Promotion of IgA Immune Response in Patients with Crohn&amp;rsquo;s Disease by Oral Bacteriotherapy with &lt;i&gt;Lactobacillus GG&lt;/i&gt;

Malin, Merja; Suomalainen, Hanna; Saxelin, Maija; Isolauri, Erika

doi:10.1159/000177907

Cited by 264 publications

(142 citation statements)

References 24 publications

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“…The two strains successfully inhibited IL-8 secretion and NF-κB activation in intestinal epithelia in the experiment. At present, some probiotic compounds have been used in management of some diseases, such as maintenance therapy in IBD [17,18] . Although the mechanism of probiotic action has not been fully understood, the beneficial effects were consistent with an anti-inflammatory state conferred by probiotics [19,20] .…”

Section: Discussionmentioning

confidence: 99%

Probiotics inhibit TNF-α-induced interleukin-8 secretion of HT29 cells

Bai¹,

Ouyang²,

Wen³

et al. 2004

WJG

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AIM:To study the effect of probiotics on interleukin-8 secretion in intestinal epithelia when stimulated by proinflammatory cytokines. METHODS:Colonic adenocarcinoma HT29 cells were cultured and divided into four groups: control, TNF-α (group T in short), bifidobacterium (group B), lactobacillus (group L). B. Longum and L. bulgaricus were suspended in culture medium with a concentration of 1×10 8 cfu/ml and added into 24 wells respectively. One hour later TNF-α (10 ng/ml) was added into each well of groups T, B, L. The supernatants were collected and measured for IL-8 after 3 hours, nuclear factor-κB (NF-κB) p65 was also examined by Western blotting. RESULTS:

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Section: Discussionmentioning

confidence: 99%

Probiotics inhibit TNF-α-induced interleukin-8 secretion of HT29 cells

Bai¹,

Ouyang²,

Wen³

et al. 2004

WJG

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“…Duchmann et al (1995) have previously demonstrated that healthy individuals are tolerant to their own microbiota, and that such tolerance is disturbed in patients with inflammatory bowel disease. Altered gut microbiota is reported in patients with rheumatoid arthritis (Malin et al, 1996) and allergic disease (Björkstén et al, 1999(Björkstén et al, , 2001Kalliomäki et al, 2001a;Kirjavainen et al, 2002), indicating that the normal gut microbiota constitutes an ecosystem responding to and regulating inflammation both in the gut and elsewhere in the body.…”

Section: Aberrations In Intestinal Microbiotamentioning

confidence: 99%

“…In the probiotic group, the corresponding figure was 3/20, which suggests that oral administration of the probiotic mixture was effective in preventing flare-ups of chronic pouchitis. Malin et al (1996) assessed the immunostimulatory effect of L. rhamnosus GG (daily dose 2 Â 10 10 CFU for 10 days) on 14 children with Crohn's disease. L. rhamnosus GG was shown to stimulate the gut IgA immune response and the authors concluded that L. rhamnosus GG could have potential in promoting the gut immunological barrier in Crohn's disease.…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

Gut bacteria and health foods—the European perspective

Saarela

Lähteenmäki

Crittenden

et al. 2002

International Journal of Food Microbiology

259

139

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Probiotics, prebiotics, and synbiotics aimed at improving intestinal health currently represent the largest segment of the functional foods market in Europe, Japan and Australia. Evidence continues to emerge demonstrating that these ingredients have the potential to improve human health in specific intestinal disorders. The European Commission, through its 5th Framework Programme, is presently focusing on a substantial effort in the science of the intestinal microbiota, its interaction with its host and methods to manipulate its composition and activity for the improvement of human health and well being. Eight multicentre and multidisciplinary research projects now cover a range of topics required for the development of efficacious probiotic foods, from understanding probiotic mechanisms at a molecular level; developing technologies to ensure delivery of stable products; and demonstrating safety and efficacy of specific probiotics in defined treatment targets. This concerted research effort promises to provide us with an enhanced understanding of the human intestinal microbiota's role in health and disease, and new approaches and products to tackle a variety of intestinal problems. D

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“…LGG increases anti-inflammatory IL-10 levels in children (7). Furthermore, LGG has been suggested as adjunctive therapy for Crohn's disease (17).…”

mentioning

confidence: 99%

Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells

Yan

Polk

2002

Journal of Biological Chemistry

484

334

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Probiotic bacteria are microorganisms that benefit the host by preventing or ameliorating disease. However, little information is known regarding the scientific rationale for using probiotics as alternative medicine. The purpose of this paper is to investigate the mechanisms of probiotic beneficial effects on intestinal cell homeostasis. We now report that one such probiotic, Lactobacillus rhamnosus GG (LGG), prevents cytokineinduced apoptosis in two different intestinal epithelial cell models. Culture of LGG with either mouse or human colon cells activates the anti-apoptotic Akt/protein kinase B. This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen-activated protein kinase by tumor necrosis factor, interleukin-1␣, or ␥-interferon. Furthermore, products recovered from LGG culture broth supernatant show concentration-dependent activation of Akt and inhibition of cytokine-induced apoptosis. These observations suggest a novel mechanism of communication between probiotic microorganisms and epithelia that increases survival of intestinal cells normally found in an environment of pro-apoptotic cytokines.

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Promotion of IgA Immune Response in Patients with Crohn’s Disease by Oral Bacteriotherapy with <i>Lactobacillus GG</i>

Cited by 264 publications

References 24 publications

Probiotics inhibit TNF-α-induced interleukin-8 secretion of HT29 cells

Probiotics inhibit TNF-α-induced interleukin-8 secretion of HT29 cells

Gut bacteria and health foods—the European perspective

Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells

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