Promoter identification of CIKS, a novel NF-κB activating gene, and regulation of its expression

Pacifico, Francesco; Barone, C; Mellone, Stefano; Jeso, Bruno Di; Consiglio, Eduardo; Formisano, Silvestro; Vito, Pasquale; Leonardi, Antonio

doi:10.1016/s0378-1119(03)00448-7

Cited by 1 publication

(1 citation statement)

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“…[26][27][28][29] The production of MMP, as well as of inflammatory mediators such as tumour necrosis factor a and interleukin 1b, is regulated by the transcription factor nuclear factor kB, the activity of which appears to be influenced by silica exposure. [30][31][32][33][34] …”

Section: Discussionmentioning

confidence: 99%

Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study

Stolt

Källberg

Lundberg

et al. 2005

Annals of the Rheumatic Diseases

179

123

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Objective: To study the association between silica exposure and rheumatoid arthritis and how it is modified by cigarette smoking. Methods: Data were analysed from 276 male cases and 276 male controls aged 18 to 70 years, included in a Swedish population based study between May 1996 and June 2001. A case was defined as a person recently diagnosed with rheumatoid arthritis according to the ACR criteria. Controls were selected from the study base as a stratified random sample accounting for age, sex, and residency. Men with a self reported history of work with rock drilling, stone crushing, or exposure to stone dust in general were defined as silica exposed. Rheumatoid factor (RF) status among cases was recorded. Results: Silica exposed men had increased risk of rheumatoid arthritis, with an odds ratio (OR), adjusted for age, residential area, and smoking, of 2.2 (95% confidence interval, 1.2 to 3.9) among men aged 18 to 70 years, and 2.7 (1.2 to 5.8) among those aged 50 to 70 years. Men who had worked with rock drilling or stone crushing (regarded as highly exposed) had a slightly greater increase in risk of rheumatoid arthritis than silica exposed men in general, with an OR of 3.0 (1.2 to 7.6). The joint effects of silica exposure and smoking were compatible with synergy between these two exposures in the development of rheumatoid arthritis but this was not conclusive. Conclusions: Silica exposure is associated with increased risk of developing rheumatoid arthritis. This association is not explained by smoking habits.

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