium BODIPY Dyes as Potential Positron Emission Tomography Agents for Myocardial Perfusion Imaging

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About

Promising New ¹⁸F-Labeled Tracers for PET Myocardial Perfusion Imaging

Synthesis and Evaluation of [¹⁸F]‐Ammonium BODIPY Dyes as Potential Positron Emission Tomography Agents for Myocardial Perfusion Imaging