Promotion of osteoblastic Ca2+ accumulation by Eucommia leaf extract

Oikawa, Hirotaka; Miyazaki, Shouhei; Nishida, Keigo; Zhang, Wenping; Hirata, Toshifumi; Hosoo, Shingo; Yamaguchi, Yoshihiro; Yamasaki, Hidemasa; Nishibe, Sansei; Fujikawa, Takahiko

doi:10.15761/gdt.1000s2002

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…As the most abundant metal element in the body, calcium is widely involved in various physiological processes such as muscle contraction, neurotransmitter synthesis and release [52], and it is also closely related to the muscle ber development [52], muscle ber type [53] and muscle hardness [54]. In the study of Oikawa et al [55], ELE was reported to promote calcium accumulation in human osteoblasts through calcium signaling pathways. Therefore, the increased calcium content in esh by dietary ELE was also found in the present study.…”

Section: Effects Of Eucommia Extracts On the Esh Qualitymentioning

confidence: 99%

Influences of dietary Eucommia ulmoides extract on growth, flesh quality, antioxidant capacity and collagen-related genes expression in grass carp (Ctenopharyngodon idellus)

Yang

et al. 2021

Animal Feed Science and Technology

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Background: The study investigated the effects of dietary Eucommia ulmoides extracts on growth, esh quality and collagen-related genes expression of grass carp (Ctenopharyngodon idella). Eucommia ulmoides bark extract (EBE) and Eucommia ulmoides leaf extract (ELE) were individually supplemented into basal diet (control) at an inclusion of 4 g/kg, and then the three diets were fed to grass carp (59.7 ± 0.3g) for 60 days.Results: The results indicated that dietary ELE signi cantly increased weight gain (+4.22%), and decreased feed conversion ratio (-0.07) (P<0.05), while EBE did not signi cantly affect the growth performance of grass carp. Compared to the control, dietary ELE increased apparent digestibility coe cient of dry matter, crude protein and intestinal digestive enzyme activity (P<0.05), and the contents of calcium, total collagen, heat-insoluble collagen and free amino acids level (including delicious amino acids) in esh were also increased (P<0.05). In both extracts groups, the esh centrifugal loss, steaming loss, drip loss 24h , protein carbonyl and malondialdehyde were signi cantly lower, and superoxide dismutase and glutathione peroxidase activities were higher than the control (P<0.05). No signi cant differences in the amount of saturated, monounsaturated and polyunsaturated fatty acids in esh were found among the three groups, but DPA, DHA, n-3 polyunsaturated fatty acids and n-3/n-6 ratio in esh were increased by dietary EBE and ELE (P<0.05). In collagen-related genes expression, the ELE supplementation signi cantly promoted the expression of collagen type (COL1A1, COL1A2), proline hydroxylase, lysine oxidasein in muscle, while the expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 was decreased (P<0.05). Conclusion:In conclusion, dietary ELE improved the growth, muscle antioxidant capacity and esh quality of grass carp.

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Section: Effects Of Eucommia Extracts On the Esh Qualitymentioning

confidence: 99%

Influences of dietary Eucommia ulmoides extract on growth, flesh quality, antioxidant capacity and collagen-related genes expression in grass carp (Ctenopharyngodon idellus)

Yang

et al. 2021

Animal Feed Science and Technology

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“…Obesity is characterized as hypertrophy and proliferation of adipocytes in white adipose tissue (WAT) [1,2]. Eucommia leaf extract (ELE) has been reported to have various bioactive properties [3][4][5][6][7][8][9][10][11], such as anti-obesity effects [6][7][8][9][10][11]. Asperuloside (ASP) is indicated as the major ingredient of ELE; it contributes to its anti-obesity effect [8,11].…”

Section: Introductionmentioning

confidence: 99%

Chronic administration of Eucommia leaf extract (ELE) and asperuloside(ASP), the major component of ELE, prevents adipocyte hypertrophy in white adipose tissues

