Promoter polymorphisms of tumor necrosis factor‐α are associated with risk of gastric mucosa–associated lymphoid tissue lymphoma

Wu, Ming–Shiang; Chen, Li-Tzong; Shun, Chia‐Tung; Huang, Shih-Pei; Chiu, Han–Mo; Wang, Hsiu-Po; Lin, Mei-Chi; Cheng, Ann‐Lii; Lin, Jaw–Town

doi:10.1002/ijc.20199

Cited by 55 publications

(53 citation statements)

References 49 publications

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“…As a result, 53 articles were excluded as they failed to meet eligibility criteria, due to not investigating IL‐1B 31 polymorphism, or not case–control study. Of the remaining 38 publications, three were eliminated, due to reporting duplicate data 17, 18, 19. Ultimately, 37 studies from 35 publications 6, 10, 14, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 including 6108 cases and 8980 controls were included in the meta‐analysis (Fig.…”

Section: Resultsmentioning

confidence: 99%

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Hua-yong

Zong³

et al. 2016

J Cellular Molecular Medi

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Gastric cancer is one of the most common malignancies worldwide. Interleukin‐1‐beta (IL‐1β) is a pro‐inflammatory cytokine and potent inhibitor of gastric acid secretion. Some studies provided evidence of the association between IL‐1B 31 polymorphism and gastric cancer risk while other studies did not. Therefore, we conducted a comprehensive meta‐analysis to reassess the association. A systematic literature search of the PubMed and EMBASE databases identified 37 studies with 6108 cases and 8980 controls for this meta‐analysis. The crude odd ratios (ORs) and the 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Meta‐regression was used to determine the major source of heterogeneity across the studies. The pooled analysis did not suggest the significant association of IL‐1B 31 C>T polymorphism with gastric cancer risk. Stratified analysis was performed by ethnicity, source of control, genotype method, and indicated a significantly increased gastric cancer risk associated with IL‐1B 31T variant in the population‐based subgroup (heterozygous model: OR = 1.22, 95% CI = 1.03–1.45). Moreover, stratified analysis by Helicobacter pylori infection status indicated that IL‐1B 31 polymorphism increased gastric cancer risk in infection‐positive subgroup (homozygous model: OR = 1.35, 95% CI = 1.02–1.78; heterozygous model: OR = 1.31, 95% CI = 1.04–1.66; recessive model: OR = 1.29, 95% CI = 1.04–1.61). The study suggested that IL‐1B 31 polymorphism might confer susceptibility to gastric cancer in the presence of H. pylori infection, indicating a gene–environment interaction in gastric carcinogenesis.

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Section: Resultsmentioning

confidence: 99%

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Hua-yong

Zong³

et al. 2016

J Cellular Molecular Medi

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“…The filled diamond represents the combined odds ratio and 95% confidence interval Table 6. Statistics to test publication bias and heterogeneity in the meta-analysis (Caucasians) controls from Hubei province (9,36), Henan province (13), Taiwan (11,12) and Nanjing (8). However, other reports from Beijing (10) and Hubei province (7) showed a lower prevalence of heterozygous mutations (8-9%).…”

Section: Discussionmentioning

confidence: 99%

“…An association of TNF-α -308G>A (rs1800629) with susceptibility/resistance to GC development has been widely investigated and yielded conflicting results. Studies including GC patients and controls from China (7)(8)(9)(10)(11)(12)(13)(14), Brazil (15,16), Portugal (17,18), United States (19), Poland (20), South Korea (21-23), Honduras (24), Italy (25), Colombia (26), and Japan (27) have been associated with susceptibility to GC development. However, other studies including those from India (28), Brazilian (29,30), Romania (31), Spain (32,33), South Korea (34,35), China (36), Mexico (37), Germany (38) and Finland (39) failed to show a possible link between the TNF-α (-308G>A) polymorphism and GC.…”

