Promotion by Collagen Tripeptide of Type I Collagen Gene Expression in Human Osteoblastic Cells and Fracture Healing of Rat Femur

Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate

“…Recent human studies have suggested that daily ingestion of collagen hydrolysate increases the moisture content on the epidermis of women during winter, and also moderates joint pain in subjects with knee osteoarthritis (Deal & Moskowitz, 1999;Matsumoto, Ohara, Itoh, Nakamura, & Takahashi, 2006). In addition, several animal experiments support the beneficial effects of ingestion of collagen hydrolysate on skin and joint conditions (Moskowitz, 2000;Oesser, Adam, Babel, & Seifert, 1999;Tanaka, Koyama, & Nomura, 2009;Tsuruoka, Yamato, Sakai, Yoshitake, & Yonekura, 2007;Wu, Fujioka, Sugimoto, Mu, & Ishimi, 2004). After ingestion of collagen hydrolysate, Pro-Hyp, Pro-Hyp-Gly, Ala-Hyp, Ala-Hyp-Gly, Ser-Hyp, Ser-Hyp-Gly, Leu-Hyp, Ile-Hyp and Phe-Hyp have been identified as food-derived collagen peptides in human blood.…”

Effects of oral administration of tripeptides derived from type I collagen (collagen tripeptide) on atherosclerosis development in hypercholesterolemic rabbits

“…The tripeptide components (Gly-X-Y) of Ctp promote collagen production by human osteoblasts (13) and fibroblasts (14). However, the component(s) of Ctp that mitigates atherosclerosis is unknown.…”

“…For example, Ctp apparently accelerates the healing of bone fractures (12), stimulates the calcification of human osteoblastic cells (13), and increases the production of type I collagen by human osteoblastic cells (13). DNA microarray and quantitative RT-PCR analyses demonstrate that Ctp up-regulates osterix, which is a bone-specific transcription factor (13).…”

Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model

“…Recently, collagen and collagen peptides, including CTP, have been implicated as functional foods with several biological effects. For example, CTP exerted beneficial effects on bone fracture healing in experimental animal models [9,10]. Compared with vehicle treatment, oral administration of collagen peptides produced faster wound healing and tissue regeneration, better angiogenesis, and helped to form thicker and betterorganized collagen fiber deposition [10].…”