Promising role of temelimab in multiple sclerosis treatment

Irfan, Shayan Ali; Murtaza, Minha; Ahmed, Ali; Altaf, Hina; Ali, Abid A; Shabbir, Naqiha; Baig, Mirza Mehmood Ali

doi:10.1016/j.msard.2022.103743

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…In fact, Natalizumab, one of the main therapeutic strategies for MS patients, was able to reduce the levels of HERV-W expression and also the humoral response against HERV-W peptides after a few months of treatment ( 118 , 119 ). Additionally, a monoclonal antibody against the HERV-W env protein was developed and shown to be safe for use in MS patients ( 120 – 124 ). Although the monoclonal antibody failed to reduce the acute inflammatory response, it was able prevent the neurodegenerative signs ( 125 ).…”

Section: Hervs Expression In Diseasesmentioning

confidence: 99%

Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Rangel

Silva

et al. 2022

Front. Immunol.

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Human Endogenous Retroviruses (HERVs) are derived from ancient exogenous retroviral infections that have infected our ancestors’ germline cells, underwent endogenization process, and were passed throughout the generations by retrotransposition and hereditary transmission. HERVs comprise 8% of the human genome and are critical for several physiological activities. Yet, HERVs reactivation is involved in pathological process as cancer and autoimmune diseases. In this review, we summarize the multiple aspects of HERVs’ role within the human genome, as well as virological and molecular aspects, and their fusogenic property. We also discuss possibilities of how the HERVs are possibly transactivated and participate in modulating the inflammatory response in health conditions. An update on their role in several autoimmune, inflammatory, and aging-related diseases is also presented.

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Section: Hervs Expression In Diseasesmentioning

confidence: 99%

Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Rangel

Silva

et al. 2022

Front. Immunol.

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“…Expression of HERV-related genetic information and its involvement in human pathological processes are mostly unknown and under active investigation. There are numerous publications describing HERV activation in different types of cancer (addressed in this review), as well as in other diseases such as type 1 diabetes ( Levet et al., 2017 ), neurological diseases such as multiple sclerosis (MS) ( Perron et al., 2012a ; Madeira et al., 2016 ; Hartung et al., 2022 ; Irfan et al., 2022 ) and amyotrophic lateral sclerosis (ALS) ( Douville et al., 2011 ; Alfahad and Nath, 2013 ; Arru et al., 2021 ; Phan et al., 2021 ), and psychiatric diseases such as schizophrenia ( Aftab et al., 2016 ; Perron et al, 2012b ; Tamouza et al., 2021 ) and bipolar disorder ( Perron et al., 2012b ; Tamouza et al., 2021 ). Over the last few years, research in this field has led to growing interest in exploring HERV-originated products as biomarkers for disease and specific HERV-derived antigens as targets for immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic regulation of HERV activation in tumors and implications for translational research in oncology

Cherkasova,

Chen,

Childs

2024

Front. Cell. Infect. Microbiol.

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Transcription of distinct loci of human endogenous retroviruses (HERVs) and in some cases, translation of these transcripts have been consistently observed in many types of cancer. It is still debated whether HERV activation serves as a trigger for carcinogenesis or rather occurs as a consequence of epigenetic alterations and other molecular sequelae that characterize cellular transformation. Here we review the known molecular and epigenetic mechanisms of HERV activation in cancer cells as well as its potential contribution to carcinogenesis. Further, we describe the use of HERV expression in cancer diagnostic and characterize the potential of HERV-derived antigens to serve as novel targets for cancer immunotherapy. We believe this review, which summarizes both what is known as well as unknown in this rapidly developing field, will boost interest in research on the therapeutic potential of targeting HERV elements in tumors and the impact of HERV activation in oncogenesis.

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Prognostic significance of neurofilament light in Fingolimod therapy for Multiple Sclerosis: A systemic review and meta-analysis based on randomized control trials

Ashkar

Baig

Arif

et al. 2023

Multiple Sclerosis and Related Disorders

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Promising role of temelimab in multiple sclerosis treatment

Cited by 4 publications

References 26 publications

Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Mechanistic regulation of HERV activation in tumors and implications for translational research in oncology

Prognostic significance of neurofilament light in Fingolimod therapy for Multiple Sclerosis: A systemic review and meta-analysis based on randomized control trials

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