The advancement of urban rail transit is increasingly confronted with environmental challenges related to vibration and noise. To investigate the critical issues surrounding vibration propagation and the generation of structure-borne noise, a two-story frame building was selected for on-site measurements of both vibration and its induced structure-borne noise. The collected data were analyzed in both the time and frequency domains to explore the correlation between these phenomena, leading to the proposal of a hybrid prediction method for structural noise that was subsequently compared with measured results. The findings indicate that the excitation of structure-borne noise produces significant waveforms within sound signals. The characteristic frequency of the structure-borne noise is 25–80 Hz, as well as that of the train-induced vibration. Furthermore, there exists a positive correlation between structural vibration and structure-borne noise, whereby increased levels of vibration correspond to more pronounced structure-borne noise; additionally, indoor distribution patterns of structure-borne noise are non-uniform, with corner wall areas exhibiting greater intensity than central room locations. Finally, a hybrid prediction methodology that is both semi-analytical and semi-empirical is introduced. The approach derives dynamic response predictions of the structure through analytical solutions, subsequently estimating the secondary noise within the building’s interior using a newly formulated empirical equation to facilitate rapid predictions regarding indoor building vibrations and structure-borne noises induced by subway train operations.