Promoted removal of phosphate by layered double hydroxides combined with bacteria: Application of novel carriers in biofilm reactor

He, Xiao-Song; Xie, Xin; Xu, Huanle; Liu, Jingxuan; Li, Bo-Lin; Zhang, Qiwu

doi:10.1016/j.biortech.2022.126879

Cited by 13 publications

(3 citation statements)

References 40 publications

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“…[ 80 , 81 ] Moreover, because the cell membranes and bacterial films both possess negative charges, [ 82 ] LDHs with positive charges are more likely to bind to them, thereby improving the binding of LDHs drug carries to cell membranes and bacterial films, and thus improving the efficiency of drug delivery and antibacterial effects. [ 83 , 84 , 85 ] Above all, the ideal biomedical materials should meet complex biomedical application needs, and the flexibility and adjustability of LDHs' structure and composition can enable them to meet various biomedical application challenges. Moreover, the abundant hydroxyl groups on the surface of LDHs and the layer plates with positive charges make it easy to construct multifunctional composites through chemical modification or charge adsorption with other biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Li,

Soyhan,

Warszawik

et al. 2024

Advanced Science

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Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in the structural composition and ease of surface modification of LDHs makes it possible to develop specifically functionalized LDHs to meet the needs of different applications. In this review, the recent advances of LDHs for biomedical applications, which include LDH‐based drug delivery systems, LDHs for cancer diagnosis and therapy, tissue engineering, coatings, functional membranes, and biosensors, are comprehensively discussed. From these various biomedical research fields, it can be seen that there is great potential and possibility for the use of LDHs in biomedical applications. However, at the same time, it must be recognized that the actual clinical translation of LDHs is still very limited. Therefore, the current limitations of related research on LDHs are discussed by combining limited examples of actual clinical translation with requirements for clinical translation of biomaterials. Finally, an outlook on future research related to LDHs is provided.

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Section: Introductionmentioning

confidence: 99%

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Li,

Soyhan,

Warszawik

et al. 2024

Advanced Science

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“…In the past 5 years, layered double hydroxides (LDH) are broadly investigated as nanovectors due to their good hydrophilicity and biocompatibility. − Various systems based on LDH have been constructed for the application of photodynamic therapy, chemodynamic therapy, sonodynamic therapy-enhanced immunotherapy, and so on. − The layered structure and ion exchange capacity endow LDH with high surface hydrophilicity . In addition, the abundant positive charge on the surface of LDH enables stable electrostatic interaction with negatively charged bacteria .…”

Section: Introductionmentioning

confidence: 99%

Integration of CoAl-Layered Double Hydroxides on Commensal Bacteria to Enable Targeted Tumor Inhibition and Immunotherapy

Zhou,

Chen,

Zheng

et al. 2023

ACS Appl. Mater. Interfaces

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Combining targeted therapy and immunotherapy brings hope for a complete cancer cure. Due to their selective colonization and immune activation capacity, some bacteria have the potential to realize targeted immunotherapy. Herein, a biohybrid system was designed and synthesized by cladding NO 3 − -intercalated cobalt aluminum layered double hydroxides (LDH) on anaerobic Propionibacterium acnes (PA) (PA@LDH). In this system, the covering of LDH reduces the pathogenicity of PA to normal tissues and alters its surface charge for prolonged in vivo circulation. Once the tumor site is reached, the acid-responsive degradation of LDH enables PA exposure. PA can colonize and convert nitrate ions to nitric oxide (NO) through denitrification. Then, NO reacts with intracellular O 2•− to produce toxic reactive nitrogen species ONOO − and induce tumor cell apoptosis. In addition, cobalt ions released from LDH can inhibit the activity of superoxide dismutase (SOD), thus increasing the level of O 2•− and further enhancing the antitumor effect. Moreover, PA exposure activates M2-to-M1 macrophage polarization and a range of immune responses, thereby achieving a sustained antitumor activity. In vitro and in vivo results reveal that the biohybrid system eliminates solid tumors and inhibits tumor metastasis effectively. Overall, the biohybrid strategy provides a new avenue for realizing simultaneous immunotherapy and targeted therapy.

