2022
DOI: 10.21037/atm-22-3956
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Promoting repair of highly purified stromal vascular fraction gel combined with advanced platelet-rich fibrin extract for irradiated skin and soft tissue injury

Abstract: Background To evaluate the effect of highly purified stromal vascular fraction gel (SVFG) combined with advanced platelet-rich fibrin extract (APRFE) in treatment of irradiated skin and soft tissue injury. Methods The subcutaneous fat and whole blood of 4 rabbits were collected to isolate the SVFG and APRFE, respectively. Forty-eight rabbits were divided into 4 groups to prepare irradiated skin injury models with 25 Gy for 24 hours; corresponding dose were performed sub… Show more

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Cited by 4 publications
(3 citation statements)
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“…A decrease in the density of microvessels in the skin, leading to tissue ischemia and, thereby, significantly reducing the rate of wound healing after 25 Gy X-irradiation was found in another study. In addition, the authors noted an increase in the expression of pro-inflammatory cytokines (TNF-α, IL-1, and IL-6), the release of cell adhesion molecules, which accelerated the migration, adhesion, and exudation of leukocytes and induced the migration of macrophages, neutrophils, and monocytes, which leads to a local inflammatory response to radiation injury ( Li et al , 2022 ). The polymorphonuclear infiltration of the skin found at various doses of single local electron irradiation can be explained by a similar mechanism the development of inflammation, the key role which is played by the imbalance of pro-inflammatory and anti-inflammatory cytokines.…”
Section: Discussionmentioning
confidence: 99%
“…A decrease in the density of microvessels in the skin, leading to tissue ischemia and, thereby, significantly reducing the rate of wound healing after 25 Gy X-irradiation was found in another study. In addition, the authors noted an increase in the expression of pro-inflammatory cytokines (TNF-α, IL-1, and IL-6), the release of cell adhesion molecules, which accelerated the migration, adhesion, and exudation of leukocytes and induced the migration of macrophages, neutrophils, and monocytes, which leads to a local inflammatory response to radiation injury ( Li et al , 2022 ). The polymorphonuclear infiltration of the skin found at various doses of single local electron irradiation can be explained by a similar mechanism the development of inflammation, the key role which is played by the imbalance of pro-inflammatory and anti-inflammatory cytokines.…”
Section: Discussionmentioning
confidence: 99%
“…A decrease in the density of microvessels in the skin, leading to tissue ischemia and, thereby, significantly reducing the rate of wound healing after 25 Gy X-irradiation was found in another study. In addition, the authors noted an increase in the expression of pro-inflammatory cytokines (TNF-α, IL-1 and IL-6), the release of cell adhesion molecules, which accelerated the migration, adhesion and exudation of leukocytes and induced the migration of macrophages, neutrophils and monocytes, which leads to a local inflammatory response to radiation injury [26]. The polymorphonuclear infiltration of the skin found at various doses of single local electron irradiation can be explained by a similar mechanism the development of inflammation, the key role in which is played by the imbalance of pro-inflammatory and anti-inflammatory cytokines.…”
Section: Discussionmentioning
confidence: 99%
“…В другом исследовании, после воздействия рентгеновского излучения в дозе 25 Гр было обнаружено уменьшение плотности микрососудов в коже, приводящее к ишемии тканей и, тем самым, значительно снижающее скорость заживления ран. Кроме того, авторы отмечали увеличение экспрессии провоспалительных факторов (TNF-α, IL-1 и IL-6) высвобождение молекул клеточной адгезии, что ускоряло миграцию, адгезию и экссудацию лейкоцитов и индуцировало миграцию макрофагов, нейтрофилов и моноцитов, как клеточного субстрата местной воспалительной реакции в ответ на лучевое поражение [18]. Вероятно, обнаруженная полиморфно-клеточная инфильтрация кожи при различных дозах облучения электронами может быть объяснена механизмом развития воспаления.…”
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