Promotive effects of resistant maltodextrin on apparent absorption of calcium, magnesium, iron and zinc in rats

Miyazato, Shoko; Nakagawa, Chihiro; Kishimoto, Yuka; Tagami, Hirotaka; Hara, Hiroshi

doi:10.1007/s00394-009-0062-6

Cited by 43 publications

(31 citation statements)

References 17 publications

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“…Resistant maltodextrin (RMD) is a non-viscous soluble dietary fiber having various physiological effects, which were demonstrated by in-vitro, in-vivo and clinical experiments (20)(21)(22)(23). It has been reported that the continuous ingestion of 15-30 g/d of RMD significantly improves glucose and lipid metabolism (24)(25)(26).…”

Section: Improvement Effect Of Resistant Maltodextrin In Humans Withmentioning

confidence: 99%

Improvement Effect of Resistant Maltodextrin in Humans with Metabolic Syndrome by Continuous Administration

Hashizume

Kishimoto

Kanahori

et al. 2012

J Nutr Sci Vitaminol

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Summary Resistant maltodextrin (RMD) is a soluble dietary fiber ingredient whose physiological functions are well recognized in Foods for Specified Health Use (FOSHU) for maintaining healthy intestinal regularity, blood glucose levels, and serum lipids. However, its efficacy on combined health risks-metabolic syndrome-was not studied yet. In this study the efficacy of RMD on humans with metabolic syndrome was investigated. A randomized double-blind placebo-controlled parallel-group trial was conducted. Thirty subjects with metabolic syndrome were randomly allocated into 2 groups and took either tea containing 9 g of RMD (treatment group) or placebo tea at three mealtimes daily for 12 wk. Blood was collected and body fat was scanned periodically. In the RMD treatment group, waist circumference, visceral fat area, fasting blood glucose, HOMA-R and serum triacylglycerol (TG) were significantly decreased compared to baseline, and significant time-by-treatment interaction was observed for waist circumference, visceral fat area, HOMA-R and serum TG (p50.044, p50.012, p50.032, and p50.049, respectively). The change ratio of visceral fat area showed negative statistical correlation with the baseline value (p50.033), suggesting that efficacy of RMD was emphasized in the subjects having a larger visceral fat area. After the 12-wk RMD treatment, the total number of metabolic syndrome risk factors decreased to 20 from 32 with 2 subjects having no risks, while that of the placebo group decreased to 25 from 32. These findings suggest that continuous ingestion of RMD may improve the risk factors of metabolic syndrome by reducing visceral fat and improving glucose and lipid metabolism.

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Section: Improvement Effect Of Resistant Maltodextrin In Humans Withmentioning

confidence: 99%

Improvement Effect of Resistant Maltodextrin in Humans with Metabolic Syndrome by Continuous Administration

Hashizume

Kishimoto

Kanahori

et al. 2012

J Nutr Sci Vitaminol

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“…In addition, our previous study showed that caecal weight was larger in rats fed a combination of dairy product fermented by lactobacilli and GOS than in rats fed the dairy product fermented by lactobacilli or GOS alone, suggesting that dairy product fermented by lactobacilli and GOS additively or synergistically increased caecal fermentation. In the present study, we observed increased caecal weight in the PPI + YG group, indicating increased caecal fermentation [31,32], which could be implicated in the increased calcium absorption. The potential positive effects of low-digestible carbohydrates on calcium absorption in large intestine can be explained by the following mechanisms [33].…”

Section: Discussionmentioning

confidence: 73%

Effects of Proton Pump Inhibitor Administration and Intake of a Combination of Yogurt and Galactooligosaccharides on Bone and Mineral Metabolism in Rats

