Promising Technologies in the Field of Helminth Vaccines

Perera, Dilhan J.; Ndao, Momar

doi:10.3389/fimmu.2021.711650

Cited by 26 publications

(15 citation statements)

References 223 publications

(212 reference statements)

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“…Other than RTS,S, there are no licensed vaccines for parasitic diseases. However, there has been progress towards vaccines against both protozoan (reviewed in [ 26 , 27 ]) and helminthic (reviewed in [ 28 , 29 ]) parasites. Additionally, there are multiple vaccines against zoonotic parasites licensed for animals (e.g., Leishmania and Toxoplasma ), suggesting that human anti-parasite vaccines may be a reality in the near future [ 26 ].…”

Section: Parasite Vaccinesmentioning

confidence: 99%

Recent Advances in the Development of Adenovirus-Vectored Vaccines for Parasitic Infections

2023

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Vaccines against parasites have lagged centuries behind those against viral and bacterial infections, despite the devastating morbidity and widespread effects of parasitic diseases across the globe. One of the greatest hurdles to parasite vaccine development has been the lack of vaccine strategies able to elicit the complex and multifaceted immune responses needed to abrogate parasitic persistence. Viral vectors, especially adenovirus (AdV) vectors, have emerged as a potential solution for complex disease targets, including HIV, tuberculosis, and parasitic diseases, to name a few. AdVs are highly immunogenic and are uniquely able to drive CD8+ T cell responses, which are known to be correlates of immunity in infections with most protozoan and some helminthic parasites. This review presents recent developments in AdV-vectored vaccines targeting five major human parasitic diseases: malaria, Chagas disease, schistosomiasis, leishmaniasis, and toxoplasmosis. Many AdV-vectored vaccines have been developed for these diseases, utilizing a wide variety of vectors, antigens, and modes of delivery. AdV-vectored vaccines are a promising approach for the historically challenging target of human parasitic diseases.

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Section: Parasite Vaccinesmentioning

confidence: 99%

Recent Advances in the Development of Adenovirus-Vectored Vaccines for Parasitic Infections

2023

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“…This offers a cost-effective and safe approach to pathogen control, and in the case of veterinary products, does not leave chemical residues in food. Despite stunning successes in the development of vaccines against viral and bacterial infections, vaccines against most helminth species have yet to be developed commercially (for recent reviews see Claerebout and Geldhof, 2020; McManus, 2020; Perera and Ndao, 2021). The reasons for this are varied but one major obstacle in the way is the ability of helminths to modulate the host immune system such that vaccines cannot elicit sufficient responses for protection (Dalton et al ., 2013).…”

Section: Dealing With Outbreaks Of Diseasementioning

confidence: 99%

Foodborne trematodes: old foes, new kids on the block and research perspectives for control and understanding host–parasite interactions

Robinson

Sotillo

2022

Parasitology

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Foodborne trematodes (FBTs) have a worldwide distribution (with particular prevalence in south-east Asia) and are believed to infect almost 75 million people, with millions more living at risk of infection. Although mortality due to trematodiasis is low, these infections cause considerable morbidity and some species are associated with the development of cancer in hyperendemic regions. Despite this, FBTs are often side-lined in terms of research funding and have been dubbed neglected tropical diseases by the World Health Organisation. Thus, the aim of this special issue was to provide an update of our understanding of FBT infections, to shine a light on current work in the field and to highlight some research priorities for the future. With contributions from leading researchers, many from endemic regions, we review the major FBT species. In doing so we revisit some old foes, uncover emerging infections and discover how outbreaks are being dealt with as a result of new approaches to parasite control. We also report advances in our understanding of the interactions of FBTs with their mammalian hosts and uncover new interplay between trematodes and host microbiome components. We hope that this article collection will stimulate discussion and further research on the FBTs and help raise them from their neglected status.

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“…Helminths are a wide variety of multicellular invertebrates with complex life cycles; among them, over 280 species can infect humans [ 25 ]. The main helminth species that cause human diseases include Ascaris lumbricoides , Hookworm, Whipworm, Schistosoma , etc.…”

Section: Effects Of Helminth Infections On Vaccine Efficacymentioning

confidence: 99%

A New Role for Old Friends: Effects of Helminth Infections on Vaccine Efficacy

Zhu¹,

Liu²,

Liu³

et al. 2022

Pathogens

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Vaccines are one of the most successful medical inventions to enable the eradication or control of common and fatal diseases. Environmental exposure of hosts, including helminth infections, plays an important role in immune responses to vaccines. Given that helminth infections are among the most common infectious diseases in the world, evaluating vaccine efficiency in helminth-infected populations may provide critical information for selecting optimal vaccination programs. Here, we reviewed the effects of helminth infections on vaccination and its underlying immunological mechanisms, based on findings from human studies and animal models. Moreover, the potential influence of helminth infections on SARS-CoV-2 vaccine was also discussed. Based on these findings, there is an urgent need for anthelmintic treatments to eliminate helminth suppressive impacts on vaccination effectiveness during implementing mass vaccination in parasite endemic areas.

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Promising Technologies in the Field of Helminth Vaccines

Cited by 26 publications

References 223 publications

Recent Advances in the Development of Adenovirus-Vectored Vaccines for Parasitic Infections

Recent Advances in the Development of Adenovirus-Vectored Vaccines for Parasitic Infections

Foodborne trematodes: old foes, new kids on the block and research perspectives for control and understanding host–parasite interactions

A New Role for Old Friends: Effects of Helminth Infections on Vaccine Efficacy

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