Promoting whole person health: Exploring the role of traditional Chinese medicine in Polish healthcare

Rybicka, Monika; Zhao, Jing; Piotrowicz, Karolina; Ptasnik, Sara; Mitka, Kamila; Kocot-Kępska, Magdalena; Hui, Ka-Kit

doi:10.1016/j.joim.2023.10.001

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…In MyD88 - or CARD11 -mutant B-cell lymphomas, senescent tumour cells express high levels of PD-L1, thus mediating age-related immune evasion ( 95 ). In recent years, PD-1 inhibitors have been used to treat various relapsed or refractory lymphomas, such as R/R cHL ( 135 ) and R/R follicular lymphoma ( 136 ). However, PD-1 inhibitors targeting senescent lymphoma cells have not been studied in clinical trials.…”

Section: Treatment Strategies For Senescence-mediated Lymphoma Resist...mentioning

confidence: 99%

Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)

Zhang,

Chu,

Hou

et al. 2024

Int J Oncol

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Cellular senescence has a complex role in lymphocyte carcinogenesis and drug resistance of lymphomas. Senescent lymphoma cells combine with immunocytes to create an ageing environment that can be reprogrammed with a senescence-associated secretory phenotype, which gradually promotes therapeutic resistance. Certain signalling pathways, such as the NF-κB, Wnt and PI3K/AKT/mTOR pathways, regulate the tumour ageing microenvironment and induce the proliferation and progression of lymphoma cells. Therefore, targeting senescence-related enzymes or their signal transduction pathways may overcome radiotherapy or chemotherapy resistance and enhance the efficacy of relapsed/refractory lymphoma treatments. Mechanisms underlying drug resistance in lymphomas are complex. The ageing microenvironment is a novel factor that contributes to drug resistance in lymphomas. In terms of clinical translation, some senolytics have been used in clinical trials on patients with relapsed or refractory lymphoma. Combining immunotherapy with epigenetic drugs may achieve better therapeutic effects; however, senescent cells exhibit considerable heterogeneity and lymphoma has several subtypes. Extensive research is necessary to achieve the practical application of senolytics in relapsed or refractory lymphomas. This review summarises the mechanisms of senescence-associated drug resistance in lymphoma, as well as emerging strategies using senolytics, to overcome therapeutic resistance in lymphoma.

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Section: Treatment Strategies For Senescence-mediated Lymphoma Resist...mentioning

confidence: 99%

Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)

Zhang,

Chu,

Hou

et al. 2024

Int J Oncol

View full text Add to dashboard Cite

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Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives

Zhang,

Dong,

Zhu

et al. 2024

Nanotechnology Reviews

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Childhood rhinitis is an inflammatory condition affecting the nasal mucosa of children worldwide. The physical, social, and cognitive performance of children is affected by the chronic symptoms of childhood rhinitis. Effective treatment is essential to avoid long-term effects on children’s lifestyles and well-being. Traditional Chinese medicine (TCM) has been used to treat and prevent several illnesses, and it plays a crucial role in healthcare and rehabilitation. TCM has traditionally been used to holistically treat rhinitis. However, the drawbacks of TCMs, such as their poor water solubility, low bioavailability, single-use, and poor targeting ability, severely restrict their use. In recent years, nanotechnology has been used for various drugs to improve their therapeutic effectiveness and reduce their associated adverse effects. Nanomaterials for TCM formulations are synthesized to be compatible with herbal extracts and sustain active component therapeutic qualities. Nanocarrier-based drug delivery improves bioavailability, circulation time, and targeted distribution, resolving TCM administration issues. This review assesses the innovative combination of TCM and nanotechnology developments for the treatment of childhood rhinitis, providing insights into novel therapeutic approaches. This review also provides significant insights into the potential of this multidisciplinary approach to transform treatment techniques in childhood rhinitis and offers a road map for future research initiatives in this promising sector.

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Promoting whole person health: Exploring the role of traditional Chinese medicine in Polish healthcare

Cited by 2 publications

References 35 publications

Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)

Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)

Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives

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