Promoter polymorphism of transforming growth factor-β1 gene and ulcerative colitis

Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis

“…The serum levels of TGF-1 and its mRNA expression level 31 are known to increase in IBD patients. A polymorphism of the TGF-1 gene was found to be associated with stricturing CD 4 and UC 5 . Therefore, this study examined the expression 26 of TGF-1, and demonstrated that poly P treatment downregulated the expression of TGF-1 in both the DSS-or TNBS-induced models of colitis.…”

“…Phosphorylated TGF-1 produced by intestinal epithelial cells and macrophages facilitates the transfer of smad 2/3 and smad 4 from the cytoplasm to the nucleus and promotes the transcription of collagen mRNA in intestinal fibroblasts, thereby inducing the development of intestinal fibrosis [1][2][3] . Recent genome-wide studies have identified a TGF-1 variant to be associated with stricturing CD and UC, suggesting the presence of a strong association 7 between intestinal fibrosis and abnormalities in TGF-1 4,5 . CTGF is associated with wound healing and fibrotic pathology, particularly the induction of sustained fibrosis under cooperation with TGF-1.…”

Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor β1 gene.

“…It was postulated that the TT genotype at the -509 position of the TGF-β1 locus was associated with the stricture forming type of the CD (Schulte et al, 2001), and this type of the disease was also associated with a particular genotype at the 915 position (G/C polymorphism) (Hume et al, 2006). Moreover, significant differences in allele frequencies and genotypes at the -800 position (G/A polymorphism) of the TGF-β1 locus were found between patients with UC and control subjects (Tamizifar et al, 2008). However, to our knowledge, all studies on the role of TGF-β1 polymorphisms in IBD reported to date were performed in adult patients.…”

“…Among them, the following four are the most frequent: -800G/A and -509C/T in the promoter region, and 869T/C and 915G/C in exon 1, as shown in Fig 1 (Bayat et al, 2002;Kim et al, 2003;Suzuki et al, 2003;Lee-Chen et al, 2004;Osterreicher et al, 2005). Because of this, and due to the fact that some effects of TGF-β1 polymorphism on IBD was reported to date only for -800G/A, -509C/T and 915G/C (Schulte et al, 2001;Hume et al, 2006;Tamizifar et al, 2008), in our studies we have tested these four polymorphisms.…”

TGFB1 Gene Promoter Polymorphisms in Serbian Asthmatics

“…A C to G transition at position -509 in the TGFB1 gene promoter has been widely studied as a risk factor for asthma and other inflammatory diseases [13,14]. This polymorphism is located in the silencer region of the TGFB1 gene in a Yin Yang 1 (YY1) consensus binding site, and the presence of the T allele increases basal promoter activity by approximately 30% [15].…”