Promotion of collagen mineralization and dentin repair by succinates

Jin, Wenjing; Jin, Yeli; Duan, Pengqiang; Wu, Huaiqing; Zhang, Leiqing; Du, Qiaolin; Pan, Haihua; Tang, Ruikang; Shao, Changyu

doi:10.1039/d2tb01005d

Cited by 15 publications

(15 citation statements)

References 44 publications

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“…Moreover, the SA pre-treated demineralized dentin promoted dentin remineralization. The mechanical properties of the remineralized dentin were similar to natural dentin (Jin et al, 2022). Earlier efforts to synthesize OCP incorporated with SA have been commenced by Marković et al (1994).…”

Section: Succinatementioning

confidence: 79%

Role of carboxylic organic molecules in interfibrillar collagen mineralization

Indurkar

Choudhary

Rubenis

et al. 2023

Front. Bioeng. Biotechnol.

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Bone is a composite material made up of inorganic and organic counterparts. Most of the inorganic counterpart accounts for calcium phosphate (CaP) whereas the major organic part is composed of collagen. The interfibrillar mineralization of collagen is an important step in the biomineralization of bone and tooth. Studies have shown that synthetic CaP undergoes auto-transformation to apatite nanocrystals before entering the gap zone of collagen. Also, the synthetic amorphous calcium phosphate/collagen combination alone is not capable of initiating apatite nucleation rapidly. Therefore, it was understood that there is the presence of a nucleation catalyst obstructing the auto-transformation of CaP before entering the collagen gap zone and initiating rapid nucleation after entering the collagen gap zone. Therefore, studies were focused on finding the nucleation catalyst responsible for the regulation of interfibrillar collagen mineralization. Organic macromolecules and low-molecular-weight carboxylic compounds are predominantly present in the bone and tooth. These organic compounds can interact with both apatite and collagen. Adsorption of the organic compounds on the apatite nanocrystal governs the nucleation, crystal growth, lattice orientation, particle size, and distribution. Additionally, they prevent the auto-transformation of CaP into apatite before entering the interfibrillar compartment of the collagen fibril. Therefore, many carboxylic organic compounds have been utilized in developing CaP. In this review, we have covered different carboxylate organic compounds governing collagen interfibrillar mineralization.

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Section: Succinatementioning

confidence: 79%

Role of carboxylic organic molecules in interfibrillar collagen mineralization

Indurkar

Choudhary

Rubenis

et al. 2023

Front. Bioeng. Biotechnol.

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“…In the teeth and hard bone tissues, existing small biomolecules (e.g., citrate and succinate) and biopolymers (e.g., chondroitin sulfate) have been observed to bind to collagen fibers, which improve collagen biomineralization or collagen mineralization [ 31 , 32 ]. In dentin, succinic acid has been reported to promote the remineralization of dentin [ 33 ]. SA has been studied as a bioactive biomolecule that can be used for calcium mineral growth control and hard tissue repair.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Root Caries Using Oxalic Acid

et al. 2023

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Certain dentin hypersensitivity treatment materials include oxalic acid to coat dentin surfaces with minerals, while certain organic acids possess a remineralization effect. Herein, an organic acid that inhibits the demineralization and coating of root surfaces was evaluated. Specimens were produced using five non-carious extracted bovines. Four different acids were used: oxalic acid (OA), malonic acid (MA), polyacrylic acid (PA), and succinic acid (SA). Each acid was applied to the root surface and washed using distilled water or a remineralization solution, and the surface was observed using scanning electron microscopy (SEM). All the surfaces of each specimen, barring the polished surface, were covered with wax and immersed in an automatic pH cycling system for two weeks. Dentin demineralization was analyzed using transverse microradiography (TMR) before and after pH cycling. SEM analysis demonstrated that the three acid groups demineralized the dentin surface, whereas the OA group generated crystals covering the dentin surface, even in a distilled water environment. TMR analysis revealed that the OA groups showed significantly lower integrated mineral loss compared with the other groups, even in the distilled water environment. The results suggest that OA generates insoluble calcium oxalate crystals on the dentin and suppresses demineralization even under low saliva conditions.

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“…The FTIR spectra of the collagen gel and CYP-coated collagen gel were obtained by ATR-FTIR analysis (Nicolet i50; Thermo Scientific, USA). 28,29…”

Section: Methodsmentioning

confidence: 99%