Promoting athero-protective immunity by vaccination with low density lipoprotein-derived antigens

Nilsson, Jan; Shah, Prediman K.

doi:10.1016/j.atherosclerosis.2021.08.033

Cited by 6 publications

(2 citation statements)

References 124 publications

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“…Pioneering studies by Pakinski and Ameli on hypercholesterolemic rabbits showed the atheroprotective effect of immunization with modified LDL; this, in turn, fueled the use of ApoB peptides, that are specifically MHC II restricted, to trigger a CD4 + T cell response (132) and Treg increase (131), as a vaccination strategy in experimental atherosclerosis (132)(133)(134)(135). Despite some MHC-I epitopes against murine and human ApoB have also been identified, the largest effort has been devoted in identifying MHC-II-restricted epitopes of ApoB (3), that could evoke a robust and atheroprotective response.…”

Section: Targeting Dendritic Cell-t Cell Axis In Atherosclerosismentioning

confidence: 99%

Crosstalk between dendritic cells and T lymphocytes during atherogenesis: Focus on antigen presentation and break of tolerance

Bellini

Bonacina

Norata

2022

Front. Cardiovasc. Med.

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Atherosclerosis is a chronic disease resulting from an impaired lipid and immune homeostasis, where the interaction between innate and adaptive immune cells leads to the promotion of atherosclerosis-associated immune-inflammatory response. Emerging evidence has suggested that this response presents similarities to the reactivity of effector immune cells toward self-epitopes, often as a consequence of a break of tolerance. In this context, dendritic cells, a heterogeneous population of antigen presenting cells, play a key role in instructing effector T cells to react against foreign antigens and T regulatory cells to maintain tolerance against self-antigens and/or to patrol for self-reactive effector T cells. Alterations in this delicate balance appears to contribute to atherogenesis. The aim of this review is to discuss different DC subsets, and their role in atherosclerosis as well as in T cell polarization. Moreover, we will discuss how loss of T cell tolerogenic phenotype participates to the immune-inflammatory response associated to atherosclerosis and how a better understanding of these mechanisms might result in designing immunomodulatory therapies targeting DC-T cell crosstalk for the treatment of atherosclerosis-related inflammation.

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Section: Targeting Dendritic Cell-t Cell Axis In Atherosclerosismentioning

confidence: 99%

Crosstalk between dendritic cells and T lymphocytes during atherogenesis: Focus on antigen presentation and break of tolerance

Bellini

Bonacina

Norata

2022

Front. Cardiovasc. Med.

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“…It is believed that atherosclerosis is a chronic immune-inflammatory disease ( 3 ). The immune system is indispensable in the induction, progression, and plaque disruption (plaque rupture or plaque erosion) of plaques ( 4 ). Besides, evidence has suggested that activated T cells exist in human atherosclerotic plaques ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

The emerging role of Th1 cells in atherosclerosis and its implications for therapy

et al. 2023

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Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-sized artery walls. The molecular mechanisms regulating the onset and progression of atherosclerosis remain unclear. T cells, one of the most common immune cell types in atherosclerotic plaques, are increasingly recognized as a key mediator in the pathogenesis of atherosclerosis. Th1 cells are a subset of CD4+ T helper cells of the adaptive immune system, characterized by the expression of the transcription factor T-bet and secretion of cytokines such as IFN-γ. Converging evidence shows that Th1 cells play a key role in the onset and progression of atherosclerosis. Besides, Th1 is the central mediator to orchestrate the adaptive immune system. In this review, we aim to summarize the complex role of Th1 cells in atherosclerosis and propose novel preventative and therapeutic approaches targeting Th1 cell-associated specific cytokines and receptors to prevent atherogenesis.

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Letter to the editor regarding the article: “Inflammation and Ischemic heart disease: the next therapeutic target?”

Bronze

2022

Revista Portuguesa de Cardiologia

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Promoting athero-protective immunity by vaccination with low density lipoprotein-derived antigens

Cited by 6 publications

References 124 publications

Crosstalk between dendritic cells and T lymphocytes during atherogenesis: Focus on antigen presentation and break of tolerance

Crosstalk between dendritic cells and T lymphocytes during atherogenesis: Focus on antigen presentation and break of tolerance

The emerging role of Th1 cells in atherosclerosis and its implications for therapy

Letter to the editor regarding the article: “Inflammation and Ischemic heart disease: the next therapeutic target?”

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