Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management

Abstract

Psoriasis is a chronic inflammatory autoimmune disorder that moderately affects social and interpersonal relationships. Conventional treatments for psoriasis have certain problems, such as poor drug penetration through the skin, hyper-pigmentation, and a burning sensation on normal and diseased skin. Colloidal drug delivery systems overcome the pitfalls of conventional approaches for psoriasis therapeutics and have improved patient safety parameters, compliance, and superior effectiveness. They also entail reduced toxicity. This comprehensive review’s topics include the pathogenesis of psoriasis, causes and types of psoriasis, conventional treatment alternatives for psoriasis, the need for colloidal drug delivery systems, and recent studies in colloidal drug delivery systems for the treatment of psoriasis. This review briefly describes colloidal drug delivery approaches, such as emulsion systems—i.e., multiple emulsion, microemulsion, and nano-emulsion; vesicular systems—i.e., liposomes, ethosomes, noisomes, and transferosomes; and particulate systems—i.e., solid lipid nanoparticles, solid lipid microparticles, nano-structured lipid carriers, dendrimers, nanocrystals, polymeric nanoparticles, and gold nanoparticles. The review was compiled through an extensive search of the literature through the PubMed, Google Scholar, and ScienceDirect databases. A survey of literature revealed seven formulations based upon emulsion systems, six vesicular drug delivery systems, and fourteen particulate systems reported for antipsoriatic drugs. Based on the literature studies of colloidal approaches for psoriasis management carried out in recent years, it has been concluded that colloidal pharmaceutical formulations could be investigated broadly and have a broad scope for effective management of many skin disorders in the coming decades.

Topically Applied Therapies for the Treatment of Skin Disease: Past, Present, and Future

“…The use of multiple emulsions is somewhat limited as they can be complex to formulate and physically unstable. However, they can present an attractive option where incompatible drugs are required to be administered from the same vehicle, and to prolong drug release from the vehicle without increasing trans-dermal permeation (Laugel et al, 1998;Raynal et al, 1993;Singh et al, 2021).…”

Polymeric Nanoparticles as Tunable Nanocarriers for Targeted Delivery of Drugs to Skin Tissues for Treatment of Topical Skin Diseases

“…AMPs comprise LL37, S100 proteins, and β-defensins. As a result, pro-inflammatory mediators such as interleukins (ILs), interferons (IFNs), and tumor necrosis factor-α (TNF-α) are released and activate TH-1 and TH-7 T-lymphocytes, which ultimately triggers an adaptive immune response and keratinocytes proliferation in the epidermis [ 60 , 61 ].…”

Molecular Analysis, Pathophysiology, and Drug Delivery Mechanism with Reference to Psoriasis: A Review

“…The matrix based nanospheres, shell based nano capsules highly branched dendrimers, and the gel emulsifiers are different form PNPs. Enhanced circulation in the body, longer adherence, reduced side effects, non-allergic formulations, biocompatibility, bioavailabilty and biodegradability properties makes them suitable for topical application [53][54][55] .…”