Promoter Hypermethylation of LATS2 Gene in Oral Squamous Cell Carcinoma (OSCC) Among North Indian Population.

Abstract

2013). Oncogenes and Tumor Suppressor genes promote Tumorigenesis (Hanahan and Weinberg 2000). The down-regulation of Tumor Suppressor genes is introduced through several epigenetic modifications, mutations, loss of heterozygosity and deletions (Perez-Sayans et al., 2009). The epigenetic changes refer to any mitotically heritable alteration in gene expression without changes of

A compendium of population wide DNA methylation profile for oral cancer in India

“…[21] LATS2 gene promoter hypermethylation was statistically significant in tobacco chewers and smokers. [24] Comparative analysis with the TCGA-HNSCC data revealed 94.6% similarities by Basu et al and 80.4% similarities by Das et al [26,28] Khongsti et al found approximately 29.54% similarities in hypermethylated genes of promoter region. Among 38 genes hypermethylated in promoter region reported by them, 14 genes were similar to TCGA-HNSCC study.…”

“…[18] The key characteristics of reviewed studies are summarized in Table 1. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] The studies included different sets of population across the states of India. There is heterogeneity among the studies regarding type of sample, sample size, control sampling, socio-economic, and lifestyle (e.g., gutkha, tobacco, and alcohol) characteristics and methylation percent, with less emphasis on data from controls.…”

“…Most of the reviewed studies included paired control samples from the same individual adjacent to the tumor tissue to reduce the potential confounding bias. Notably, saliva, [18] scrape, [19] and blood [18,[20][21][22][23][24] were also used for analysis. Recently, the use of whole blood and saliva in methylation studies has become common as potential non-invasive mediums for investigation.…”

A Review on Current Scenario of Oral Cancer in India With Special Emphasis on Modern Detection Systems and Biomarkers

“…Microscopic examination of tissue for the assessment of epithelial dysplasia [40]. Microscopic examination of disaggregated cells for the assessment of cellular dysplastic changes [4].…”

“…Oral cancer (International classification of diseases, 10 th edition, ICD-10 codes: C00-C08) ranks 15 th globally with high prevalence and mortality in less developed countries. About 90% of oral cancers are oral squamous cell carcinoma (OSCC) [3,4]. OSCC includes anatomical sites such as lip mucosa, dorsal, ventral, and border of the anterior two-third of the tongue, vestibule, gums, hard palate, chick mucosa and retromolar area.…”