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“…Additionally, the layer plates of LDHs possess positive charges, which makes it easy to modify LDHs through simple charge adsorption to improve their stability in vivo or perform functional modifications to meet different biomedical applications' needs [78,79] . Moreover, because the cell membranes and bacterial films both possess negative charges [80] , so LDHs with positive charges are more likely to bind to them, thereby improving the binding of LDHs drug carries to cell membranes and bacterial films, and thus improving the efficiency of drug delivery and antibacterial effects [81][82][83] . Above all, the ideal biomedical materials should meet complex biomedical application needs, and the flexibility and adjustability of LDHs' structure and composition can enable them to meet various biomedical application challenges.…”

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confidence: 99%

Biomedical relevant layered double hydroxides as versatile drug carriers and nanofillers

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Ⅰ Layered double hydroxides as drug delivery systemsLDHs possess a remarkable and significant characteristic, namely the interchangeability of their interlayer anions. This unique feature enables the intercalation of diverse organic anions [20] , inorganic anions [21] , polymetric anions [22] , and drug molecules [23] within the LDHs' interlayer, resulting in a range of distinct functionalities. Previous investigations have successfully demonstrated the efficacy of LDHs as carriers for various therapeutic agents, including anti-inflammatory drugs [24] , antimicrobial agents [25] , and adjuvants for DNA vaccines [26] . In the realm of drug delivery systems, LDHs offer several advantages, such as enhanced solubility, diffusion properties, and thermal stability of the loaded drug molecules, as well as the ability to achieve a controlled release rate without inducing adverse effects on the human body [27] . Meyn et al. conducted a comprehensive study on the anion exchange capacity of LDHs, revealing a preference for anion exchange as follows: CO3 2-> SO4 2-> HPO4 2-> OH -> F -> Cl -> Br -> NO3 - [28] . Consequently, in current research pertaining to LDHs as drug carriers, particular emphasis has been placed on investigating nitratetype and chloride-type LDHs due to their remarkable ion exchange capacity [29,30] . However, despite numerous studies focusing on the drug release characteristics of LDHs, limited research has delved into comprehensive characterizations of the post-release particles. While many studies attribute the pH-responsive release of LDHs under acidic conditions to partial dissolution [31][32][33] , there is insufficient data to substantiate this claim. Relying solely on the drug release behavior of LDH carriers without proper supporting data and mechanistic understanding may impede the development of LDHs for appropriate applications. Thus, it is crucial to acquire novel and in-depth mechanistic insights into the post-release behavior and structural changes of LDHs, offering valuable knowledge in this field. Additionally, despite extensive investigations on LDHs as drug delivery systems, the majority of successfully loaded drug molecules have been anionic in nature, primarily due to the inherent structural characteristics of LDHs. The positively charged layer plates of LDHs necessitate the presence of negatively charged anions to maintain structural stability by balancing the charge between the layers [34] . Consequently, the commonly employed ion-exchange drug loading strategy poses significant challenges when attempting to load hydrophobic drugs onto LDH carriers, as these drugs typically exist in a non-ionic state in their active form. As a result, research on LDHs as carriers for hydrophobic drugs has remained limited thus far, despite the significant proportion of hydrophobic drugs within the pharmaceutical field. Notably, numerous important drugs, including anticancer agents [35] , cardiovascular drugs [36] , antibiotics [37] , and central nervous system drugs [38] , fall into t...

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Promoted removal of phosphate by layered double hydroxides combined with bacteria: Application of novel carriers in biofilm reactor

Cited by 13 publications

References 40 publications

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Integration of CoAl-Layered Double Hydroxides on Commensal Bacteria to Enable Targeted Tumor Inhibition and Immunotherapy

Biomedical relevant layered double hydroxides as versatile drug carriers and nanofillers

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