Promoting exercise for patients with multiple myeloma: attitudes and practices of clinical haematologists

Nicol, Jennifer; Hill, Michelle M.; Burton, Nicola W.; Skinner, Tina L.

doi:10.1007/s11764-021-01062-2

Cited by 8 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5][6][7][8][9][10][11][12][13] Even though the benefits of regular exercise have been demonstrated in-depth and patients frequently express interest in structured exercise programs, confidence in recommending physical activity is greatly reduced once bone lesions have occurred. 14 There are only a limited number of studies available on physical exercise in cancer patients with bone metastases in general and even less on patients with unstable bone lesions specifically. 15 Multiple myeloma is a disease characterized by monoclonal expansion of plasma cells in the bone marrow which often causes harmful osteolytic bone lesions in patients.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, disease‐related or therapy‐associated side effects, such as cancer‐related fatigue, peripheral neuropathy or cardiotoxicity can be alleviated by physical exercise 5–13 . Even though the benefits of regular exercise have been demonstrated in‐depth and patients frequently express interest in structured exercise programs, confidence in recommending physical activity is greatly reduced once bone lesions have occurred 14 . There are only a limited number of studies available on physical exercise in cancer patients with bone metastases in general and even less on patients with unstable bone lesions specifically 15 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A precision‐based exercise program for patients with multiple myeloma

Dapunt,

Ehret,

Paratte

et al. 2023

European J of Haematology

View full text Add to dashboard Cite

ObjectivesAim of this study was to retrospectively evaluate an interdisciplinary consultation followed by a precision‐based exercise program (PEP) for myeloma patients with stable and unstable bone lesions.MethodsData of myeloma patients (n = 100) who received a PEP according to an orthopedic evaluation were analyzed. Bone stability was assessed by established scoring systems (Spinal Instability Neoplastic Score [SINS], Mirels' score). All patients with stable and unstable osteolyses received a PEP and n = 91 were contacted for a follow‐up interview.ResultsIn 60% of patients at least one osteolysis of the spine was considered potentially unstable or unstable. Following consultation, the number of patients performing resistance training could be significantly increased (≥2 sessions/week, 55%). Musculoskeletal pain was reported frequently. At the follow‐up interview, 75% of patients who performed PEP stated that painful symptoms could be effectively alleviated by exercise. Moreover, only patients who exercised regularly discontinued pain medication. No injuries were reported in association with PEP.ConclusionWe were able to demonstrate that individualized resistance training is implementable and safe for myeloma patients. By means of a PEP, patients' self‐efficacy in managing musculoskeletal pain was enhanced and pain medication could be reduced.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A precision‐based exercise program for patients with multiple myeloma

Dapunt,

Ehret,

Paratte

et al. 2023

European J of Haematology

View full text Add to dashboard Cite

show abstract

“…Exercising in the presence of bone lesions has been identified as a major safety concern by hematologists [ 24 ] and patients [ 25 ] alike, particularly during resistance training and impact loading activities. Bone involvement occurs more frequently in MM than in any other cancer [ 26 ], with up to 85% of patients with MM developing lytic lesions during the course of their disease [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

An Individualized Exercise Intervention for People with Multiple Myeloma—Study Protocol of a Randomized Waitlist-Controlled Trial

et al. 2022

Self Cite

View full text Add to dashboard Cite

People with multiple myeloma (MM) are second only to people with lung cancer for the poorest reported health-related quality of life (HRQoL) of all cancer types. Whether exercise can improve HRQoL in MM, where bone pain and lesions are common, requires investigation. This trial aims to evaluate the efficacy of an exercise intervention compared with control on HRQoL in people with MM. Following baseline testing, people with MM (n = 60) will be randomized to an exercise (EX) or waitlist control (WT) group. EX will complete 12-weeks of supervised (24 sessions) and unsupervised (12 sessions) individualized, modular multimodal exercise training. From weeks 12–52, EX continue unsupervised training thrice weekly, with one optional supervised group-based session weekly from weeks 12–24. The WT will be asked to maintain their current activity levels for the first 12-weeks, before completing the same protocol as EX for the following 52 weeks. Primary (patient-reported HRQoL) and secondary (bone health and pain, fatigue, cardiorespiratory fitness, muscle strength, body composition, disease response, and blood biomarkers) outcomes will be assessed at baseline, 12-, 24- and 52-weeks. Adverse events, attendance, and adherence will be recorded and cost-effectiveness analysis performed. The findings will inform whether exercise should be included as part of standard myeloma care to improve the health of this unique population.

show abstract

“…Historically, MM doctors have been hesitant to recommend PA to their patients for these reasons, but recent evidence suggests that MM patients can safely perform PA (10), which is associated with better quality-of-life measures, including reduced fatigue and better treatment tolerance (11,12). Despite this change in perspective on the risks and benefits of PA in MM patients, most clinicians still avoid advising specific exercises or proactively recommending exercise professionals to their patients (13).…”

mentioning

confidence: 99%

Physical Activity and Patient-Reported Outcomes in Monoclonal Plasma Cell Disorders

Joseph

Hillengaß

Sweeney

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

Introduction Plasma cell disorders (PCD) are a group of conditions characterized by disproportionate proliferation of a single clone of B lymphocytes. Multiple myeloma (MM) is a malignant type of PCD. Improvements in MM survival have led patients and physicians to pursue strategies to improve quality of life for those living longer with this disease. Bone disease and instability associated with MM have made physicians reluctant to recommend physical activity (PA) to this patient population. The goal of this study was to examine the relationship between PA and physical and psychosocial patient-reported outcomes (PRO) in patients with MM and precursor conditions. Methods We employed a cross-sectional study design. Questionnaires on PA, demographics, fatigue, distress, and other aspects of quality of life were posted on the HealthTree® Cure Hub website, a patient portal through which individuals with MM and related disorders obtain support, track labs and other information about their diseases, and participate in research. Results A total of 794 individuals, including 664 with MM, are included in the current analysis. We observed potential inverse associations between PA and poor quality of life, including problems with sleep, fatigue, neuropathy, distress, and several psychosocial states. On average, patients reported that their PA levels have declined since diagnosis and that they would like to be even more active in the future than they were prior to their diagnosis. Conclusions In our cross-sectional study, regular physical activity was associated with multiple quality-of-life indicators and other PROs, including better sleep and less fatigue, neuropathy, and distress. The findings of this study can help guide the design of prospective studies of the role of PA in MM survivorship.

show abstract

Promoting exercise for patients with multiple myeloma: attitudes and practices of clinical haematologists

Cited by 8 publications

References 24 publications

A precision‐based exercise program for patients with multiple myeloma

A precision‐based exercise program for patients with multiple myeloma

An Individualized Exercise Intervention for People with Multiple Myeloma—Study Protocol of a Randomized Waitlist-Controlled Trial

Physical Activity and Patient-Reported Outcomes in Monoclonal Plasma Cell Disorders

Contact Info

Product

Resources

About