Section: Introductionmentioning

confidence: 99%

Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis

Du¹,

Gao²

2017

Turk J Gastroenterol

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Background/Aims: In the Chinese population, gastric cancer (GC) is ranked as the third most common type of cancer. Although the exact etiology of GC development is unclear, several factors, including genetic and environmental, have been identified as risk factors. Variations in cytokine genes and their receptors have been related to a higher risk of GC. A single nucleotide polymorphism in the promoter region of tumor necrosis factor-α (TNF-α) (-308G>A) has been associated with a higher risk of GC and in the present study we evaluated its possible association with GC in a Chinese cohort. In addition, we performed a meta-analysis to draw a firm conclusion about the association between TNF-α gene polymorphisms and GC. Materials and Methods: We enrolled 400 Chinese GC patients and matched healthy controls hailing from similar geographical areas. The TNF-α -308G/A polymorphism was genotyped by allele-specific polymerase chain reaction (AS-PCR). For the meta-analysis, earlier published articles were searched and eligible studies were included. Results: Prevalence of the heterozygous mutant (GA) and minor allele (A) were significantly higher in GC cases compared to healthy controls (GA: p<0.0001, odds ratio (OR)=4.90; A: p<0.0001, OR=2.84). A total of 36 eligible studies including the present report, encompassing of 8353 GC patients and 12099 controls, were analyzed for the meta-analysis. A significant association of the TNF-α polymorphism (-308G>A) with susceptibility to GC was only found in the Caucasian population (A vs G: p=0.001; AA vs GG: p=0.01; AG vs GG: p<0.0001; AA vs AG+GG: p=0.01; AA+AG vs p=0.003). Conclusion:The results of the present case control study and meta-analysis showed that associations between TNF-a variants with susceptibility to GC development is population and ethnic specific. Keywords: Gene polymorphism, TNF-α, gastric cancer, meta-analysis, association, Chinese Original ArticleCite this article as: Du LC, Gao R. Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: a case control study and metaanalysis. Turk J Gastroenterol 2017; 28: 272-82.

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“…14 Since there is interaction between the infective organism and the infected host, it is interesting to investigate the significance of IL-1 gene polymorphism in patients harboring GC with or without the association of EBV, and such an issue has not been investigated until recently. 15,16 We also focused on the topographic features of GC in our study. Although there has been a steady rise in the incidence of adenocarcinoma of the proximal stomach (gastric cardia) and the gastroesophageal junction in western countries, gastric cardia is a narrow zone at the esophagogastric junction (0.1-3mm) without gastroesophageal reflux disease, 17 and the adenocarcinoma of the cardia in a strict definition remains rare in Japan.…”

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confidence: 99%

Cancer risk to the gastric corpus in Japanese, its correlation withinterleukin‐1βgene polymorphism (+3953*T) and Epstein‐Barr virus infection

Sakuma

Uozaki

Chong

et al. 2005

Intl Journal of Cancer

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Polymorphisms of interleukin-1 (IL-1) genes have been reported to modify the risk of gastric carcinoma (GC) in Caucasians. The significance of IL-1b gene polymorphisms was evaluated in Japanese GC patients with or without infection of Helicobacter pylori and Epstein Barr virus (EBV) with special reference to the topographic features of GC. IL-1b gene polymorphisms at positions -511 and +3953 were evaluated by PCR-RFLP and a penta-allelic polymorphism of IL-1RA by PCR in healthy controls (n = 103) and GC (n =140; corpus 95, antrum 45). EBV-infection was determined in the neoplastic tissues by EBER1 in situ hybridization, and H. pylori infection in nonneoplastic gastric mucosa by PCR targeting of the H. pylori urease A gene. GC consisted of EBV-associated (n = 24) and EBV-negative (n = 116) patients, whereas H. pylori infection was positive in 130 cases. Among IL-1b gene polymorphisms, genotype IL-1b+3953 C/T was more frequent in the EBV-negative (21%) and corpus GC (23%) patients, compared to the controls (10%), respectively, although there was no genotype IL-1b+3953 T/T in either group. Thus, the effect of IL-1b+3953 T was statistically significant in logistic regression models adjusted for age in EBV negativity (odds ratio [OR] 2.27, 95% confidence interval [CI] 1.02-5.05) and in the corpus GC (2.70, 1.19-6.12) with highest OR 3.55 (1.54-8.23) in EBV-negative corpus GC. There was no significant influence of IL-1 gene polymorphism in EBV-associated GC, but it occurred predominantly in the corpus (24/24) compared to EBV-negative GC (71/116) (p = 0.00002). There was no correlation between H. pylori infection and IL-1 gene polymorphism in GC. The cancer risk of the gastric corpus in Japanese is influenced by IL-1b+3953 polymorphisms. On the other hand, the risk of EBV-associated GC, which occurs predominantly in the corpus, is not influenced by this pro-inflammatory polymorphism. ' 2005 Wiley-Liss, Inc.

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Promoter polymorphisms of tumor necrosis factor‐α are associated with risk of gastric mucosa–associated lymphoid tissue lymphoma

Cited by 55 publications

References 49 publications

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis

Cancer risk to the gastric corpus in Japanese, its correlation withinterleukin‐1βgene polymorphism (+3953*T) and Epstein‐Barr virus infection

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