People with disability (PWD) became significant issue in development, hence local government in Indonesia try to accommodate in their program. Unfortunately, most PWD empowerments are performed by government through a conventional program. This article describes the implementation of entrepreneurship approach on PWD empowerment in Resapombo Village, Blitar District Indonesia. A qualitative approach was employed by researchers to explore the innovativeness of PWD empowerment program, to identify the opportunities and the challenges for the development. This study found that new issue in academic field, development for social entrepreneurship study, and public-private partnership-based initiatives are the opportunities of entrepreneurship approach on PWD empowerment, while changing people perception about PWD, limited financial support, and low level reward for social workers are identified as challenges of this program. The study provides recommendations for government to invites more social stakeholders to participate in PWD empowerment and providing incentives. This study also provides opportunities for the scholars to examine and to develop new conceptual model in PWD empowerment, specifically on entrepreneurship approach for PWD.