Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis
Yonghwan Shin,
Sungmin Kim,
Woojin An
Abstract:Despite growing evidence implicating the calcium-activated chloride channel anoctamin1 (ANO1) in cancer metastasis, its direct impact on the metastatic potential of prostate cancer and the possible significance of epigenetic alteration in this process are not fully understood. Here, we show that ANO1 is minimally expressed in LNCap and DU145 prostate cancer cell lines with low metastatic potential but overexpressed in high metastatic PC3 prostate cancer cell line. The treatment of LNCap and DU145 cells with DN… Show more
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