Promoting Effect of Colostrum on the Phagocytic Activity of Bovine Polymorphonuclear Leukocytes in vitro

Sugisawa, Hitoshi; Itou, Takuya; Sakai, Takeo

doi:10.1159/000047080

Cited by 24 publications

(17 citation statements)

References 19 publications

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“…Background CPM are generally higher in MGL than in PBMC (Parmely et al, 1976;Concha et al, 1980;Nonnecke and Kehrli, 1985), as demonstrated in the current study. Specifically for CMC, this higher background CPM might be explained by the activating effects of colostrum on leukocytes (Sugisawa et al, 2001;Reber et al, 2006). Overall, MGL, both in cattle and in humans, seem not to react as strong as PBMC when confronted in vitro with mitogens and certain antigens (Parmely et al, 1976;Nonnecke and Harp, 1985;Park et al, 1993), as demonstrated in the present study for the mitogen ConA but not for the antigen TT.…”

Section: Discussionsupporting

confidence: 43%

Effect of β-hydroxybutyric acid, parity, and body condition score on phenotype and proliferative capacity of colostral mononuclear leukocytes of high-yielding dairy cows

Meganck

Goddeeris

Campeneere³

et al. 2015

Journal of Dairy Science

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In neonatal calves, the ingestion of colostrum is imperative for preventing infectious diseases. Investigations into the transfer of passive immunity of cattle have primarily focused on the importance of colostral immunoglobulins, with a recent increase in focus on understanding the role of colostral leukocytes. The main objective of the present study was to measure the influence of parity, body condition score, serum nonesterified fatty acids, and serum β-hydroxybutyrate concentrations of periparturient cows on phenotype and mitogen-and antigen-induced proliferative capacity of bovine colostral leukocytes. Holstein-Friesian cows (n = 141) were intramuscularly vaccinated at 60 and 30 d before the expected parturition date with a tetanus toxoid vaccine. Of these 141 animals, 28 primiparous and 72 multiparous cows were sampled immediately after parturition. Colostrum mononuclear cell populations were identified by flow cytometry using bovine cluster of differentiation markers, and the proliferative capacity of these cells was determined using a 3 H-thymidine proliferation assay. Under-conditioned cows had a significantly higher percentage of colostral macrophages than normal-conditioned animals, whereas over-conditioned cows had significantly more colostral B-lymphocytes. Serum β-hydroxybutyrate was significantly associated with higher numbers of colostral T-lymphocytes and macrophages. Heifers had significantly higher mitogen-and antigen-induced proliferation of their colostral leukocytes than third parity or older cows. In conclusion, body condition score, parity, and serum β-hydroxybutyrate concentration of periparturient high-yielding dairy cows were shown to influence the number of colostral macrophages or the mitogen-and antigen-induced proliferation of colostral leukocytes, possibly influencing the cellular immunity of the newborn calf.

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Section: Discussionsupporting

confidence: 43%

Effect of β-hydroxybutyric acid, parity, and body condition score on phenotype and proliferative capacity of colostral mononuclear leukocytes of high-yielding dairy cows

Meganck

Goddeeris

Campeneere³

et al. 2015

Journal of Dairy Science

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“…These are considered as the first line of defense against foreign pathogens (Watzl et al, 2005). Oral administration of bovine colostrum is known to stimulate host non-specific immunity by increasing the systemic immune response or by modulating immunocompetent cell function (Sugisawa et al, 2001). In this study, the phagocytic activity of PBLs was enhanced in rats fed the FDOI diet compared to rats fed either the BD or the IOI diet.…”

Section: Discussionmentioning

confidence: 69%

Immunomodulatory effects of ovine serum immunoglobulin in the growing rat

Balan

Han

Rutherfurd-Markwick

et al. 2010

Animal

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This study aimed to determine whether orally administered ovine serum immunoglobulin (Ig) modulates aspects of immunity such as phagocytosis, lymphocyte proliferation, cytokine production, intestinal and plasma Ig concentrations in growing rats. Forty-five male Sprague-Dawley rats (n 5 15/group) were used in the 21-day study, and fed a basal control diet (BD; no Ig) or two test diets: freeze-dried ovine Ig (FDOI) and inactivated ovine Ig (IOI). Phagocytic activity of peripheral blood leukocytes and lymphocyte proliferation in the presence of the mitogen concanavalin A (ConA) was greater ( P , 0.05) for the FDOI-fed rats than for the BD-and IOI-fed groups. ConA-stimulated and unstimulated spleen cell culture produced higher ( P , 0.05) interferon-g and interleukin-4, respectively, from rats fed the FDOI than rats fed the BD diet. In the jejunum, ileum and plasma, rats fed FDOI produced higher ( P , 0.05) concentrations of secretory IgA (sIgA) than rats fed IOI or BD. Rats fed the FDOI diet had greater jejunal ( P 5 0.037) and lower plasma ( P 5 0.025) rat IgG concentrations than rats fed either BD or IOI. In conclusion, an ovine Ig fraction selectively modulated various indices of immune function.

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“…Sugisawa et al (2001) found that the very high levels of immunoglobulins in colostrum increased the PA by up to 25%, and was dose dependent. PI was highest on day 1, indicating that the engulfment of foreign bodies was also highest at this time.…”

Section: Discussionmentioning

confidence: 92%

Changes in colostrum of Murrah buffaloes after calving

Dang

Kapila

Maneesh

et al. 2008

Trop Anim Health Prod

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Colostrum samples were collected from 8 Murrah buffaloes on days 1, 2, 3, 4 and 5 after calving. Levels of IgG averaged 54.0 mg/ml at calving, then decreased significantly (P < 0.01). IgA and IgM on day 1 were 3.22 mg/ml and 5.22 mg/ml, respectively; both decreased during the first five days after calving. Values of IgA and IgM were higher than those reported in cows. SCC values, which were high at calving (500,000 per ml), reduced significantly (P < 0.01) on day 2, then decreased slightly until day 5 (180,000 per ml). At calving, macrophages were the most prominent cells in buffalo colostrum, followed by lymphocytes and neutrophils. Phagocytic activity was 23% at calving and reduced significantly (P < 0.01) to 14% on day 5. Phagocytic index was highest in the first colostrum, and then decreased non-significantly.

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Promoting Effect of Colostrum on the Phagocytic Activity of Bovine Polymorphonuclear Leukocytes in vitro

Cited by 24 publications

References 19 publications

Effect of β-hydroxybutyric acid, parity, and body condition score on phenotype and proliferative capacity of colostral mononuclear leukocytes of high-yielding dairy cows

Effect of β-hydroxybutyric acid, parity, and body condition score on phenotype and proliferative capacity of colostral mononuclear leukocytes of high-yielding dairy cows

Immunomodulatory effects of ovine serum immunoglobulin in the growing rat

Changes in colostrum of Murrah buffaloes after calving

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