Promoting recovery from ischemic stroke

Schmidt, Antje; Minnerup, Jens

doi:10.1586/14737175.2016.1134324

Cited by 25 publications

(10 citation statements)

References 129 publications

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“…It is now widely believed that several days after the onset of stroke is an appropriate time window for cell transplantation therapy. Based on the understanding of the time course of excitotoxicity, brain edema, inflammatory reaction, and trophic factor expressions, we and many others have typically transplanted cells at 7 days after stroke, at which point the extracellular glutamate has returned to lower levels, brain edema subsided, and the microenvironment in the post-stroke brain has entered into a pro-regeneration stage (Schmidt and Minnerup, 2016). Coincidentally, reported clinical trials with autologous MSCs have been limited by the time needed to expand cells to the point that an appropriate cell numbers are available, which normally takes several days or longer (Honmou et al , 2011; Lee et al , 2010).…”

Section: Timing Of Stem Cell Transplantationmentioning

confidence: 99%

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

Wei

Jiang

et al. 2017

Progress in Neurobiology

127

117

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One of the exciting advances in modern medicine and life science is cell-based neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The progress in stem cell biology and creation of adult induced pluripotent stem (iPS) cells has significantly improved basic and pre-clinical research in disease mechanisms and generated enthusiasm for potential applications in the treatment of central nervous system (CNS) diseases including stroke. Endogenous neural stem cells and cultured stem cells are capable of self-renewal and give rise to virtually all types of cells essential for the makeup of neuronal structures. Meanwhile, stem cells and neural progenitor cells are well-known for their potential for trophic support after transplantation into the ischemic brain. Thus, stem cell-based therapies provide an attractive future for protecting and repairing damaged brain tissues after injury and in various disease states. Moreover, basic research on naïve and differentiated stem cells including iPS cells has markedly improved our understanding of cellular and molecular mechanisms of neurological disorders, and provides a platform for the discovery of novel drug targets. The latest advances indicate that combinatorial approaches using cell based therapy with additional treatments such as protective reagents, preconditioning strategies and rehabilitation therapy can significantly improve therapeutic benefits. In this review, we will discuss the characteristics of cell therapy in different ischemic models and the application of stem cells and progenitor cells as regenerative medicine for the treatment of stroke.

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Section: Timing Of Stem Cell Transplantationmentioning

confidence: 99%

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

Wei

Jiang

et al. 2017

Progress in Neurobiology

127

117

View full text Add to dashboard Cite

show abstract

“…In some trials, neural stem cell (NSCs) transplantation was used to treat stroke, and it was found that when the transplantation was conducted on the second day after onset, the number of surviving cells was greater compared with the transplantation done in the sixth week [ 111 ]. Taking into account the excitotoxicity, brain edema, inflammatory response, and the expression of nutritional factors and other factors, most researchers believe that 7 days after the onset of stroke is a better time for transplantation, because at this time the brain microenvironment has entered the stage of promoting regeneration [ 112 ].…”

Section: Applicationmentioning

confidence: 99%

Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application

Liao

Luo

Cao

et al. 2017

Stem Cells International

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Ischemic stroke is one of the leading causes of human death and disability worldwide. So far, ultra-early thrombolytic therapy is the most effective treatment. However, most patients still live with varying degrees of neurological dysfunction due to its narrow therapeutic time window. It has been confirmed in many studies that endothelial progenitor cells (EPCs), as a kind of adult stem cells, can protect the neurovascular unit by repairing the vascular endothelium and its secretory function, which contribute to the recovery of neurological function after an ischemic stroke. This paper reviews the basic researches and clinical trials of EPCs especially in the field of ischemic stroke and addresses the combination of EPC application with new technologies, including neurovascular intervention, synthetic particles, cytokines, and EPC modification, with the aim of shedding some light on the application of EPCs in treating ischemic stroke in the future.

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“…The receptor for EPO is abundantly present within both central and peripheral nervous systems and plays a role in neural degenerative diseases by attenuating hypoxic insults [ 76 , 77 ]. Recombinant EPO has been successfully used in clinical trials to improve neurologic function following ischemic stroke in humans [ 78 , 79 ]. The neurotrophic properties of EPO make its use particularly attractive for CNI models of ED.…”

Section: New Molecular Targets For Neurogenic Edmentioning

confidence: 99%

Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury

Campbell¹,

Burnett²

2017

IJMS

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Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than 50% of patients, regardless of additional patient factors. ED related to CNI is difficult to treat and typically poorly responsive to first- and second-line therapeutic options. Recently, a significant amount of research has been devoted to exploring neuroprotective and neuroregenerative approaches to salvage erectile function in patients with CNI. In addition, therapeutic options such as neuregulins, immunophilin ligands, gene therapy, stem cell therapy and novel surgical strategies, have shown benefit in pre-clinical, and limited clinical studies. In the era of personalized medicine, these new therapeutic technologies will be the future of ED treatment and are described in this review.

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Promoting recovery from ischemic stroke

Cited by 25 publications

References 129 publications

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application

Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury

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