Miyazaki¹,

Oikawa²,

Hirata³

et al. 2017

Glob Drugs Therap

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“…In recent years, the study of Eucommia leaf extract (ELE) has been focused on its efficacy in maintaining human health. Reports on the biogenic effectiveness of ELE ingestion have identified the following benefits: 1) antihyperlipidemic effects that reduce visceral fat and suppress elevated levels of triglyceride and cholesterol in the blood [1][2][3][4][5][6][7]; 2) effects on bone, such as preventing the onset of postmenopausal osteoporosis and promoting calcium accumulation in osteoblasts [8][9][10]; 3) antihypertensive effects that slowly decrease blood pressure by maintaining the flexibility of the blood vessels and promoting arterial smooth muscle relaxation [2,11]; 4) rapid eye movement sleep and non-rapid eye movement sleep inducing effect [12]; and 5) preventative effects on ulcerative colitis by asperuloside, one of the major components of ELE [13]. Thus, ELE promotes systemic health.…”

Section: Introductionmentioning

confidence: 99%

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

Oikawa¹,

Miyazaki²,

Nishide³

et al. 2017

Glob Drugs Therap

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IntroductionDu-zhong tea is a common drink ingested for health purposes. The tea is made by roasting the leaves of the Eucommia ulmoides tree. In recent years, the study of Eucommia leaf extract (ELE) has been focused on its efficacy in maintaining human health. Reports on the biogenic effectiveness of ELE ingestion have identified the following benefits: 1) antihyperlipidemic effects that reduce visceral fat and suppress elevated levels of triglyceride and cholesterol in the blood [1][2][3][4][5][6][7]; 2) effects on bone, such as preventing the onset of postmenopausal osteoporosis and promoting calcium accumulation in osteoblasts [8][9][10]; 3) antihypertensive effects that slowly decrease blood pressure by maintaining the flexibility of the blood vessels and promoting arterial smooth muscle relaxation [2,11]; 4) rapid eye movement sleep and non-rapid eye movement sleep inducing effect [12]; and 5) preventative effects on ulcerative colitis by asperuloside, one of the major components of ELE [13]. Thus, ELE promotes systemic health. Among the effects of ELE, many anti-obesity effects have been studied from the viewpoint of preventing lifestyle diseases. Therefore, we proposed that ELE ingestion might prevent the obesity caused by nocturnal eating, as ELE ingestion reduces food intake and water consumption during the light phase (i.e., inactive period) in rats [7,14,15]. On the other hand, it has been reported that appetite suppression due to the inhibition of the parasympathetic nervous system, which controls the gastrointestinal tract, is related to the suppression of feeding and the improvement AbstractEucommia leaf extract (ELE) is known to have a preventive effect on obesity. The effect of ELE partially depends on the inhibition of locomotor activity during inactive periods and indirect inhibition of food and water consumption. Moreover, it has been reported that suppression of the parasympathetic nervous system is involved in appetite suppression and that lipid metabolism is improved by ELE ingestion. However, there is no evidence that food and water consumption during the inactive period occur as a result of regulation of the parasympathetic nervous system. Therefore, in this study, the involvement of the parasympathetic nervous system was examined using water intake during the inactive period of rats as an index. Rats were fed a high-fat diet (35% fat; HFD) or an HFD + ELE 5% diet and were observed for 3 days during which pilocarpine (10 mg/kg/day, intraperitoneally; i.p.) or saline (i.p.; used as a control) was administered daily. When compared with the control group, no effect of pilocarpine was observed in the dark phase (active period) or light phases (inactive period). The slightly increased water consumption of the HFD + ELE 5% group was not affected by the administration of pilocarpine in the active period. However, the markedly decreased amount of water consumption in the inactive period that was due to ELE ingestion was restored to the control level by the administration of pilocarpine. These r...

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Promotion of osteoblastic Ca2+ accumulation by Eucommia leaf extract

Cited by 4 publications

References 45 publications

Influences of dietary Eucommia ulmoides extract on growth, flesh quality, antioxidant capacity and collagen-related genes expression in grass carp (Ctenopharyngodon idellus)

Influences of dietary Eucommia ulmoides extract on growth, flesh quality, antioxidant capacity and collagen-related genes expression in grass carp (Ctenopharyngodon idellus)

Chronic administration of Eucommia leaf extract (ELE) and asperuloside(ASP), the major component of ELE, prevents adipocyte hypertrophy in white adipose tissues

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

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