Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors

Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets

“…However, BPA significantly attenuated cell viability from the dose of 2 . 5 mg/l, which is similar to a previous study demonstrating that 10 mg/l BPA exposure can affect the viability of b-cells (Adachi et al 2005). Estrogen administration in rodents can induce islet hypertrophy, which may be crucial in the development of diabetes (Rosmalen et al 2001).…”

“…More importantly, recent studies in rodents suggest that endocrine pancreas is the target of some phenolic estrogens (Alonso-Magdalena et al 2011). For example, long-term exposure to BPA or E 2 (between 100 and 1 nM) has been reported to disrupt pancreatic insulin gene expression, insulin content, and secretion in isolated mice islets (Adachi et al 2005, Alonso-Magdalena et al 2008. The stimulation of insulin release under both hypoglycemic and hyperglycemic conditions was also observed in beta TC-6 cells treated with 100 mg/l BPA (Makaji et al 2011).…”

“…These data are consistent with a previous report that exposure to BPA or NP for 24 h significantly changes insulin secretion in isolated rat islets with 16 . 7 mM glucose stimulation (Adachi et al 2005). For BPA, NP, and OP with lower estrogen activity, the relationship between the doses and insulin secretion was an inverted U-shape, namely increased at first and then declined.…”

“…The stimulation of insulin release under both hypoglycemic and hyperglycemic conditions was also observed in beta TC-6 cells treated with 100 mg/l BPA (Makaji et al 2011). In addition to BPA and E 2 , long-term exposure to nonylphenol (NP) has been confirmed to increase insulin secretion via cytosolic/nuclear estrogen receptors (Adachi et al 2005).…”

Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice

“…Based on others experiments, it was decided to examine 100 µg/kg/day of BPA (Sigma Aldrich Company, Germany) (15)(16)(17) and according to our results in dose response experiment on insulin secretion of isolated islet, at in vitro condition, choose 4 nmol/kg/day of exendin-4. The solvent of BPA was ethyl alcohol with a final concentration of 0.1% and solvent of exendin-4 was distilled water.…”