Promising strategy for improving calycosin-7-O-β-D-glucoside production in Astragalus membranaceus adventitious root cultures

Jin, Heyan; Yu, Yang; Quan, Xueli; Wu, Songquan

doi:10.1016/j.indcrop.2019.111792

Cited by 11 publications

(3 citation statements)

References 44 publications

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“…The culture treated with hydrogen peroxide and L-phenylalanine was 8.6 times higher than that treated with hydrogen peroxide alone [37] Astragalus adventitious roots Calycosin isoflavone glycoside Drought stress, methyl jasmonate, and L-phenylalanine…”

Section: Astragalus Adventitious Roots Calycosin Isoflavone Glycosidementioning

confidence: 98%

Advances in Biotechnological Production and Metabolic Regulation of Astragalus membranaceus

Xuan

Zhang

et al. 2023

Plants

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Legume medicinal plants Astragalus membranaceus are widely used in the world and have very important economic value, ecological value, medicinal value, and ornamental value. The bioengineering technology of medicinal plants is used in the protection of endangered species, the rapid propagation of important resources, detoxification, and the improvement of degraded germplasm. Using bioengineering technology can effectively increase the content of secondary metabolites in A. membranaceus and improve the probability of solving the problem of medicinal plant resource shortage. In this review, we focused on biotechnological research into A. membranaceus, such as the latest advances in tissue culture, including callus, adventitious roots, hairy roots, suspension cells, etc., the metabolic regulation of chemical compounds in A. membranaceus, and the research progress on the synthetic biology of astragalosides, including the biosynthesis pathway of astragalosides, microbial transformation of astragalosides, and metabolic engineering of astragalosides. The review also looks forward to the new development trend of medicinal plant biotechnology, hoping to provide a broader development prospect for the in-depth study of medicinal plants.

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Section: Astragalus Adventitious Roots Calycosin Isoflavone Glycosidementioning

confidence: 98%

Advances in Biotechnological Production and Metabolic Regulation of Astragalus membranaceus

Xuan

Zhang

et al. 2023

Plants

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“…En plantas se ha estudiado a fondo la participación de las EROs en la inducción del metabolismo secundario, tal es el caso del fármaco CG (Calicosina-7-O-β-D-glucósido) producido por la planta medicinal Astragalus membranaceus (ampliamente utilizada en la medicina tradicional herbal China), el cual tiene diferentes efectos terapéuticos como antinflamatorio, antioxidante, antitumoral, entre otros; en donde, la estimulación con H2O2 en el medio de cultivo aumentó la producción de este fármaco [8].…”

Section: Beneficios De Las Ero´s En La Producción De Fármacosunclassified

El doble papel de las especies reactivas de oxígeno en el metabolismo celular

Bibián-León

2022

Mexican Journal of Technology and Engineering

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Las reacciones bioquímicas celulares producen moléculas altamente reactivas e inestables denominadas Especies Reactivas de Oxígeno. Estas moléculas continuamente causan daños que, de no controlarse, llevan a muerte celular. Sin embargo, cuando la concentración de las Especies Reactivas de Oxígeno se mantiene en niveles bajos o fisiológicos, fungen como moléculas señalizadoras en procesos metabólicos como lo es la producción de metabolitos secundarios. Estos metabolitos son de interés ya que muchos de ellos tienen efectos farmacológicos y toxicológicos sobre el ser humano. Por ello, dependiendo de la concentración de las Especies Reactivas de Oxígeno dentro de la célula, éstas tienen una doble función en su metabolismo.

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“…In particular, the demand for A. membranaceus is rapidly growing in the pharmaceutical, nutraceutical, food and cosmetics industries. Nevertheless, with the recklessly extensive excavation of medicinal resources, wild A. membranaceus has become an endangered species [ 17 ]. Therefore, we have to comprehensively understand the biosynthetic pathways and corresponding key genes involved in flavonoids’, triterpene saponins’ and polysaccharides’ biosynthesis in A. membranaceus , which have provided great guidance for the medicinal plant breeding and novelty drug exploration derived from A. membranaceus .…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from Astragalus membranaceus

Dong

Yang

et al. 2023

Molecules

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Astragalus membranaceus (A. membranaceus), a well-known traditional herbal medicine, has been widely used in ailments for more than 2000 years. The main bioactive compounds including flavonoids, triterpene saponins and polysaccharides obtained from A. membranaceus have shown a wide range of biological activities and pharmacological effects. These bioactive compounds have a significant role in protecting the liver, immunomodulation, anticancer, antidiabetic, antiviral, antiinflammatory, antioxidant and anti-cardiovascular activities. The flavonoids are initially synthesized through the phenylpropanoid pathway, followed by catalysis with corresponding enzymes, while the triterpenoid saponins, especially astragalosides, are synthesized through the universal upstream pathways of mevalonate (MVA) and methylerythritol phosphate (MEP), and the downstream pathway of triterpenoid skeleton formation and modification. Moreover, the Astragalus polysaccharide (APS) possesses multiple pharmacological activities. In this review, we comprehensively discussed the biosynthesis pathway of flavonoids and triterpenoid saponins, and the structural features of polysaccharides in A. membranaceus. We further systematically summarized the pharmacological effects of bioactive ingredients in A. membranaceus, which laid the foundation for the development of clinical candidate agents. Finally, we proposed potential strategies of heterologous biosynthesis to improve the industrialized production and sustainable supply of natural products with pharmacological activities from A. membranaceus, thereby providing an important guide for their future development trend.

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Promising strategy for improving calycosin-7-O-β-D-glucoside production in Astragalus membranaceus adventitious root cultures

Cited by 11 publications

References 44 publications

Advances in Biotechnological Production and Metabolic Regulation of Astragalus membranaceus

Advances in Biotechnological Production and Metabolic Regulation of Astragalus membranaceus

El doble papel de las especies reactivas de oxígeno en el metabolismo celular

Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from Astragalus membranaceus

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