Promisomics and the Short-Circuiting of Mind

Gomez‐Marin, Alex

doi:10.1523/eneuro.0521-20.2021

Cited by 11 publications

(5 citation statements)

References 55 publications

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“…There have been numerous critiques of such approaches in understanding network computation (Bargmann and Marder 2013;Gomez-Marin 2021). Our analysis bridges such structural observations of connectivity and their functional implications.…”

Section: Testing Connectivity Predictions Using Structural Connectivitymentioning

confidence: 87%

“…Considerable advances have been made in establishing structural connectivity based on EM reconstruction (Takemura et al 2013; W.-C. A. Lee et al 2016; Zheng et al 2018), viral projection-labeling (Ugolini 1995; Wickersham et al 2007; Wall et al 2010; Eastwood et al 2019; Oh et al 2014) and RNA barcoding (Chen et al 2019; Sun et al 2021) approaches. There have been numerous critiques of such approaches in understanding network computation (Bargmann and Marder 2013; Gomez-Marin 2021). Our analysis bridges such structural observations of connectivity and their functional implications.…”

Section: Discussionmentioning

confidence: 99%

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Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

Somashekar,

Bhalla

2024

Preprint

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Co-active or temporally ordered neural ensembles are a signature of salient sensory, motor, and cognitive events. Local convergence of such patterned activity as synaptic clusters on dendrites could help single neurons harness the potential of dendritic nonlinearities to decode neural activity patterns. We combined theory and simulations to assess the likelihood of whether projections from neural ensembles could converge onto synaptic clusters even in networks with random connectivity. Using rat hippocampal and cortical network statistics, we show that clustered convergence of axons from 3-4 different co-active ensembles is likely even in randomly connected networks, leading to representation of arbitrary input combinations in at least ten target neurons in a 100,000 population. In the presence of larger ensembles, spatiotemporally ordered convergence of 3-5 axons from temporally ordered ensembles is also likely. These active clusters result in higher neuronal activation in the presence of strong dendritic nonlinearities and low background activity. We mathematically and computationally demonstrate a tight interplay between network connectivity, spatiotemporal scales of subcellular electrical and chemical mechanisms, dendritic nonlinearities, and uncorrelated background activity. We suggest that dendritic clustered and sequence computation is pervasive, but its expression as somatic selectivity requires confluence of physiology, background activity, and connectomics.

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Section: Testing Connectivity Predictions Using Structural Connectivitymentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

Somashekar,

Bhalla

2024

Preprint

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“…For the moment, there is no sign of either the wiring diagram or circuit diagram metaphor going out of fashion. Even scientists who are critical of the emphasis on connectomics happily use the wiring diagram metaphor (e.g., Barack and Krakauer, 2021;Gomez-Marin, 2021). For the moment there is little reason why these metaphors should be dropped -they serve a useful function for both scientists and the general public, explaining anything from a connectome to a neural network in a simple way and suggesting a link between structure and function.…”

Section: Connectomesmentioning

confidence: 99%

A Brief History of Wires in the Brain

Cobb

2021

Front. Ecol. Evol.

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Metaphors have formed a significant part of the development of neuroscience, often linked with technology. A metaphor that has been widely used for the past two centuries is that of the nervous system being like wires, either as a telegraph system or telephone exchange, or, more recently, in the more abstract metaphor of a wiring diagram. The entry of these terms into scientific writing is traced, together with the insights provided by these metaphors, in particular in relation to recent developments in the study of connectomes. Finally, the place of the wiring diagram as a modern version of Leibniz’s “mill” argument is described, as a way of exploring the limits of what insight the metaphor can provide

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“…We are witnessing a technological revolution in the field of neuroscience, with increasingly large-scale neurophysiological recordings in behaving animals (Gao & Ganguli, 2015) combined with the high-dimensional monitoring of behavior (Musall et al, 2019;Pereira et al, 2020) and causal interventions (Jazayeri & Afraz, 2017) at its forefront. Yet, behavioral experiments remain an essential tool to investigate the mysteries underlying the human mind (Gomez-Marin, 2021;Niv, 2020;Read, 2015) -especially when combined with computational modeling (Ma & Peters, 2020;Wilson & Collins, 2019) -and constitute, compared to other approaches in neuroscience, an affordable and accessible approach. Ultimately, measuring behavior is the most effective way to gauge the ecological relevance of cognitive processes (Gomez-Marin, 2021;Krakauer et al, 2017;Niv, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Yet, behavioral experiments remain an essential tool to investigate the mysteries underlying the human mind (Gomez-Marin, 2021;Niv, 2020;Read, 2015) -especially when combined with computational modeling (Ma & Peters, 2020;Wilson & Collins, 2019) -and constitute, compared to other approaches in neuroscience, an affordable and accessible approach. Ultimately, measuring behavior is the most effective way to gauge the ecological relevance of cognitive processes (Gomez-Marin, 2021;Krakauer et al, 2017;Niv, 2020).…”

Section: Introductionmentioning

confidence: 99%

A practical guide for studying human behavior in the lab

et al. 2022

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This primer introduces best practices for designing behavioral experiments, data collection, analysis, and sharing, as well as research ethics and subject care, to beginners and experienced researchers from diverse backgrounds. Organized by topics and frequent questions, this piece provides an accessible overview for those who are embarking on their first journey in the field of human behavioral neuroscience.

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Promisomics and the Short-Circuiting of Mind

Cited by 11 publications

References 55 publications

Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

A Brief History of Wires in the Brain

A practical guide for studying human behavior in the lab

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