Promoter Polymorphism (−308G/A) of Tumor Necrosis Factor-Alpha (<i>TNF-α</i>) Gene and Asthma Risk: An Updated Meta-Analysis

Kang, Sang Wook; Kim, Su Kang; Han, Young Rok; Hong, DongWhan; Chon, Jinmann; Chung, Joo‐Ho; Hong, Seoung-Jin; Park, Minsu; Ban, Ju Yeon

doi:10.1089/gtmb.2018.0238

Cited by 8 publications

(6 citation statements)

References 70 publications

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“…These genes are also shown to be associated with asthma based on genome-wide association studies [28][29][30]. In addition, TNF-α (gene related non-classic MHC molecules) also contribute to MG and asthma predisposition [26,31,32] Lastly, asthma and MG may share some common environmental risk factors. Viral infections are important trigger of acute wheezing episodes in infancy and the inception and exacerbation of asthma [33].…”

Section: Discussionmentioning

confidence: 99%

The Association Between Asthma and Risk of Myasthenia Gravis: A Systematic Review and Meta-analysis

Yingchoncharoen

Charoenngam

Ponvilawan

et al. 2021

Lung

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This study aimed to investigate the association between asthma and risk of myasthenia gravis (MG) using the method of systematic review and meta-analysis. MethodsPotentially eligible studies were identi ed from Medline and EMBASE databases from inception to … using search strategy that comprised of terms for "Asthma" and "Myasthenia Gravis". Eligible cohort study must consist of one cohort of individuals with asthma and another cohort of individuals without asthma. Then, the study must report relative risk (RR) with 95% con dence intervals (95% CIs) of incident MG between the groups. Eligible case-control studies must include cases with MG and controls without MG. Then, the study must explore their history of asthma. Odds ratio (OR) with 95% CIs of the association between asthma status and MG must be reported. Point estimates with standard errors were retrieved from each study and were combined together using the generic inverse variance method. ResultsA total of 6,835 articles were identi ed. After two rounds of independent review by ve investigators, two cohort studies and three case-control studies met the eligibility criteria and were included into the metaanalysis. Pooled analysis showed that asthma was signi cantly associated with risk of MG with the pooled risk ratio of 1.38 (95%CI, 1.02 -1.86). Funnel plot was symmetric. ConclusionThe current study found a signi cant association between asthma and increased risk of MG.

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Section: Discussionmentioning

confidence: 99%

The Association Between Asthma and Risk of Myasthenia Gravis: A Systematic Review and Meta-analysis

Yingchoncharoen

Charoenngam

Ponvilawan

et al. 2021

Lung

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“…Our results suggest that naringenin could markedly decrease the release of IL-8 and TNF-α, protecting cells from CSE-induced inflammatory reaction. IL-8 and TNF-α are essential inflammatory cytokines of pulmonary illnesses [ 52 , 53 ]. Clinical studies have demonstrated the correlation between pulmonary illnesses and the content of IL-8 and TNF-α [ 54 ], and strong correlations have been found between the number of sputum cells (macrophages and neutrophils) and proinflammatory cytokine levels (IL-8 and TNF-α) [ 55 ], suggesting that IL-8 and TNF-α are suitable for evaluating the inflammatory reaction in BEAS-2B cells.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis

Chen

Xiao

et al. 2020

Molecules

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Naringenin is found mainly in citrus fruits, and is thought to be beneficial in the prevention and control of lung diseases. This study aims to investigate the mechanisms of naringenin against the damage in the lung caused by cigarette smoke. A system bioinformatic approach was proposed to predict the mechanisms of naringenin for protecting lung health. Then, we validated this prediction in BEAS-2B cells treated with cigarette smoke extract (CSE). System bioinformatic analysis indicated that naringenin exhibits protective effects on lung through the inhibition of inflammation and suppression of oxidative stress based on a multi-pathways network, mainly including oxidative stress pathway, Nrf2 pathway, Lung fibrosis pathway, IL-3 signaling pathway, and Aryl hydrocarbon receptor pathway. The in vitro results showed that naringenin significantly attenuated CSE-induced up-regulation of IL-8 and TNF-α. CSE stimulation increased the mRNA expressions of Nrf2, HO-1, and NQO1; the levels of total protein and nuclear protein of Nrf2; and the activity of SOD on days 2 and 4; but decreased these indexes on day 6. Naringenin can balance the antioxidant system by regulating Nrf2 and its downstream genes, preliminarily validating that Nrf2 pathway is involved in the protection offered by naringenin against cigarette smoke-induced damage to the lung. It suggests that dietary naringenin shows possible potential use in the management of lung health.

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“…Data about promoter polymorphism -308 (G/A) (rs1800629) of TNF-α depict its involvement in the immune response set up and maintenance in different clinical scenarios, but the explanation of the related molecular mechanism is still pending. The minor allele A was described as associated with the risk of inflammatory disorders, sepsis, chronic obstructive pulmonary disease and asthma, whereas it confers protection against Dengue fever and has no effect on Kawasaki disease [133][134][135][136][137][138]. In addition, it exhibits a relation with increased serum TNF-α levels in asthma and not uniformly in cancer patients, but an analogous influence on transcription was not detected in other contexts like Alzheimer's disease and generalized vitiligo [139][140][141][142][143].…”

Section: Other Cytokines Chemokines and Their Signaling Pathwaysmentioning

confidence: 99%

The Role of Immunogenetics in COVID-19

Pojero

Candore

Caruso

et al. 2021

IJMS

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Coronavirus disease 2019 (COVID-19) is induced by SARS-CoV-2 and may arise as a variety of clinical manifestations, ranging from an asymptomatic condition to a life-threatening disease associated with cytokine storm, multiorgan and respiratory failure. The molecular mechanism behind such variability is still under investigation. Several pieces of experimental evidence suggest that genetic variants influencing the onset, maintenance and resolution of the immune response may be fundamental in predicting the evolution of the disease. The identification of genetic variants behind immune system reactivity and function in COVID-19 may help in the elaboration of personalized therapeutic strategies. In the frenetic look for universally shared treatment plans, those genetic variants that are common to other diseases/models may also help in addressing future research in terms of drug repurposing. In this paper, we discuss the most recent updates about the role of immunogenetics in determining the susceptibility to and the history of SARS-CoV-2 infection. We propose a narrative review of available data, speculating about lessons that we have learnt from other viral infections and immunosenescence, and discussing what kind of aspects of research should be deepened in order to improve our knowledge of how host genetic variability impacts the outcome for COVID-19 patients.

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Promoter Polymorphism (−308G/A) of Tumor Necrosis Factor-Alpha (TNF-α) Gene and Asthma Risk: An Updated Meta-Analysis

Cited by 8 publications

References 70 publications

The Association Between Asthma and Risk of Myasthenia Gravis: A Systematic Review and Meta-analysis

The Association Between Asthma and Risk of Myasthenia Gravis: A Systematic Review and Meta-analysis

Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis

The Role of Immunogenetics in COVID-19

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