Takasugi¹,

Shioyama²,

Kitade³

et al. 2016

Nutrients

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The aim of this study was to investigate the effects of proton pump inhibitor (PPI), the most potent acid-suppressing drug, administration and intake of a combination of yogurt and galactooligosaccharides (YG) on bone and mineral metabolism in adult rats. Twelve-week-old male Wistar rats were divided into three groups: a control group fed the control diet with vehicle administration, a PPI group fed the control diet with PPI administration and a YG + PPI group fed the YG diet with PPI administration. All of the groups received their respective experimental diets and daily subcutaneous injection of the vehicle or PPI for 12 weeks. The PPI group showed significantly lower bone mineral density (BMD) of the femur and the lumbar vertebrae and serum fibroblast growth factor 23 (FGF23) and significantly higher phosphorus absorption and serum 1,25-dihydroxyvitamin D (1,25(OH)2D) than the control group, although PPI did not affect calcium absorption. The PPI + YG group showed significantly higher BMD and serum FGF23 and significantly lower phosphorus absorption and serum 1,25(OH)2D than the PPI group. Furthermore, the PPI + YG group showed higher calcium absorption than the control group. These results suggest that although PPI administration did not affect calcium absorption, it adversely affected BMD and influenced phosphorus metabolism in adult rats. Furthermore, the YG diet beneficially affected BMD and attenuated the effects of PPI administration on phosphorus metabolism.

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“…Intestinal regularity is typically influenced by DF, and studies have shown that RMD increases stool frequency and volume in humans [22]. Furthermore, it has been reported that RMD is fermented by the intestinal bacterial flora, including bifidobacteria, resulting in an increase in the types and number of bacteria in the intestinal flora [20, 23–27]. Fermentation by gut bacteria leads to short-chain fatty acid (SCFA) production, mainly: acetate, propionate and butyrate.…”

Section: Introductionmentioning

confidence: 99%

Digestion-resistant maltodextrin effects on colonic transit time and stool weight: a randomized controlled clinical study

et al. 2015

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PurposeIncreased awareness of the importance of dietary fibre has led to increased interest in “functional” fibre components like digestion-resistant maltodextrin (RMD). This randomized, placebo-controlled, double-blind study assessed the effects of RMD in the colonic transit time (CTT) and defecation characteristics (frequency, stool volume and consistency).MethodsSixty-six healthy adult volunteers (32 men) who did not have a daily defecation habit had a 7-day run-in period before the 21-day intervention period with RMD or placebo. CTT and segmental CTT (SCTT) were assessed by a single abdominal X-ray film taken at the end of both periods after radiopaque marker ingestion. Defecation characteristics and intestinal functions were also assessed, which were self-reported by patients. Intragroup comparisons were evaluated by Student’s paired t test, Bonferroni test and Chi-square test, while time comparisons by analysis of variance (ANOVA) and time-by-treatment interaction by repeated-measures ANOVA.ResultsFifty-seven subjects were assessed for CTT (placebo, n = 28; RMD, n = 29). In the RMD group, the total CTT, left SCTT and rectosigmoidal SCTT decreased significantly compared to baseline (p < 0.01 each; −13.3, −4.7, −8.7 h, respectively). Significant differences between groups were observed in total CTT and left SCTT. Significant time-by-treatment interaction was observed in the RMD group for stool volume (p = 0.014), increasing 56 % compared to baseline (p < 0.01), while remained unchanged in the placebo group. Stool consistency was improved only in the RMD group (p < 0.01). No adverse effects related to study products were observed.ConclusionsThe results show that RMD improved CTT, stool volume, stool consistency and some intestinal functions in a healthy population.

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Promotive effects of resistant maltodextrin on apparent absorption of calcium, magnesium, iron and zinc in rats

Cited by 43 publications

References 17 publications

Improvement Effect of Resistant Maltodextrin in Humans with Metabolic Syndrome by Continuous Administration

Improvement Effect of Resistant Maltodextrin in Humans with Metabolic Syndrome by Continuous Administration

Effects of Proton Pump Inhibitor Administration and Intake of a Combination of Yogurt and Galactooligosaccharides on Bone and Mineral Metabolism in Rats

Digestion-resistant maltodextrin effects on colonic transit time and stool weight: a randomized controlled clinical study

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