Background: In order to prevent oral diseases, the use of appropriate educational methods at childhood is one of the most important strategies for the public health. Therefore, the present study aimed to evaluate the effect of training through animations and games on oral health self-efficacy and self-care behaviors among 6-12-aged students. Methods: In this interventional study, 82 students were selected based on cluster random sampling including 38 for the case and 44 for control group). The case group received four sessions of combined learning per week including animations and games while the control group received routine school education. The data were collected in six domains including demographics, self-care, knowledge, attitude, behavior and self-efficacy before and 5 months after the intervention using a questionnaire. SPSS version 20 was used for data analysis.Results: Five months after the intervention, the mean score of self-care, self-efficacy, behavior increased from 3.8 to 4.8, 36.8 to 48.9, and 17.07 to 18.29, respectively indicating a significant change (p < 0.05). However, no significant change was reported in these variables in the control group (p >0.05)Conclusion: The use of combined methods for oral health self-care education can positively influence the students' performance and self-efficacy